We report a case of pure struma ovarii tumor diagnosed by cytology during laparoscopic surgery. The patient was a 34-year-old Japanese woman, gravida 1, para 1, who had the left adnexal mass, and was pre-operatively diagnosed as left ovarian endometriotic cyst or mature cystic teratoma by magnetic resonance imaging findings. She underwent laparoscopy, and the content of the left ovarian cystic tumor was found to be yellow gelatinous material, suggesting mature cystic teratoma. The imprint cytology of the tumor showed benign glandular pattern, suggesting struma ovarii. Histopathological findings led us to the diagnosis of pure struma ovarii with positive reactions for thyroglobulin and thyroid transcription factor-1. No metastases or disseminated lesions were detected. The patient has no recurrent signs 7 months after the operation.
References
[1]
Roth, L.M. and Talerman, A. (2007) The Enigma of Struma Ovarii. Pathology, 39, 139-146. https://doi.org/10.1080/00313020601123979
[2]
Yoo, S.C., Chang, K.H., Lyu, M.O., Chang, S.J., Ryu, H.S. and Kim, H.S. (2008) Clinical Characteristics of Struma Ovarii. Journal of Gynecologic Oncology, 19, 135-138. https://doi.org/10.3802/jgo.2008.19.2.135
[3]
Prat, J., Cao, D., Carinelli, S.G., Nogales, F.F., Vang, R. and Zaloudek, C.J. (2014) Monodermal Tratomas and Somatic-Type Tumours Arising from a Dermoid Cyst. In: Kurman, R.J., Carcangiu M.L., Herrington, C.S., Young, R.H., Eds., WHO Classification of Tumours of Female Reproductive Organs, International Agency for Research on Cancer (IARC), WHO Press, Lyon, 63.
[4]
Mancuso, A., Triolo, O., Leonardi, I. and De Vivo, A. (2001) Struma Ovarii: A Rare Benign Pathology Which May Erroneously Suggest Malignancy. Acta Obstetricia et Gynecologica Scandinavica, 80, 1075-1076.
https://doi.org/10.1034/j.1600-0412.2001.801121.x
[5]
Wee, J.Y., Li, X., Chern, B.S. and Chua, I.S. (2015) Struma Ovarii: Management and Follow-Up of a Rare Ovarian Tumour. Singapore Medical Journal, 56, 35-39.
https://doi.org/10.11622/smedj.2015007
[6]
Boutross-Tadross, O., Saleh, R. and Asa, S.L. (2007) Follicular Variant Papillary Thyroid Carcinoma Arising in Struma Ovarii. Endocrine Pathology, 18, 182-186.
https://doi.org/10.1007/s12022-007-0022-8
[7]
Schmidt, J., Derr, V., Heinrich, M.C., Crum, C.P., Fletcher, J.A., Corless, C.L. and Nose, V. (2007) BRAF in Papillary Thyroid Carcinoma of Ovary (Struma Ovarii). The American Journal of Surgical Pathology, 31, 1337-1343.
https://doi.org/10.1097/PAS.0b013e31802f5404
[8]
Devaney, K., Snyder, R., Norris, H.J. and Tavassoli, F.A. (1993) Proliferative and Histologically Malignant Struma Ovarii: A Clinicopathologic Study of 54 Cases. International Journal of Gynecological Pathology, 12, 333-343.
https://doi.org/10.1097/00004347-199310000-00008
[9]
Ayhan, A., Yanik, F., Tuncer, R., Tuncer, Z.S. and Ruacan, S. (1993) Struma Ovarii. International Journal of Gynecology & Obstetrics, 42, 143-146.
https://doi.org/10.1016/0020-7292(93)90628-A
[10]
Fujiwara, S., Tsuyoshi, H., Nishimura, T., Takahashi, N. and Yoshida, Y. (2018) Precise Preoperative Diagnosis of Struma Ovarii with Pseudo-Meigs’ Syndrome Mimicking Ovarian Cancer with the Combination of (131)I Scintigraphy and (18)F-FDG PET: Case Report and Review of the Literature. Journal of Ovarian Research, 11, 11. https://doi.org/10.1186/s13048-018-0383-2
[11]
Ikeuchi, T., Koyama, T., Tamai, K., Fujimoto, K., Mikami, Y., Konishi, I. and Togashi, K. (2012) CT and MR Features of Struma Ovarii. Abdominal Radiology, 37, 904-910. https://doi.org/10.1007/s00261-011-9817-7
[12]
Matsuki, M., Kaji, Y., Matsuo, M. and Kobashi, Y. (2000) Struma Ovarii: MRI Findings. The British Journal of Radiology, 73, 87-90.
https://doi.org/10.1259/bjr.73.865.10721328
[13]
Daneshbod, Y., Atefi, S., Daneshbod, K. and Ganjei-Azar, P. (2007) Cytologic Findings in Struma Ovarii. Diagnostic Cytopathology, 35, 612-614.
https://doi.org/10.1002/dc.20696
[14]
Daneshbod, Y., Daneshbod, K., Rasekhi, A.R., Mosayebi, Z., Negahban, S., Hodjati, S.R., Bedayat, G.R. and Ganjei-Azar, P. (2008) Cytologic Differentiation of Struma Ovarii from Other Ovarian Neoplasms. Acta Cytologica, 52, 72-76.
https://doi.org/10.1159/000325437
[15]
Wei, S., Baloch, Z.W. and Li Volsi, V.A. (2015) Pathology of Struma Ovarii: A Report of 96 Cases. Endocrine Pathology, 26, 342-348.
https://doi.org/10.1007/s12022-015-9396-1
[16]
Ezon, I., Zilbert, N., Pinkney, L., Wei, J.J., Malik, R. and Nadler, E.P. (2007) A Large Struma Ovarii Tumor Removed via Laparoscopy in a 16-Year-Old Adolescent. Journal of Pediatric Surgery, 42, E19-E22.
https://doi.org/10.1016/j.jpedsurg.2007.05.003
[17]
Nurliza Binti Md, N., Kusumoto, T., Inoue, S., Nakamura, K., Seki, N., Hongo, A., Kodama, J. and Hiramatsu, Y. (2013) Three Cases of Struma Ovarii Underwent Laparoscopic Surgery with Definite Preoperative Diagnosis. Acta Medica Okayama, 67, 191-195.
