Background: The number of reported MDR-TB cases has been increasing in recent years. Objectives: To describe the epidemiological profile of MDR-TB cases in Bangladesh. Design: This was a descriptive cross-sectional study. Settings: The study was conducted among the multi drug resistant tuberculosis patient admitted in the National Institute of Diseases of the Chest and Hospital (NIDCH) Dhaka, Bangladesh. Samples: 148 confirmed cases of MDR-TB. Materials and Methods: Hospital admitted MRD-TB cases were randomly chosen from the above mentioned hospital. Semi-structured and pretested questionnaire were introduced by researcher. Clinical and treatment data i.e. duration of TB drug intake, report of sputum, X-ray and blood test etc. were extracted from the hospital record. Results: Study found, majority of the participants (56.1%) were in the age group of 16 - 30 years. 64.2% of the study subjects were married. Majority of the participants education were whether under primary or primary level. 24.3% participant’s family member and 14.5% of neighbor were having TB. Most common comorbidity were diabetes, pulmonary infection, hearing loss, psychiatric symptoms, chest pain, joint pain etc. 63.5% respondent had high degree of AFB for sputum positivity and more than 98% had positive finding in X-ray chest. On an average ESR was low and also few cases of extremely low ESR were found. 71.6% were under twenty four months regimen. Conclusion: We can conclude that, many possible factors for MDR-TB. There is an urgent need for further study to confirm the exact factors in Bangladesh and address those immediately.
References
[1]
Eker, B., Ortmann, J., Migliori, G.B., Sotgiu, G., Muettcrlcin, R., Centis, R., et al. (2008) Multidrug- and Extensively Drug-Resistant Tuberculosis, Germany. Emerging Infectious Diseases, 14, 1700-1706. https://doi.org/10.3201/eid1411.080729
[2]
Zumla, A., George, A., Sharma, V., Herbert, R.H.N., of Ilton, B.M., Oxley, A., et al. (2015) The WHO 2014 Global Tuberculosis Report—Further to Go. The Lancet Global Health, 3, e10-e2. https://doi.org/10.1016/S2214-109X(14)70361-4
[3]
World Health Organization (2014) Global Tuberculosis Report 2014. Geneva.
[4]
World Health Organization. WHO Report 2011. Global Tuberculosis Control.
http://apps.who.int/iris/bitstream/10665/44728/1/9789241564380_eng.pdf
[5]
Fahmidul Haque, A.K.M., Khan, A., Lutfunnahar, B., Mukti, I.J., Islam, T., Chakma, S., et al. (2014) Assessment of Bangladeshi Mothers’ Knowledge and Awareness on Childhood Tuberculosis: A Cross Sectional Study. Science Journal of Public Health, 2, 309-315.
[6]
Bangladesh, TB Care-II, Funded by USAID, 2014.
http://tbcare2.org/cp-bangladesh
[7]
NTP. National Tuberculosis Control in Bangladesh. Annual Report 2007. National Tuberculosis Control Programme, DGHS, MOH&FW. Dhaka, 2008.
[8]
National TB Control Programme DGoHS, Bangladesh. Tuberculosis Control in Bangladesh. Annual Report. Dhaka, 2014.
[9]
Kamal, S.M., Hossain, A., Sultana, S., et al. (2015) Anti-Tuberculosis Drug Resistance in Bangladesh: Reflections from the First Nationwide Survey. International Journal of Tuberculosis and Lung Disease, 19, 151-156.
https://doi.org/10.5588/ijtld.14.0200
[10]
Zumla, A., Abubakar, I., Raviglione, M., Hoelscher, M., Ditiu, L., McHugh, T.D., et al. (2012) Drug-Resistant-Tuberculosis—Current Dilemmas, Unasnswered Questions, Challenges and Priority Needs. The Journal of Infectious Diseases, 205, S228-S240. https://doi.org/10.1093/infdis/jir858
[11]
World Health Organization (2011) Towards the Universal Access to Diagnosis and Treatment of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis by 2015, WHO Progress Report. WHO, Geneva.
Andrews, J.R., Shah, N.S., Weissman, D., Moll, A.P., Friedland, G. and Gandhi, N.R. (2010) Predictors of Multidrug and Extensively Drug-Resistant Tuberculosis in a High HIV Prevalence Community. PLoS One, 5, 1-6.
https://doi.org/10.1371/journal.pone.0015735
[14]
El Mahalli, A. and Al-Qahtani, M.F. (2015) Predictors of Drug Resistance in Tuberculosis Patients in the Eastern Province, Saudi Arabia. Journal of the Egyptian Public Health Association, 90, 24-28.
https://doi.org/10.1097/01.EPX.0000461677.83722.78
[15]
Tony, S.J., Elspeth, M.S. and Peter, D. (2010) Tuberculosis, Bronchiectasis and Chronic Airflow Obstruction. Respirology, 15, 623-628.
https://doi.org/10.1111/j.1440-1843.2010.01749.x
Worku, Y., Getinet, T., Mohammed, S. and Yang, Z. (2018) Drug-Resistant Tuberculosis in Ethiopia: Characteristics of Cases in a Referral Hospital and the Implications. International Journal of Mycobacteriology, 7, 167-172.
https://doi.org/10.4103/ijmy.ijmy_48_18
[18]
Ali, M.K., Karanja, S. and Karama, M. (2017) Factors Associated with Tuberculosis Treatment Outcomes among Tuberculosis Patients Attending Tuberculosis Treatment Centres in 2016-2017 in Mogadishu, Somalia. Pan African Medical Journal, 28, 197.
[19]
Di Gennaro, F., Pizzol, D., Cebola, B., Stubbs, B., Monno, L., Saracino, A., et al. (2017) Social Determinants of Therapy Failure and Multi Drug Resistance among People with Tuberculosis: A Review. Tuberculosis, 103, 44-51.
https://doi.org/10.1016/j.tube.2017.01.002
[20]
Zhao, Y., Feng, Q., Tang, K., Zhang, C., Sun, H. and Luo, T. (2012) The Population Structure of Drug-Resistant Mycobacterium Tuberculosis Clinical Isolates from Sichuan in China. Infection, Genetics and Evolution, 12, 718-724.
https://doi.org/10.1016/j.meegid.2011.09.022
[21]
Mohammadzadeh, Kh.A., Ghayoomi, A. and Maghsoudloo, D. (2016) Evaluation of Factors Associated with Failure of Tuberculosis Treatment under DOTS in Northern Islamic Republic of Iran. Eastern Mediterranean Health Journal, 22, 87-94.
https://doi.org/10.26719/2016.22.2.87
[22]
Chen, J., Cao, W., Chen, R., Ren, Y. and Li, T. (2016) Prevalence and Determinants of HIV in Tuberculosis Patients in Wuxi City, Jiangsu Province, China: A Cross-Sectional Study. International Journal of STD & AIDS, 27, 1204-1212.
https://doi.org/10.1177/0956462415612618
[23]
Stosic, M., Vukovic, D., Babic, D., Antonijevic, G., Foley, K.L., Vujcic, I., et al. (2018) Risk Factors for Multidrug-Resistant Tuberculosis among Tuberculosis Patients in Serbia: A Case-Control Study. BMC Public Health, 18, 1114.
https://doi.org/10.1186/s12889-018-6021-5
[24]
Venkatesh, U., Srivastava, D.K., Srivastava, A.K. and Tiwari, H.C. (2018) Epidemiological Profile of Multidrug-Resistant Tuberculosis Patients in Gorakhpur Division, Uttar Pradesh, India. Journal of Family Medicine and Primary Care, 7, 589-595. https://doi.org/10.4103/jfmpc.jfmpc_99_17