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- 2018
中性粒细胞与淋巴细胞比值对急性脑梗死溶栓患者预后的预测
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Abstract:
摘要 目的:探讨中性粒细胞与淋巴细胞比值(neutrophil to lymphocyte ratio,NLR)对急性脑梗死(acute cerebral infarction,ACI)溶栓患者预后的预测价值.方法:回顾性连续纳入的急性脑梗死溶栓患者123例,其中男80例,女43例.根据改良Rankin量表评分标准,分为预后良好组(71例)及预后不良组(52例).比较2组患者的临床资料并进行多元Logistics回归分析,采用受试者工作特征(ROC)曲线评价入院时NLR水平,对急性脑梗死溶栓患者进行预后的评估.结果:2组在年龄、高血压、房颤、入院时美国国立卫生研究院卒中量表(NIHSS)评分、溶栓后1hNIHSS评分、血糖、白细胞计数、中性粒细胞计数、淋巴细胞计数及NLR水平方面比较,差异有统计学意义(P<0.05).多因素Logistics回归分析显示,中性粒细胞计数、NLR、白细胞计数、溶栓后1hNIHSS评分是ACI溶栓患者预后的独立危险因素,预测曲线下面积分别是0.632、0.701、0.685、0.867.入院时NLR预测急性脑梗死溶栓患者预后的最佳界值为3.375,其敏感度和特异度分别是59.6%和81.7%.结论:入院时NLR对急性脑梗死溶栓患者预后有一定的预测价值.
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