In Vitro Fertilization (IVF) is the treatment for many causes of infertility.
Many studies were done to investigate different factors that can affect the
success rate. This study was conducted to evaluate if cycle day3 (CD3)follicle-stimulating
hormone (FSH)/luteinizing hormone (LH)ratio
can be a predictor for the IVF outcome in young sub-fertile females ≤ 35 years
with normal baseline FSH.This is a retrospective case control study conducted at the Centre of
Fertility and Andrology Care (CFAC) in Egypt where 235 sub-fertile women
underwentIVF. Patients were grouped based on CD3 FSH/LH ratio. Group Aconsisted
of≤35-year-old women with FSH/LH ratio < 2 and group B included≤35-year-old
women
References
[1]
Boivin, J., Bunting, L., Collins, J.A. and Nygren, K.G. (2007) International Estimates of Infertility Prevalence and Treatment-Seeking: Potential Need and Demand for Infertility Medical Care. Human Reproduction, 22, 1506-1512.
https://doi.org/10.1093/humrep/dem046
[2]
Orvieto, R., Meltzer, S., Rabinson, J., Gemer, O., Anteby, E.Y. and Nahum, R. (2008) 'Does Day 3 Luteinizing-Hormone Level Predict IVF Success in Patients Undergoing Controlled Ovarian Stimulation with GnRH Analogues? Fertility and Sterility, 90, 1297-300. https://doi.org/10.1016/j.fertnstert.2007.10.058
[3]
Navot, D., Bergh, P.A., Williams, M.A., Garrisi, G.J., Guzman, I., Sandler, B. and Grunfeld, L. (1991) Poor Oocyte Quality Rather Than Implantation Failure as a Cause of Age-Related Decline in Female Fertility. Lancet, 337, 1375-1377.
https://doi.org/10.1016/0140-6736(91)93060-M
[4]
Broekmans, F.J., Kwee, J., Hendriks, D.J., Mol, B.W. and Lambalk, C.B. (2006) A Systematic Review of Tests Predicting Ovarian Reserve and IVF Outcome. Human Reproduction Update, 12, 685-718. https://doi.org/10.1093/humupd/dml034
[5]
Erdem, M., Erdem, A., Gursoy, R. and Biberoglu, K. (2004) Comparison of Basal and Clomiphene Citrate Induced FSH and Inhibin B, Ovarian Volume and Antral Follicle Counts as Ovarian Reserve Tests and Predictors of Poor ovarian Response in IVF. Journal of Assisted Reproduction and Genetics, 21, 37-45.
https://doi.org/10.1023/B:JARG.0000025936.73125.b4
[6]
Roudebush, W.E., Kivens, W.J. and Mattke, J.M. (2008) Biomarkers of Ovarian Reserve. Biomark Insights, 3, 259-268. https://doi.org/10.4137/BMI.S537
[7]
Mamsen, L.S., Lutterodt, M.C., Andersen, E.W., Byskov, A.G. and Andersen, C.Y. (2011) Germ Cell Numbers in Human Embryonic and Fetal Gonads during the First Two Trimesters of Pregnancy: Analysis of Six Published Studies. Human Reproduction, 26, 2140-2145. https://doi.org/10.1093/humrep/der149
[8]
Kelsey, T.W., Anderson, R.A., Wright, P., Nelson, S.M. and Wallace, W.H. (2012) Data-Driven Assessment of the Human Ovarian Reserve. Molecular Human Reproduction, 18, 79-87. https://doi.org/10.1093/molehr/gar059
[9]
Broekmans, F.J., Scheffer, G.J., Bancsi, L.F., Dorland, M., Blankenstein, M.A. and te Velde, E.R. (1998) Ovarian Reserve Tests in Infertility Practice and Normal Fertile Women. Maturitas, 30, 205-214. https://doi.org/10.1016/S0378-5122(98)00075-9
[10]
de Vet, A., Laven, J.S., de Jong, F.H., Themmen, A.P. and Fauser, B.C. (2002) Antimüllerian Hormone Serum Levels: A Putative Marker for Ovarian Aging. Fertility and Sterility, 77, 357-62. https://doi.org/10.1016/S0015-0282(01)02993-4
[11]
Jirge, P.R. (2011) Ovarian Reserve Tests. Journal of Human Reproductive Sciences, 4, 108-113. https://doi.org/10.4103/0974-1208.92283
[12]
Scott, R.T. and Hofmann, G.E. (1995) Prognostic Assessment of Ovarian Reserve. Fertility and Sterility, 63, 1-11. https://doi.org/10.1016/S0015-0282(16)57287-2
[13]
Perloe, M., Levy, D.P. and Sills, E.S. (2000) Strategies for Ascertaining Ovarian Reserve among Women Suspected of Subfertility. International Journal of Fertility and Women's Medicine, 45, 215-224.
[14]
Tomas, C., Nuojua-Huttunen, S. and Martikainen, H. (1997) Pretreatment Transvaginal Ultrasound Examination Predicts Ovarian Responsiveness to Gonadotrophins in In-Vitro Fertilization. Human Reproduction, 12, 220-223.
https://doi.org/10.1093/humrep/12.2.220
[15]
Lyu, S.W., Kim, J.W., Choi, C.H., Seok, H.H., Yoon, T.K. and Kim, A. (2013) Impact of High Basal FSH/LH Ratio in Women with Normal FSH Levels on In Vitro Fertilization Outcomes. Gynecological Endocrinology, 29, 424-429.
https://doi.org/10.3109/09513590.2012.743002
[16]
Prasad, S., Gupta, T. and Divya, A. (2013) Correlation of the Day 3 FSH/LH Ratio and LH Concentration in Predicting IVF Outcome. Journal of Reproduction & Infertility, 14, 23-28.
[17]
The European Recombinant Human LH Study Group (1998) Recombinant Human Luteinizing Hormone (LH) to Support Recombinant Human Follicle-Stimulating Hormone (FSH)-Induced Follicular Development in LH- and FSH-Deficient Anovulatory Women: A Dose-Finding Study. The Journal of Clinical Endocrinology & Metabolism, 83, 1507-1514.
[18]
Filicori, M., Cognigni, G.E. and Ciampaglia, W. (2003) Effects of LH on Oocyte Yield and Developmental Competence. Human Reproduction, 18, 1357-1358.
https://doi.org/10.1093/humrep/deg266
[19]
Young, K.A., Chaffin, C.L., Molskness, T.A. and Stouffer, R.L. (2003) Controlled Ovulation of the Dominant Follicle: A Critical Role for LH in the Late Follicular Phase of the Menstrual Cycle. Human Reproduction, 18, 2257-2263.
https://doi.org/10.1093/humrep/deg467
[20]
Zeleznik, A.J. (2001) Follicle Selection in Primates: Many Are Called But Few Are Chosen. Biology of Reproduction, 65, 655-659.
https://doi.org/10.1095/biolreprod65.3.655
[21]
Sharma, V., Allgar, V. and Rajkhowa, M. (2002) Factors Influencing the Cumulative Conception Rate and Discontinuation of in Vitro Fertilization Treatment for Infertility. Fertility and Sterility, 78, 40-46.
https://doi.org/10.1016/S0015-0282(02)03160-6
[22]
Creus, M., Penarrubia, J., Fábregues, F., Vidal, E., Carmona, F., Casamitjana, R., Vanrell, J.A. and Balasch, J. (2000) Day 3 Serum Inhibin B and FSH and Age as Predictors of Assisted Reproduction Treatment Outcome. Human Reproduction, 15, 2341-2346. https://doi.org/10.1093/humrep/15.11.2341
[23]
Liu, K.E. and Greenblatt, E.M. (2008) Elevated Day 3 Follicle-Stimulating Hormone/Luteinizing Hormone Ratio > or = 2 Is Associated with Higher Rates of Cancellation in In Vitro Fertilization-Embryo Transfer Cycles. Fertility and Sterility, 90, 297-301. https://doi.org/10.1016/j.fertnstert.2007.06.038
[24]
Hendriks, D.J., Mol, B.W., Bancsi, L.F., Te Velde, E.R. and Broekmans, F.J. (2005) Antral Follicle Count in the Prediction of Poor Ovarian Response and Pregnancy after in Vitro Fertilization: A Meta-Analysis and Comparison with Basal Follicle-Stimulating Hormone Level. Fertility and Sterility, 83, 291-301.
https://doi.org/10.1016/j.fertnstert.2004.10.011
[25]
Ho, J.Y., Guu, H.F., Yi, Y.C., Chen, M.J. and Ho, E.S. (2005) The Serum Follicle-Stimulating Hormone-to-Luteinizing Hormone Ratio at the Start of Stimulation with Gonadotropins after Pituitary Down-Regulation Is Inversely Correlated with a Mature Oocyte Yield and Can Predict “Low Responders”. Fertility and Sterility, 83, 883-888. https://doi.org/10.1016/j.fertnstert.2004.10.040
[26]
Seckin, B., Turkcapar, F. and Ozaksit, G. (2012) Elevated Day 3 FSH/LH Ratio: A Marker to Predict IVF Outcome in Young and Older Women. Journal of Assisted Reproduction and Genetics, 29, 231-236.
https://doi.org/10.1007/s10815-011-9695-5
[27]
Sharif, K., Elgendy, M., Lashen, H. and Afnan, M. (1998) Age and Basal Follicle Stimulating Hormone as Predictors of In Vitro Fertilisation Outcome. British Journal of Obstetrics and Gynaecology, 105, 107-112.
https://doi.org/10.1111/j.1471-0528.1998.tb09360.x
[28]
Thomas, A., Okamoto, S., O’Shea, F., MacLachlan, V., Besanko, M. and Healy, D. (1989) Do Raised Serum Luteinizing Hormone Levels during Stimulation for In-Vitro Fertilization Predict Outcome? British Journal of Obstetrics and Gynaecology, 96, 1328-1332. https://doi.org/10.1111/j.1471-0528.1989.tb03232.x
