机械力刺激诱导机体组织炎症反应机制研究进展

机械力刺激能够诱发机体中包括牙周组织在内的多种组织发生无菌性炎症反应，并能促进免疫细胞以及一些非免疫细胞如牙周膜细胞发生焦亡（pyroptosis）。现有研究表明，Gasdermin-D（GSDMD）在炎症反应、细胞焦亡发生中具有重要作用，但GSDMD是否参与机械力刺激引发的炎症反应和细胞焦亡尚未可知。综述机械力刺激诱导机体组织炎症反应以及焦亡的信号通路研究进展。
Mechanical forces can induce aseptic inflammatory reactions in human tissues including periodontium, and promote the pyroptosis of immune cells and some non-immune cells such as periodontal ligament cells. Recent studies have revealed that Gasdermin-D (GSDMD) plays an indispensable role in inflammation as well as pyroptosis, while it remains unknown whether GSDMD participates in the mechanical force-induced inflammatory reaction and pyroptosis. The current progress in researches about the mechanical force-induced inflammatory reaction and the signaling pathways of pyroptosis in human tissues is reviewed.