多发性硬化症患者DTI图像定量化分析

摘要 提出了一种联合体素和白质图谱的磁共振扩散张量成像(DTI)方法，明确了多发性硬化症(MS)患者脑白质中受损区域的位置和严重程度.通过计算受检者脑白质区域内各体素中水分子扩散的各向异性指数(FA)和平均扩散率(MD)，找出MS患者组和健康对照组(HC)之间FA和MD存在显著性差异的体素及分布情况.结果表明，与HC组相比，MS组FA值在胼胝体体部、压部和双侧放射冠上部等11个脑区有显著性降低;MD值在胼胝体体部、压部和右侧内囊后肢等22个脑区有显著性升高，为临床MS诊断和治疗提供了更有效的参考价值.
Abstract：A novel analysis method of magnetic resonance diffusion tensor imaging (DTI) was proposed， which combined the voxel-based analysis (VBA) with the white matter parcellation mapping (WMPM). Using this method， the locations and severities of white matter lesions of multiple sclerosis (MS) patients have been clarified. The voxels with significant difference of the fractional anisotropy (FA) and the mean diffusivity (MD) between MS patients and healthy controls (HC) are identified by VBA， and the distributions of these voxels in different white matter parcellations can be determined. It is shown that FA in MS group is significantly lower in 11 parcellations， mainly located at body and splenium of corpus callosum and both sides of corona radiate top. On the contrary， the higher MD is found in 22 parcellations including body and splenium of corpus callosum and posterior limb of right internal capsule. Therefore， the quantitative analysis of DTI through the proposed method provides effective references for the diagnosis and treatment of MS patients.