基于Rs-fMRI的维、汉语脑卒中后失语症患者的脑功能研究
The brain functioning of aphasic Uyghur and Mandarin speakers after stroke

目的 利用静息态功能磁共振成像技术（Rs-fMRI）研究维族和汉族脑卒中失语症患者在静息态下脑自发活动的差异区，并初步探讨形成差异的原因。 方法 利用Rs-fMRI采集15例汉族脑卒中失语症患者（汉语组）和12例维族脑卒中失语症患者（维语组）静息态下的fMRI数据，对数据预处理后进行低频振幅（ALFF）指标的计算，最后对两组数据做组间统计学比较。 结果 静息状态下汉语患者的ALFF大于维语患者，汉语患者的右侧丘脑ALFF值增加。 结论 在静息态下汉族失语症患者的右侧丘脑处ALFF大于维族患者，可能是由于汉族患者左侧脑区脑卒中后，右侧丘脑部分参与了新的语言回路，对语言功能的损失起到了一定的代偿作用。
Objective To observe any differences in the spontaneous activity of brain areas between Mandarin-speaking and Uyghur-speaking aphasics at rest and explore the reasons. Methods Functional magnetic resonance imaging was used to scan the brains of 15 Mandarin-speaking and 12 Uyghur-speaking subjects. Statistical parametric maps of the active brain areas were prepared and low-frequency amplitude (ALEF) indexes were calculated. Results While at rest the ALEF indexes of the Mandarin-speakers were, on averge, larger than those of the Uyghur-speakers. The difference was primarily in the ALEF of the right thalamus. Conclusion At rest, the average ALEF of the right thalamus of aphasic Mandarin-speakers is larger than that of Uyghur-speakers. It might be that after a left-brain stroke the Mandarin-speakers form new language circuits with the help of the right thalamus which compensates for the loss of language function