动脉粥样硬化的疫苗防治策略
Vaccine strategies in prevention and treatment of atherosclerosis#br#

动脉粥样硬化是动脉壁的免疫炎症性疾病，包括针对多种内源性、外源性抗原的先天性和适应性免疫。同时，多项研究表明 免疫系统在动脉粥样硬化过程中发挥着双重作用。因此，采用免疫调节策略，激活针对相关抗原的免疫反应，有可能改变动脉粥样硬 化的自然进程。胆固醇酯转运蛋白（cholesterol ester transfer protein，CETP）在脂质代谢中发挥重要作用，是治疗动脉粥样硬化的重 要靶点。该文主要围绕 CETP 疫苗，就近年来抗动脉粥样硬化疫苗的研究进展作一综述。
：Atherosclerosis？is？an？immune-mediated？inflammatory？disease？of？the？arterial？wall,？with？both？the？innate？and？adaptive？immune？systems？responding？ to？many？endogenous？and？exogenous？antigens.？Both？proatherogenic？as？well？as？atheroprotective？roles？have？been？identified？for？the？immune？system？in？ atherosclerosis.？Hence,？it？is？conceivable？that？an？immuno-modulatory？strategy？via active immunization against many of these antigens could potentially alter the？natural？history？of？atherosclerosis.？Cholesterol？ester？transfer？protein？(CETP)？plays？an？important？role？in？lipid？metabolism,？suggesting？it？might？prevent？ atherosclerosis.？This？review？discusses？the？recent？advances？of？vaccine？targeting？the？development？of？atherosclerosis,？mainly？about？the？CETP？targeting？vaccines