小胶质细胞在自发性蛛网膜下腔出血中的激活机制及针对其的 治疗进展
Activation mechanism and therapeutic use of microglia in subarachnoid hemorrhage#br#

蛛网膜下腔出血（SAH）发生后，小胶质细胞活化并参与早期脑损伤和迟发性脑缺血的病理生理过程，决定SAH 患者的转 归。众多研究表明，小胶质细胞在 SAH 中有不同的分型和激活通路，功能也不尽一致。因此，干预 SAH 后小胶质细胞的激活过程或 减少释放细胞毒性代谢物，对于改善 SAH 患者预后具有重要意义。
：Microglia are activated and involve in the pathological and physiological processes of early brain injury and delayed cerebral ischemia after subarachnoid hemorrhage, thus impact the outcome of patients. Numerous studies have shown that microglia have different typings, signaling pathways, and functions. Interference with microglial activation or reduction of cytotoxic metabolites is important for improving the prognosis of SAH patients