Background: Treatment
of Cervical cancer includes a combination of external beam radiotherapy (EBRT) with intracavitary brachytherapy(ICBT).
ICBT helps to boost radiation dose to primary disease. Organs like rectum,bladder,sigmoid
and small bowel lieclose to the cervix region and these organs receive dose from EBRT as
well as ICBT and we want to know the dose to these organ
at risk (OAR).Materials & Methods: Dosimetric
details of 174 ICBT applications done in 58 patients were retrospectively
analysed. All patients received EBRT dose of 50.4 Gy in 28 fractions. All
patients had ICBT, three sessions with 7 Gy prescribed to point A.
References
[1]
GLOBOCAN Cancer Fact Sheets: Cervical Cancer (2018). http://globocan.iarc.fr/old/FactSheets/cancers/cervix-new.asp
[2]
Green, J., Kirwan, J., Tierney, J., Symonds, P., et al. (2001) Survival and Recurrence after Concomitant Chemotherapy and Radiotherapy for Cancer of the Uterine Cervix: A Systematic Review and Meta-Analysis. Elsevier. https://www.sciencedirect.com/science/article/pii/S0140673601059657
[3]
Recently Updated NCCN Clinical Practice Guidelines in OncologyTM (2018). https://www.nccn.org/professionals/physician_gls/recently_updated.aspx
[4]
Logsdon, M.D. and Eifel, P.J. (1999) FIGO IIIB Squamous Cell Carcinoma of the Cervix: An Analysis of Prognostic Factors Emphasizing the Balance between External Beam and Intracavitary Radiation Therapy. International Journal of Radiation Oncology*Biology*Physics, 43, 763-775. https://www.sciencedirect.com/science/article/pii/S0360301698004829 https://doi.org/10.1016/S0360-3016(98)00482-9
[5]
Montana, G.S., Martz, K.L. and Hanks, G.E. (1991) Patterns and Sites of Failure In Cervix Cancer Treated in the U.S.A. in 1978. International Journal of Radiation Oncology*Biology*Physics, 20, 87-93. http://www.ncbi.nlm.nih.gov/pubmed/1993634 https://doi.org/10.1016/0360-3016(91)90142-Q
[6]
Coia, L., Won, M., Lanciano, R., Marcial, V.A., Martz, K. and Hanks, G. (1990) The Patterns of Care Outcome Study for Cancer of the Uterine Cervix Results of the Second National Practice Survey. Cancer, 66, 2451-2456. https://doi.org/10.1002/1097-0142(19901215)66:12<2451::AID-CNCR2820661202>3.0.CO;2-5
[7]
Hanks, G.E., Herring, D.F. and Kramer, S. (1983) Patterns of Care Outcome Studies Results of the National Practice in Cancer of the Cervix. Cancer, 51, 959-967. https://doi.org/10.1002/1097-0142(19830301)51:5<959::AID-CNCR2820510533>3.0.CO;2-K
[8]
Lanciano, R.M., Won, M., Coia, L.R. and Hanks, G.E. (1991) Pretreatment and Treatment Factors Associated with Improved Outcome in Squamous Cell Carcinoma of the Uterine Cervix: A Final Report of the 1973 and 1978 Patterns of Care Studies. International Journal of Radiation Oncology*Biology*Physics, 20, 667-676. http://www.ncbi.nlm.nih.gov/pubmed/2004942
[9]
Jamema, S.V., Saju, S., Mahantshetty, U., Pallad, S., Deshpande, D.D., Shrivastava, S.K., et al. (2008) Dosimetric Evaluation of Rectum and Bladder Using Image-Based CT Planning and Orthogonal Radiographs with ICRU 38 Recommendations in Intracavitary Brachytherapy. Journal of Medical Physics, 33, 3-8. http://www.ncbi.nlm.nih.gov/pubmed/20041045 https://doi.org/10.4103/0971-6203.39417
[10]
Wachter-Gerstner, N., Wachter, S., Reinstadler, E., Fellner, C., Knocke, T.H., Wambersie, A., et al. (2003) Bladder and Rectum Dose Defined from MRI Based Treatment Planning for Cervix Cancer Brachytherapy: Comparison of Dose-Volume Histograms for Organ Contours and Organ Wall, Comparison with ICRU Rectum and Bladder Reference Point. Radiotherapy & Oncology, 68, 269-276. https://www.sciencedirect.com/science/article/pii/S0167814003001890 https://doi.org/10.1016/S0167-8140(03)00189-0
[11]
Fellner, C., Pötter, R., Knocke, T.H. and Wambersie, A. (2001) Comparison of Radiography- and Computed Tomography-Based Treatment Planning in Cervix Cancer in Brachytherapy with Specific Attention to Some Quality Assurance Aspects. Radiotherapy & Oncology, 58, 53-62. https://www.sciencedirect.com/science/article/pii/S0167814000002826 https://doi.org/10.1016/S0167-8140(00)00282-6
[12]
Mahantshetty, U., Swamidas, J., Khanna, N., Engineer, R., Merchant, N.H. and Shrivastava, S. (2011) Magnetic Resonance Image-Based Dose Volume Parameters and Clinical Outcome with High Dose Rate Brachytherapy in Cervical Cancers—A Validation of GYN GEC-ESTRO Brachytherapy Recommendations. Clinical Oncology, 23, 376-377. http://linkinghub.elsevier.com/retrieve/pii/S0936655511005590 https://doi.org/10.1016/j.clon.2011.02.006
[13]
Nag, S., Cardenes, H., Chang, S., Das, I.J., Erickson, B., Ibbott, G.S., et al. (2004) Proposed Guidelines for Image-Based Intracavitary Brachytherapy for Cervical Carcinoma: Report from Image-Guided Brachytherapy Working Group. International Journal of Radiation Oncology, 60, 1160-1172. https://www.sciencedirect.com/science/article/pii/S0360301604006704 https://doi.org/10.1016/j.ijrobp.2004.04.032
[14]
Bansal, A.K., Semwal, M.K., Sharma, D.N., Thulkar, S., Julka, P.K. and Rath, G.K. (2014) A Patient-Based Dosimetric Study of Intracavitary and Interstitial Brachytherapy in Advanced Stage Carcinoma of the Cervix. Journal of Applied Clinical Medical Physics, 15, 4509. http://www.ncbi.nlm.nih.gov/pubmed/24892331 https://doi.org/10.1120/jacmp.v15i3.4509
[15]
Ren, J., Menon, G., Sloboda, R., Arif, W.R., Haris, B. and Islamiyah, D.I. (2017) Dose Evaluation of Organs at Risk (OAR) Cervical Cancer Using Dose Volume Histogram (DVH) on Brachytherapy Comparative Evaluation of Two Dose Optimization Methods for Image-Guided, Highly-Conformal, Tandem and Ovoids Cervix Brachytherapy Planning Dose Evaluation of Organs at Risk (OAR) Cervical Cancer Using Dose Volume Histogram (DVH) on Brachytherapy. IOP Conf Ser J Phys Conf Ser, 853, 12013. http://iopscience.iop.org/article/10.1088/1742-6596/853/1/012013/pdf