与TGF-β/Smads通路相关的病理性瘢痕治疗策略研究进展
Research progresses of TGF-β/Smads signaling pathway-related therapeutic strategies for pathological scar

病理性瘢痕是常见而多发的病症，对患者的身心健康造成严重影响。转化生长因子β（TGF-β）是目前研究已知的最强促纤维化因子，TGF-β/Smads信号通路与瘢痕化的关系密切，其中突出表现为抑制蛋白酶和基质酶活性的同时促进胶原等细胞外基质的形成，进而促进细胞外基质沉积。该文就目前针对TGF-β/Smads信号通路防治病理性瘢痕的研究作一综述，探讨更佳的治疗方式。
： Pathological scar is a common and frequent disorder that seriously affects physical and psychological health of patients. Studies found that transforming growth factor β (TGF-β) is the most potent profibrosis factor known so far. TGF-β/Smads signal pathway is closely associated with scarring and is highlighted with inhibiting the activity of protease and matrix enzyme, as well as promoting the formation of extracellular matrixes such as collagen, and further promotes the deposition of extracellular matrixes. This paper reviews studies on prevention and treatment of pathological scar via TGF-β/Smads signal pathway and investigates better therapeutic methods