金黄色葡萄球菌ESAT-6分泌系统研究进展
Research advances in ESAT-6 secretion system in Staphylococcus aureus

金黄色葡萄球菌是临床重要的致病菌，引起的感染可以累及全身各脏器，严重威胁人类健康。ESAT-6分泌系统广泛存在于革兰阳性菌。在金黄色葡萄球菌中，经典的ESAT-6通路由esxA、esxB及其他9个分子组成的基因簇构成，该系统分泌的ESAT-6/WXG100家族蛋白对金黄色葡萄球菌的毒力和免疫防御功能起到重要作用。该文就金黄色葡萄球菌ESAT-6分泌系统的研究进展进行综述。
： Staphylococcus aureus is an important opportunistic pathogen that causes a variety of infections, which can involve all organs in the body and seriously threat people’s health. The ESAT-6 secretion system widely exists in gram-positive bacteria. Typical ESAT-6 pathway is composed of a gene cluster consisting of esxA, esxB, and nine other molecules in Staphylococcus aureus. ESAT-6/WXG100 protein family secreted by this system plays a critical role in virulence and protective immunity of Staphylococcus aureus. This article reviews research advances in ESAT-6 secretion system in Staphylococcus aureus