The disclosure of many secrets of the genetic code was facilitated by the fact that it was carried out on the basis of mathematical analysis of experimental data: the diversity of genes, their structures and genetic codes. New properties of the genetic code are presented and its most important integral characteristics are established. Two groups of such characteristics were distinguished. The first group refers to the integral characteristics for the areas of DNA, where genes are broken down in pairs and all 5 cases of overlap, allowed by the structure of DNA, were investigated. The second group of characteristics refers to the most extended areas of DNA in which there is no genetic overlap. The interrelation of the established integral characteristics in these groups is shown. As a result, a number of previously unknown effects were discovered. It was possible to establish two functions in which all the over-understood codons in mitochondrial genetic codes (human and other organizations) participate, as well as a significant difference in the integral characteristics of such codes compared to the standard code. Other properties of the structure of the genetic code following from the obtained results are also established. The obtained results allowed us to set and solve one of the new breakthrough problems—the calculation of the genetic code. The full version of the solution to this problem was published in this journal in August 2017.
References
[1]
Ycas, M. (1969) The Biological Codе. North-Holland Publishing, Amsterdam, London, 359 p.
[2]
Ychas, M. (1994) Meaning and Mechanisms.
[3]
Mendel, G. (1866) Versuche über Pflanzenhybriden. Verhandlungen des naturforschenden Vereines in Brünn, 4, 3-47.
[4]
Schrodinger, E. (1944) What Is Life? The Physical Aspect of the Living Cell. University Press, Cambridge.
[5]
Watson, J.D. and Crick, F.H.C. (1953) A Structure for Deoxyribose Nucleic Accid. Nature, 171, 737-738. https://doi.org/10.1038/171737a0
[6]
Watson, J.D. (1968) The Double Helix. A Personal Account of the Discovery of the Structure of DNA. Atheneum, New York.
[7]
Lewin, B. (1997) Genes VI. Oxford University Press, Oxford, 879 p.
[8]
Barrell, B.G., Аir, G.M. and Hutchisoп III, С.А. (1976) Overlapping Genes in Bacteriophage ФХ174. Nature, 264, 34-41. https://doi.org/10.1038/264034a0
[9]
Kozlov, N.N. (1999) Involvement of Each of 64 Сodons in Gene Overlappings. Doklady Biochemistry, 367, 126-128.
[10]
Sanger, F., Coulson, A.R., Friedmann, T., Air, G.M., Barrell, B.G., Brown, N.L., Fiddes, J.C., Hutchison III, C.A., Slocombe, P.M. and Smith, M. (1978) The Nucleotide Sequence of Bacteriophage ФХ174. Journal of Molecular Biology, 125, 225-246.
https://doi.org/10.1016/0022-2836(78)90346-7
[11]
Nakayama, T., Asai, S., Takahashi, Y. and Nishida, Y. (2007) Overlapping of Genes in the Human Genome. Nevill Juvenile Bonfire Society, 3, 14-19.
[12]
Guyader, M., Emerman, M., Sonigo, P., Clavel, F., Montagnier, L. and Alizon, M. (1987) Genome Organization and Transactivation of the Human Immunodeficiency Virus Type 2. Nature, 326, 662-669. https://doi.org/10.1038/326662a0
[13]
Barrell, B.G., Bankier, A.T. and Drouin, J. (1979) A Different Genetic Code in Human Mitochondria. Nature, 282, 189-194. https://doi.org/10.1038/282189a0
[14]
Kozlov, N.N. (2014) One Integral Characteristic of the Set of Genetic Codes. The Property of All Known Natural Codes. Mathematical Models and Computer Simulations, 6, 622-630. https://doi.org/10.1134/S2070048214060064
[15]
Fiers, W., Contreras, R., Duerinck, F., Haegeman, G., Iserentant, D., Merregaert, J., Min Jou, W., Molemans, F., Raeymaekers, A., Van den Berghe, A., Volckaert, G. and Ysebaert, M. (1976) Complete Nucleotide Sequence of Bacteriophage MS2 RNA: Primary and Secondary Structure of the Replicase Gene. Nature, 260, 500-507.
https://doi.org/10.1038/260500a0
[16]
Anderson, S., Bankier, A.T., Barrell, B.G., de Bruijn, M.H.L., Coulson, A.R., Drouin, J., Eperon, I.C., Nierlich, D.P., Roe, B.A., Sanger, F., Schreier, P.H., Smith, A.J.H., Staden, R. and Young, I.G. (1981) Sequence and Organization of the Human Mitochondrial Genome. Nature, 290, 457-464. https://doi.org/10.1038/290457a0
[17]
Clary, D.O. and Wolstenholme, D.R. (1985) The Mitochondrial DNA Molecule of Drosophila Yakuba: Nucleotide Sequence, Gene Organization, and Genetic Code. Journal of Molecular Evolution, 22, 252-271. https://doi.org/10.1007/BF02099755
[18]
Cantatore, P., Roberti, M., Rainaldi, G., Gadaletа, M.N. and Saccone, C. (1989) The Complete Nucleоtide Sequence, Gene Organization, and Genetic Code of the Mitochondrial Genome of Paracentrotus lividus. The Journal of Biological Chemistry, 264, 10965-10975.
[19]
Crozier, R.H. and Crozier, Y.C. (1993) The Mitochondrial Genome of the Honeybee Apis mellifera: Complete Sequence and Genome Organization. Genetics, 133, 97-117.
[20]
Kozlov, N.N. (2011) Integral Characteristics of Genetic Code. Mathematical Models and Computer Simulations, 3, 123-134. https://doi.org/10.1134/S2070048211020050
[21]
Kozlov, N.N. (2013) Some New Characteristics of Large Genomes. Mathematical Models and Computer Simulations, 5, 220-228.
https://doi.org/10.1134/S2070048213030071
[22]
Alberts, B., Bray, D., Lewis, J., Raff, M., Roberts, K. and Watson, J. (1994) Molecular Biology of the Cell. Gorland Publishing, Inc., New York, London, 1294 p.
Kozlov, N.N. (2015) Three Function Ambiguity from the Sets Generated by the Genetic Code. Mathematical Models and Computer Simulations, 7, 401-408.
https://doi.org/10.1134/S2070048215050063
[25]
Kozlov, N.N. (2013) One Function of Ambiguities from the Sets Generated by the Genetic Code. Mathematical Models and Computer Simulations, 5, 17-24.
https://doi.org/10.1134/S2070048213010067
[26]
Kozlov, N.N. (2014) Genetic Code: A Mathematician’s Point of View. Palamarium Academic, Hamburg, 336 p.
[27]
Kozlov, N.N. (2017) Computation of the Genetic Code: Full Version. Journal Computer and Communications, 5, 78-94. https://doi.org/10.4236/jcc.2017.510008
[28]
Kozlov, N.N., Kugushev, E.I. and Eneev, T.M. (2017) Genetic Code Potential for Overlaps of Six and Three Genes. Doklady Mathematics, 95, 161-163.
https://doi.org/10.1134/S1064562417020168
[29]
Kozlov, N.N., Kugushev, E.I. and Eneev, T.M. (2017) Mathematical Analysis of Codons That Stop Protein Synthesis. Doklady Mathematics, 96, 571-573.
https://doi.org/10.1134/S1064562417060102