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- 2018
藏汉双语者汉语阅读理解的静息态功能连接分析Keywords: Tibetan-Chinese bilinguals, Reading comprehension, Functional connectivity, Resting-state Abstract: 摘要: 研究结合静息态全脑功能连接密度和基于种子点的功能连接(FC)分析考察了藏汉双语者汉语(L2)阅读各子能力(细节捕捉和推理判断)的固有脑功能组织特点。结果发现左侧额下回—左侧颞上回和右侧舌回—右侧中央前回之间的FC值均与细节捕捉题得分和推理判断题得分呈显著正相关,但是左侧额下回—右侧顶下小叶之间的FC值只与推理判断题得分呈显著正相关。表明藏汉双语者汉语阅读各子能力之间既有重叠的又有不同的功能连接通路。Abstract: Resting-state functional connectivity (FC) studies have revealed that second language (L2) reading comprehension can be predicted by intrinsic functional organization (IFO) within language network. However, these studies select some specific seed regions in language network according to priori knowledge before FC analysis, which can result in some biased results and neglect of some important unpredictable findings. Additionally, most previous studies explore L2 reading comprehension largely taking reading as a global construct without considering the multidimensional structure of reading, thus little is known about the features of IFO related to subskills of reading ability in L2 learning. Therefore, the present study combines resting-state whole-brain functional connectivity density (FCD) with the FC analysis based on seed regions to investigate the characteristics of IFO associated with specific dimensions of L2 reading. Nineteen Tibetan-Chinese bilinguals were recruited in the present study and resting-state functional magnetic resonance imaging (fMRI) data were acquired in each participant. Then, the Chinese Character Reading Efficiency Test (CCRET) and the reading comprehension section of Hanyu Shuiping Kaoshi (HSK) were used to evaluate the global level and two dimensions (literal comprehension and inferential comprehension) of L2 reading respectively. Next, a novel voxel-level whole-brain FCD analysis was applied to find the key brain regions associated with L2 reading. Furthermore, the FC between key brain regions and each voxel was computed by conducting seed-based FC analysis, and the correlation between each FC and two dimensions of Chinese reading conprehension was also evaluated respectively. The results showed that literal comprehension scores in L2 reading were not only significantly correlated with inferential comprehension scores but also higher than inferential comprehension scores. FCD analysis found that the three key brain regions including the left inferior frontal gyrus, right lingual gyrus and right precuneus had significant correlations with CCRET scores. Further seed-based FC analysis revealed that both literal comprehension scores and inferential comprehension scores were positively correlated with the FC between the left inferior frontal gyrus and left superior temporal gyrus as well as between the right
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