病毒宏基因组学方法鉴定出小熊猫粪便中一株新型指环状病毒
Viral metagenomics revealed a novel species of anellovirus in feces of red panda

研究从2份小熊猫粪便样品中检测到了一种新型的指环状病毒,命名为AV-Chengdu1 (GenBank KX611132)。全基因组测序结果表明,其基因组全长约2 900 nt,GC含量为49.8%;基因组结构分析表明其含3个开放阅读框(ORF1:1 743 nt,ORF2:393 nt,ORF3:399 nt),其中ORF1编码产物的氨基酸序列与一株来自松貂的指环状病毒的氨基酸序列(JN704611)同源性为56.4%。系统进化分析表明其与来自松貂的指环状病毒(JN704611)紧密聚类。
A novel anellovirus strain named AV-Chengdu1 was identified in feces from two red pandas.Sequence analysis showed that the 2 900 nt genome with a G+C content of 49.8% (GenBank KX611132) contained three open reading frames (ORFs) encoding peptides of 581,1 and 133 aa in length.The homology between the largest peptide and the counterpart of pine marten torque teno virus (TTV) (JN704611) was 56.4%.Phylogenetic analysis indicated that AV-Chengdu1 was a close relative of pine marten TTV.