Objective:To compare the efficacy and compliance of the
conventional therapy of iron deficiency anemia (ferrous sulfate) with the new
forms of therapy chewable iron tablets: (iron polymaltose complex) in the
treatment of iron deficiency anemia in pregnant women. Methods: This Randomized Control Trial study included 290
pregnant women with iron deficiency anemia, and they were randomly allocated to acontrol
group who received ferrous sulfate capsules for two months and study group who
received iron polymaltose complex chewable tablets for two months.Complete
Blood Picture (hemoglobin level and hematocrit level) and Serum ferritin level
were done after four and eight weeks to determine the efficacy. In addition,
any complains or side effects had been reported to assess the tolerability of
the drugs.Two-factor repeated-measures analysis of variance
References
[1]
World Health Organization (2001) Iron Deficiency Anemia, Assessment, Prevention, and Control: A Guide for Program Managers.
[2]
Dusch, E. and Elder, L. (2002) Women’s Perceptions of Iron Deficiency and Anemia Prevention and Control in Eight Developing Countries. Social Science & Medicine, 55, 529-544. https://doi.org/10.1016/S0277-9536(01)00185-X
[3]
Adamson, J.W. (2001) Iron Deficiency and Other Hypo Proliferative Anemias. In: Harrison’s Principles of Internal Medicine, 15th Edition, McGraw Hill, 660-666.
[4]
Hurrell, R.F., Furniss, D.C. and Burri, J. (1989) Iron Fortification of Infant Cereals: A Proposal for Use of Ferrous Fumerate or Succinate. The American Journal of Clinical Nutrition, 49, 1274-1282. https://doi.org/10.1093/ajcn/49.6.1274
[5]
Jacobs, P., Wormald, L.A. and Gregory, M.C. (1979) Absorption of Iron Polymaltose and Ferrous Sulphate in Rats and Humans—A Comparative Study. South African Medical Journal, 26, 1065-1072.
[6]
Sharma, J.B. (2003) Nutritional Anemia during Pregnancy in Non-Industrialised Countries. In: Studd, J., Ed., Progress in Obstetrics and Gynecology, Churchill Livingstone, New Delhi, 103-122.
[7]
Klebanoff, M.A., Shiono, P.H. and Selby, J.V. (1991) Anemia and Spontaneous Preterm Birth. American Journal of Obstetrics & Gynecology, 164, 59-63.
https://doi.org/10.1016/0002-9378(91)90626-3
[8]
Allen, L.H. (2000) Anemia and Iron Deficiency: Effects on Pregnancy Outcome. The American Journal of Clinical Nutrition, 71, 1280-1284.
https://doi.org/10.1093/ajcn/71.5.1280s
[9]
Jacobs, P., Johnson, G. and Wood, L. (1984) Oral Iron Therapy in Human Subjects, Comparative Absorption between Ferrous Salts and Iron Polymaltose. Journal of Medicine, 15, 367-377.
[10]
Frewin, R., Henson, A. and Provan, D. (1997) ABC of Clinical Haematology: Iron Deficiency Anemia. BMJ, 314, 360-363. https://doi.org/10.1136/bmj.314.7077.360
[11]
Mills, K.C. and Curry, S.C. (1994) Acute Iron Poisoning. Emergency Medicine Clinics of North America, 12, 397-413.
[12]
Ortiz, R., Toblli, J.E., Romero, J.D., Monterrosa, B., Frer, C., Macagno, E. and Breymann, C. (2011) Efficacy and Safety of Oral Iron(III) Polymaltose Complex versus Ferrous Sulfate in Pregnant Women with Iron-Deficiency Anemia: A Multicenter, Randomized, Controlled Study. The Journal of Maternal-Fetal & Neonatal Medicine, 24, 1347-1352. https://doi.org/10.3109/14767058.2011.599080
[13]
Juarez-Vazquez, J., Bonizzoni, E. and Scotti, A. (2002) Iron Plusfolate Is More Effective than Iron Alone in the Treatment of Iron Deficiency Anemia in Pregnancy: A Randomized, Double Blind Clinical Trial. BJOG, 109, 1009-1014.
https://doi.org/10.1111/j.1471-0528.2002.01378.x
[14]
Khalafallah, A., Dennis, A., Bates, J., Bates, G., Robertson, I.K., Smith, L., Ball, M.J., Seaton, D., Brain, T. and Rasko, J.E. (2010) Intravenous versus Oral Iron for Moderate Iron Deficiency Anemia of Pregnancy. Journal of Internal Medicine, 268, 286-295.
[15]
Makrides, M., Crowther, C.A., Gibson, R.A., Gibson, R.S. and Skeaff, C.M. (2003) Efficacy and Tolerability of Low-Dose Iron Supplements during Pregnancy: A Randomized Controlled Trial. The American Journal of Clinical Nutrition, 78, 145-153. https://doi.org/10.1093/ajcn/78.1.145
