序贯疗法降低部分脾栓塞术后不良反应的临床研究
Clinical analysis of sequential therapy with partial splenic embolization in decreasing postoperative adverse reactions

目的 探讨序贯疗法减少部分脾栓塞术（PSE）后不良反应的临床价值。方法 回顾98例肝硬化合并脾功能亢进患者病例资料，分为序贯PSE治疗组和PSE对照组（单次PSE），分析治疗前后血常规、肝功能、栓塞后综合征、术后并发症等相关情况。结果 2组白细胞和血小板治疗后2周、1个月分别与治疗前相比，均明显上升（P<0.01）；序贯组重度疼痛及高热发生率明显低于对照组（P<0.01），重度疼痛、发热持续时间及住院天数相对较短 （P<0.01），术后并发症发生率也明显低于对照组（P<0.01）。结论 序贯PSE能有效改善脾亢症状，减少、减轻PSE术后不良反应。
： Objective To explore the clinical value of sequential therapy with partial splenic embolization (PSE) in reducing postoperative adverse reactions. Methods Medical data of 98 patients with portal hypertension complicated with hypersplenism were retrospectively reviewed, which were divided into the sequential group (sequential PSE) and the control group (single PSE). The results of routine blood test, liver function, and incidence rate of post embolization syndrom,and postoperative complications were analyzed in patients of the two groups before and after the treatment. Results Compared with those before the treatment, white blood cells and platelets were significantly increased 2 weeks and 1 months after the treatment (P<0.01). Incidence rate of moderate and severe pain and high fever of the sequential group was obviously lower than that of the control group (P<0.01). The duration of moderate and severe pain and fever, and hospitalization day of the sequential group were relatively shorter (P<0.01). And the incidence of postoperative complications of the sequential group was obviously lower than that of the control group (P<0.01). Conclusion Sequential PSE can effectively improve the symptom of hypersplenism, and reduce the postoperative adverse reactions and complications of PSE