类风湿性关节炎患者滑膜组织中HIF-1α与MMPs相关性研究
Correlation between HIF-1α and MMPs in synovial tissues of patients with rheumatoid arthritis

目的 探讨类风湿性关节炎（RA）患者滑膜组织中缺氧诱导因子-1α（HIF-1α）的表达与基质金属蛋白酶家族成员（MMPs）表达的相关性。方法 利用real-time PCR方法检测RA和骨关节炎(OA)患者滑膜组织中HIF-1α和MMPs的表达并进行相关性分析。结果 RA滑膜组织中HIF-1α、MMP-1、MMP-3、MMP-9与MMP-13 mRNA表达量显著高于OA对照组，且RA滑膜组织中高表达的HIF-1α与MMP-9呈显著的正相关。结论 RA滑膜组织中高表达的HIF-1α可能参与调控MMP-9的表达，参与RA的病理变化进程。
： Objective To investigate the correlation between the expression of hypoxia-inducible factor-1α (HIF-1α) and the expression of matrix metalloproteinases (MMPs) in synovial tissues of patients with rheumatoid arthritis (RA). Methods The expressions of HIF-1α and MMPs in synovial tissues of patients with RA and osteoarthritis (OA) were detected by real-time PCR and the correlation analysis was conducted. Results The mRNA expressions of HIF-1α, MMP-1, MMP-3, MMP-9, and MMP-13 in synovial tissues of patients with RA were significantly higher than those of patients with OA. Highly expressed HIF-1α in synovial tissues of patients with RA significantly and positively correlated with MMP-9. Conclusion Highly expressed HIF-1α in synovial tissues of patients with RA may involve in the regulation of the expression of MMP-9 and the process of pathological change of RA