测量生物组织等效杨氏模量的毫米压痕仪
Measurement of the reduced elastic modulus of biological soft tissues with mm-indentation elastometer

生物组织的弹性是诊断其是否发生病变的重要依据，杨氏模量是反映组织弹性的重要参数。以Labview为软件平台结合数据采集和运动控制等硬件设备，研制了一套测量弹性模量的毫米压痕弹性仪。以市购冷鲜牛肉、猪肉、猪肝和猪肾为试样，测量了球形压头向试样施加的负载力和对应的试样压痕深度，在对测量数据进行校准的基础上，利用基于赫兹接触力学模型的压头半径R、作用力F、压痕深度δ与试样等效杨氏模量E*间的解析关系，得到各试样的等效杨氏模量。实验结果表明，测得的组织试样等效杨氏模量数值与文献基本相符，所设计的毫米级压痕法测试装置可用于生物组织等效杨氏模量的检测。
The elasticity of biological tissue is the major basis to determine if any disease occurs within the tissue. Young's modulus is a key parameter that represents the elasticity of the tissue. This paper mainly deals with the set-up of an mm-indention elastometer using Labview software platform and some hardware like data acquisition card and motion control card etc. And by using the mm-indention elastometer, the experiments are conducted for purchased cold-fresh beef, pork, pig liver & kidney samples from the market. During the experiments the data of load force and indentation depth on tissue samples acted by a spherical indenter are directly obtained by the system itself. Then the reduced elastic modulus of tested samples can be deducted according to the analytic relationship between indenter radius R, load force F, indentation depth and sample's equivalent Young's modulus E* after the measured data are calibrated. The experimental results are coincident with that in reported papers. It shows that that the designed indentation device in millimeter scale can be adapted to measure the equivalent Young's modulus of biological tissue.