全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Patient Preferences in the Treatment of Vaginal Candidiasis

DOI: 10.4236/ojog.2018.812116, PP. 1147-1155

Keywords: Candidiasis, Miconazole, Patient Preference, Vulvovaginal Yeast Infections

Full-Text   Cite this paper   Add to My Lib

Abstract:

Vulvovaginal candidiasis (VVC) is one of the most frequent problems facing women and their healthcare professionals (HCP). It is difficult for providers to understand the prevalence of VVC because effective over the counter treatments (OTC), are available. It is expected that there are a great many more episodes of VVC in our patient population, as the frequency of self-treatment, success and satisfaction for those that use OTC products prior to seeing a women’s health care provider is unknown. In this study; healthcare providers were given OTC miconazole/tioconazole units for free distribution to patients for whom they diagnosed VVC by exam in their offices. Surveys for both HCP and patients were also distributed to determine the initial or recurrent nature of their symptoms and their satisfaction with their treatments. 1265 OBGYNs and 1821 NP/CNM/PAs reported on over 19,000 patients receiving a single complete treatment. Among HCPs, treatment efficacy was the primary reason for recommending miconazole/tioconazole. However, rapid onset of symptom relief, safety vs. fluconazole, patient preference for the less messy ovule, avoidance with drugs metabolized by the liver, and resistance to, or failure on, fluconazole were additional reasons noted for topical preference. Overall, patient satisfaction (n =

References

[1]  Mintz, J.D. and Martens, M.G. (2013) Prevalence of Non-Albicans Candida Infections in Women with Recurrent Vulvovaginal Symptomatology. Advances in Infectious Diseases, 3, 238-242.
https://doi.org/10.4236/aid.2013.34035
[2]  Centers for Disease Control and Prevention, Sexually Transmitted Diseases Treatment Guidelines (2015)
http://www.cdc.gov/std/tg2015/tg-2015-print.pdf
[3]  Sobel, J.D., Wiesenfeld, H.C., Martens, M.G., et al. (2004) Maintenance Fluconazole Therapy for Recurrent Vulvovaginal Candidiasis. The New England Journal of Medicine, 351, 876-883.
https://doi.org/10.1056/NEJMoa033114
[4]  van Heusden, A.M., Merkus, H.M., Corbeij, H.S., et al. (1990) Single-Dose Oral Fluconazole versus Single-Dose Topical Miconazole for the Treatment of Acute Vulvovaginal Candidosis. Acta Obstetricia et Gynecologica Scandinavica, 69, 417-422.
https://doi.org/10.3109/00016349009013305
[5]  Bruggemann, R.J., Alffenaar, J.W., Blijlevens, N.M., et al. (2009) Clinical Relevance of the Pharmacokinetic Interactions of Azole Antifungal Drugs with Other Coadministered Agents. Clinical Infectious Diseases, 49, 1441-1458.
https://doi.org/10.1086/598327
[6]  Sinofsky, F.E. and Pasquale, S.A. (1998) The Effect of Fluconazole on Circulating Ethinyl Estradiol Levels in Women Taking Oral Contraceptives. American Journal of Obstetrics & Gynecology, 178, 300-304.
https://doi.org/10.1016/S0002-9378(98)80016-1
[7]  Willams, N.S., Phillips, N. and Bachmann, G. (2015) Oral Compared with Local Antifungal Treatment of Yeast Infection: Comparison of Time to Symptomatic Relief. Obstetrics & Gynecology, 125, 11S.
https://doi.org/10.1097/01.AOG.0000463549.01588.2b
[8]  Marchaim, D., Lemanek, L., Bheemreddy, S., Kaye, K.S. and Sobel, J.D. (2012) Fluconazole-Resistent Candida albicans Vulvovaginitis. Obstetrics and Gynecology, 120, 1407-1414.
https://doi.org/10.1097/AOG.0b013e31827307b2
[9]  Shabid, Z. and Sobel, J.D. (2009) Reduced Fluconazole Susceptibility of Candida albicans Isolates in Women with Recurrent Vulvovaginal Candidiasis: Effects of Long-Term Fluconazole Therapy. Diagnostic Microbiology and Infectious Disease, 64, 354-356.
https://doi.org/10.1016/j.diagmicrobio.2009.03.021
[10]  Vazquez, J.A., Peng, G., Sobel, J.D., et al. (2001) Evolution of Antifungal Susceptibility among Candida Species Isolates Recovered from Human Immunodeficiency Virus-Infected Women Receiving Fluconazole Prophylaxis. Clinical Infectious Diseases, 33, 1069-1075.
https://doi.org/10.1086/322641

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133