果蝇卵发育过程中卵上皮细胞的极化与排列行为

目的 研究果蝇卵室发育过程中卵上皮细胞的形态与排列行为。方法 建立模拟果蝇卵室发育过程的有限元模型，并开发描述材料生长的ABAQUS UMAT用户子程序。基于有限元方法模拟果蝇卵室第8阶段（S8）到第10阶段初始阶段（S10）的发育过程，通过分析上皮细胞层在卵剖面上主应力的方向和面内最大剪应力的分布，预测上皮细胞的极化和排列行为。结果 上皮细胞的排列方向与最大主应力的方向一致，而细胞的长细比与其最大剪应力成正比。结论 果蝇卵上皮细胞的极化和排列行为由组织内的应力控制。
Objective To study the polarization and arrangement of epithelial cells in the embryonic development of drosophila. Methods A finite element model was established to simulate the development of drosophila egg, and an ABAQUS UMAT user subroutine that describes the growth of materials was developed. The developmental process of the stages 8 (S8) to the initial state of the stage 10 (S10) was simulated， and the direction of principal stress and the distribution of the in-plane maximum shear stress (MSS) in the epithelial cell layer was analyzed, in order to predict the polarization and arrangement of the epithelial cells. Results The orientation of the epithelial cells was consistent with the direction of the maximum principal stress, and the aspect ratio of cells was proportional to the magnitude of the MSS. Conclusions The polarization and arrangement of the epithelial cells are controlled by the stress state in the tissues.