多巴胺系统基因对注意网络的调控作用

摘要： 多巴胺是脑内重要的神经递质之一，与注意活动紧密相关。本文选取作用于突触前膜、间隙和后膜的多巴胺系统基因——多巴胺转运蛋白基因、儿茶酚氧化甲基转移酶基因和多巴胺受体基因，整合影像遗传学研究，探讨多巴胺基因对注意网络的调控。元分析发现背侧和腹侧注意网络的主要脑区均有较大的基因调控效应，且腹侧网络的效应值显著大于背侧网络，表明多巴胺系统基因在全脑范围内调控注意网络，且对腹侧网络的调控作用更强于背侧网络。
Abstract: Dopamine (DA) is one of the major neurotransmitters in central nervous system and acts as a powerful modulator of different aspects of cognitive brain functions. Numerous studies have revealed the important role of DA on attention networks. However, current imaging genetics studies only focus on the effect of one single gene of the dopaminergic system on local brain regions (mostly prefrontal cortex) but ignore the whole brain analysis and comparison between different genes. To advance our understanding of DA on attention, we conducted a meta-analysis to examine modulatory effects of three typical dopamine genes on whole brain attention networks. A literature search was first performed on imaging genetics studies on modulation of DA in attention tasks through PubMed. Keywords included but not limited to functional magnetic resonance imaging (fMRI), and candidate dopaminergic system genes targeting the presynaptic, the postsynaptic neurons, or the synaptic cleft, such as the dopamine transporter gene (DAT), the catechol-O-methyltransferase gene (COMT) or the dopamine receptor gene (DRD). Reference lists were checked by hand and a total of forty-four papers were gathered and applied to our meta-analysis. We extracted the coordinates of peak voxels where genetic modulatory effect on attention was reported in the papers and then projected them onto a brain template in Caret to visualize the distribution of the modulatory effects of genes. Effect sizes were calculated using Cohen’s d to quantify the magnitude of activation difference between subjects with separate genotypes on each attention task. Random-effects model was chosen for the meta-analysis and effect sizes on effective modulation of dopaminergic system genes in different brain regions were calculated with Comprehensive Meta-Analysis program (CMA). To comparing difference across attention networks and dopaminergic genes, the Q-test of homogeneity was used to test for variations in effect size. Our results showed that the integrated effect sizes on effective modulation of dopaminergic system genes were all above .8 (Cohen’s d) in ventral attention network (VAN), including ventral prefrontal cortex (VLPFC), orbitofrontal gyrus (OFG), and superior temporal gyrus (STG), and also in dorsal attention network (DAN), consisting of dorsolateral prefrontal cortex (DLPFC), superior