数值模拟松质骨中流动电势分布

目的 对压力驱动下一种松质骨细观模型产生的流动电势进行数值模拟分析，了解流动电势在松质骨中的分布特点。方法 根据电场和流体的控制方程，利用有限单元法计算该松质骨模型在一定压力下产生的稳态流动电势。结果 松质骨模型中靠近固体表面的流动电势较大，约为43.4 μV；而远离固体表面的流动电势较小，约为19.7 μV。压力和Zeta电势对模型的流动电势影响比较大，并且呈线性增长的关系。离子数浓度较低时，离子数浓度对流动电势的影响较大；当离子数浓度较高时，离子数浓度对流动电势的影响很小。结论 研究结果为利用电流、电磁场刺激等方法防治和治疗临床骨折、老年性骨质疏松及其他骨科疾病提供相关的理论依据。
Objective To analyze the pressure-driven streaming potential in a cancellous bone meso-mechanical model with numerical simulation, so as to understand characteristics of streaming potential distributions in cancellous bone. Methods Based on the control equations of electric field and fluid, the finite element method was used to calculate the streaming potential in the cancellous bone model when subjected to pressure. Results The streaming potential near the solid surface of the model was relatively large (about 43.4 μV), while the streaming potential away from the solid surface was smaller (about 19.7 μV). Pressure and Zeta potential had a significant impact on the streaming potential of the model, presenting a linear relationship with the streaming potential. The streaming potential was greatly affected when the ion concentration was low, whereas the effect on the streaming potential was small when the ion concentration was high. Conclusions This research finding provides a theoretical reference for prevention and treatment by stimulation methods of electric current and electromagnetic fields in clinical fractures, senile osteoporosis and other bone diseases.