基于应力状态的细胞分子水平骨重建力生物学模型

目的 建立基于应力状态的细胞分子水平骨重建力生物学模型。方法 从工程角度分析骨重建过程和力学激励，吸纳力学强度设计理论思想，选取相当应力作为力学激励，基于应力状态选取合适的力学激励计算公式，提出基于应力状态的细胞分子水平骨重建力生物学模型；应用模型进行口腔临床正畸牙槽骨的模拟预测。结果 张力区孔隙度降低，骨量增加；压力区孔隙度增加，骨量减少，与牙槽骨特性一致。结论 基于应力状态的细胞分子水平骨重建力生物学模型考虑应力状态对骨组织失效形式的影响，体现骨重建过程是力学激励下细胞水平的自优化强度设计，有助于在细胞分子水平探讨应力状态对骨重建的影响，是骨重建理论的补充和完善，可为口腔正畸的治疗提供理论指导。
Objective To develop a mechanobiological model of bone remodeling based on stress state at cellular and molecular level. Methods Through analysis of bone remodeling process and mechanical stimulus from an engineering perspective, as well as absorption from the idea of mechanical strength design theory, the equivalent stress as the mechanical stimulus and the appropriate calculation formula of mechanical stimulus based on stress state were selected to propose a mechanobiological model of bone remodeling based on stress state at the cellular and molecular level. The model was then used to simulate bone remodeling of alveolar bone in orthodontics. Results The reduction of the vascular porosity and increase of bone mass appeared in tensile stress area, while vascular porosity increased and bone mass reduced in compression stress area, which was consistent with the features of alveolar bone. Conclusions The mechanobiological model of bone remodeling based on stress state at cellular and molecular level considered the effect of stress state on failure forms of bone tissues, embodied bone remodeling as a cellular automaton optimization process under mechanical stimulus, which would contribute to investigating effects of stress state on bone remodeling at the cellular and molecular level. The study is a supplement and improvement of bone remodeling theory and will provide theoretical guidance for treatment of orthodontics.