目的探讨鼻咽癌（NPC）放疗后误吸患者咽部生物力学特点。 方法回顾性收集本科室自2011年7月至2015年6月期间连续收治的NPC放疗后吞咽困难患者临床资料，其中有23例患者完成了视频吞咽造影检查（VFSS），并采用高分辨率固态测压系统对其咽腔压力和食道上括约肌（UES）松弛功能进行检测。根据VFSS有误吸将入选患者分为误吸组和误吸组，比较两组患者进食不同性状食物时其咽部生物力学差异。 结果进食浓流质或糊状食物发生误吸的患者其UES松弛残余压［进食浓流质时为（20.1±14.3）mmHg，进食糊状食物时为（18.0±14.3）mmHg］较误吸患者［进食浓流质时为（9.3±9.2）mmHg，进食糊状食物时为（7.2±8.9）mmHg］明显增高（P<0.05），而两组患者咽腔压力组间差异统计学意义（P>0.05）。 结论NPC放疗后误吸可能与UES松弛残余压增高有关。 Objective To explore the biomechanical characteristics of the pharynx in patients with aspiration after radiotherapy for nasopharyngeal carcinoma (NPC). MethodsClinical data on NPC patients with dysphagia admitted between July 2011 and June 2015 were retrospectively analyzed. Twenty-three patients were found who had received videofluoroscopic swallowing studies (VFSSs) and whose pharyngeal pressure and upper esophageal sphincter (UES) relaxing were tested using high-resolution solid-state manometry (HRM). The cases were divided into an aspiration group and a non-aspiration group according to the VFSS results. Differences in biomechanical parameters between the 2 groups when taking food of different viscosity were compared. Results Patients with aspiration had significantly higher UES residual pressure when taking thick liquids (20.1±14.3 mmHg) and paste (18.0±14.3 mmHg) than patients not aspirating (9.3±9.2 mmHg and 7.2±8.9 mmHg for thick liquid and paste respectively). But no significant difference in average pharyngeal pressure between the two groups was observed. Conclusion Aspiration after radiotherapy may be correlated with increased UES residual pressure
