Subjective Lowering of Preprandial Blood Glucose and Cancer Prevention by Planning and Recognizing Initial Hunger

We recently described the training of the passage from scheduled to demanded meals in infants and adults. Subjects reduced energy intake by subjectively abolishing conditioned meals and by allowing intake only after demand by the infant or after hunger perception by the adult (Initial Hunger Meal Pattern; IHMP). Conditioned meals were those scheduled and/or presented to the infant as well to the adult by sight, smell, mentioning, gesturing or simply at a fixed mealtime. During IHMP instead, meals were suspended until the first infant’s demand or until an adult’s self-noticing arousal of hunger. IHMP was checked by measuring blood glucose before three meals per day (MBG) and was associated with significant decreases in diary-reported energy-intake, MBG, glycated hemoglobin, body weight, insulin AUC in glucose tolerance tests and in days with diarrhea as compared to randomized control subjects who maintained conditioned meals. Although generalized, conditioned eating is a modern aberration that is associated with development of insulin resistance and overall inflammation. These associations are well demonstrated independently from the implicated mechanism. A state of Overall Subclinical Inflammation greatly increases cell and DNA replications and replication errors. After decades of DNA errors, oncogenic cells arise and cumulate. A prevention of malignancies is possible by interrupting the development of conditioned eating, insulin resistance and associated overall inflammation.