钙/钙调蛋白依赖性蛋白激酶Ⅱ在抑郁症中的作用机制研究
Advances of calcium/calmodulin-dependent protein kinase Ⅱin major depressive disorder

钙/钙调蛋白依赖性蛋白激酶Ⅱ（CaMKⅡ）在调节突触可塑性、谷氨酸受体和环腺苷磷酸反应元件结合蛋白（CREB）磷酸化等方面均起到关键作用，而这些生物学现象与抑郁症相关。文章就CaMKⅡ在抑郁症中可能的相关机制进行综述。
： Calcium/calmodulin-dependent protein kinase Ⅱ (CaMKⅡ) plays a crucial role in regulation of synaptic plasticity, glutamate receptors, and phosphorylation of cyclic adenosine phosphate response element binding protein (CREB), which are relevant to the major depressive disorder. This paper reviews possible mechanisms of CaMKⅡ in the process of major depressive disorder