高压氧治疗联合重复经颅磁刺激对脑梗死后认知功能障碍的疗效
The effect of hyperbaric oxygen therapy combined with repetitive transcranial magnetic stimulation on patients with cognitive dysfunction after cerebral infarction

目的 研究高压氧治疗联合重复经颅磁刺激（rTMS）对脑梗死后认知功能障碍的影响。 方法 将纳入的81例脑梗死后认知功能障碍患者经知情同意并签署知情同意书后按随机数字表法分为对照组、高压氧组和联合治疗组，每组27例，各组均接受基本药物和常规康复训练，高压氧组增加高压氧治疗，联合治疗组增加高压氧和rTMS治疗，分别于治疗前和治疗4周后(治疗后)，采用简易精神状态（MMSE）量表和蒙特利尔认知评估（MoCA）量表对各组患者进行认知功能评定，并进行统计学分析比较。 结果 治疗后，高压氧组和联合治疗组的MMSE评分分别为（22.65±5.79）和（24.84±5.88）分，均明显高于对照组［（18.84±4.11）分］，差异有统计学意义（P<0.05），且联合治疗组的MMSE评分较高压氧组有明显改善（P<0.05）；治疗后，高压氧组和联合治疗组的MoCA评分分别为（21.31±6.25）和（23.17±7.51）分，均明显高于对照组（18.31±4.81），且差异有统计学意义（P<0.05），而联合治疗组的MoCA评分较高压氧组亦有明显改善（P<0.05）。 结论 高压氧治疗联合rTMS能更有效地改善脑梗死后认知障碍患者的认知功能。
Objective To observe the effect of hyperbaric oxygen (HBO) therapy combined with repeated transcranial magnetic stimulation (rTMS) on patients with cognitive dysfunction after cerebral infarction. Methods A total of 81 patients with cognitive dysfunction after cerebral infarction were randomly divided into a control group, an HBO group and a combined treatment group, each of 27. In addition to basic medication and traditional rehabilitation therapy, the HBO group was also treated with hyperbaric oxygen, while the combined treatment group received both HBO and rTMS. The mini-mental state examination (MMSE) and the Montreal cognitive assessment (MoCA) were administered before and after the four weeks of treatment. Results The average MMSE scores of the HBO and combined treatment groups were both significantly higher than that of the control group, with the former significantly higher than the latter. Moreover, the average MoCA score of the HBO group was also significantly higher than that of the combined treatment group, and both were significantly higher than that of the control group. Conclusion Hyperbaric oxygen therapy can more effectively improve the cognitive function of patients with cognitive dysfunction after the cerebral infarction when it is combined with repeated transcranial magnetic stimulation