Pi3k/Akt信号通路与非典型抗精神病药物作用机制的研究进展
Research progress of role of Pi3k/Akt pathway in mechanism of atypical antipsychotic drugs

Pi3k/Akt信号通路在精神分裂症的发病机制中发挥着重要作用，而非典型抗精神病药物对 Pi3k/Akt信号通路具有一定的修饰作用，且该作用已受到研究人员的广泛关注。该文从代谢综合征、免疫功能变化、认知损害、神经保护作用 4个方面，将 Pi3k/Akt信号通路与非典型抗精神病药物作用机制之间关系的研究进展进行综述。
：The alterations of Pi3k/Akt pathway may be critical in the pathogenesis of schizophrenia. Furthermore, atypical antipsychotic drugs can modify Pi3k/Akt pathway, which have been received wide attention. This review mainly focused on four aspects, i.e. metabolic syndrome, changes in immune function, cognitive impairment and neuroprotective effect, and summarized the research progress of role of Pi3k/Akt pathway in the mechanism of atypical antipsychotic drugs