血清维生素D与2型糖尿病视网膜病变关系的研究

Objective To investigate the relationship between diabetic retinopathy(DR) and serum vitamin D in patients with type 2 diabetes mellitus (T2DM).Methods A total of 310 patients with T2DM both managed in the bio-bank and the diabetes management system of Center for Disease Control and Prevention of Minhang District during Feb.,2012 to Dec.,2014 were selected.Then 205 patients were divided into non diabetic retinopathy group (NDR) and 105 patients into DR group according to the fundus examinations.The patients’ demographical information,medical history and laboratory essays were collected,serum 25(OH)D levels were detected.Results Single factor analysis indicated that,compared with NDR group,25(OH)D level of DR group decreased(t=3.465,P<0.001),prevalence of 25(OH)D deficiency rose (χ2=5.313,P=0.021),however,prevalence of 25(OH)D insufficiency showed no statistical significance (χ2=0.990,P=0.320).Binary Logistic regression analyses showed the inverse correlation between 25(OH)D level and DR (OR=0.954,95%