CD147基因多态性与颈动脉斑块易损性的相关性
Correlation between the polymorphism of CD147 gene and instability of carotid plaque

目的·探讨CD147基因rs8637位点多态性与颈动脉斑块易损性的相关性。方法·将442例脑梗死住院患者根据颈动脉超声分为易损斑块组（320例）和稳定斑块组（122例），采用聚合酶链反应-高温连接酶检测反应（PCR-LDR）技术对CD147基因rs8637位点多态性进行分析。结果·易损斑块组的rs8637位点AG+GG基因型频率和G等位基因频率分别为94.38%和73.42%，和稳定斑块组相比差异有统计学意义（P均<0.05），2组间年龄、血糖、血压、总胆固醇（TC）、三酰甘油（TAG）、低密度脂蛋白胆固醇（LDL-C）和高密度脂蛋白胆固醇（HDL-C）水平的差异无统计学意义。结论·CD147基因rs8367位点多态性可能与中国人群颈动脉易损斑块发生的倾向性有关，G等位基因可能是颈动脉易损斑块的遗传易患基因。
： Objective·To investigate the correlation between the polymorphism of locus rs8637 in CD147 gene and instability of carotid plaque. Methods·Four hundred and forty-two inpatients with cerebral infraction were assigned to the vulnerable plaque group (n=320) and the stable plaque group (n=122) according to the results of carotid B-mode ultrasonography. The polymorphism of locus rs8637 in CD147 gene was analyzed by polymerase chain reaction-the ligase detection reaction (PCR-LDR). Results·The frequencies of AG+GG genotype and G allele at locus rs8637 in the vulnerable plaque group were 94.38% and 73.42%. The differences between two groups were statistically significant (P<0.05). The differences in age, blood glucose, blood pressure, TC, TAG, LDL-C, and HDL-C between the two groups were not statistically significant. Conclusion·The polymorphism of locus rs8637 in CD147 gene may be associated with carotid vulnerable plaque and the G allele may be a genetic susceptible gene for carotid vulnerable plaque