Melanocytic matricoma is a very rare adnexal tumor that recapitulates the anagen hair follicle bulb. Few cases of malignant melanocytic matricoma have been reported, thus criteria for malignant potential have not been previously reviewed. We report a case of an 81 year old male that was originally diagnosed as atypical melanocytic matricoma. The site was re-excised with a small focus of residual tumor, but all margins were negative. The re-excision site healed without complication. However, two years after the original biopsy, a new 8 mm firm nodule appeared at the re-excision site, which was subsequently diagnosed as malignant melanocytic matricoma (MMM). In the following paper we will report a new case of MMM and review potential criteria that could be used in the future to establish malignant potential.
References
[1]
Carlson, J.A., Healy K., Slominski, A. and Mihm, M. (1999) Melanocytic Matricoma: A Report of Two Cases of a New Entity. American Journal of Dermatopathology, 21, 344-349. https://doi.org/10.1097/00000372-199908000-00006
[2]
Carlson, J.A., Slominski, A. and Mihm, M. (2003) What Are the Clinicopathologic Features of Matricoma? American Journal of Dermatopathology, 25, 446-447.
https://doi.org/10.1097/00000372-200310000-00015
[3]
Pagliarello C., Stanganelli I., Ricci R., Feliciani C. and Di Nuzzo S. (2017) A Pinkish-Blue Exophytic Nodule on the Arm of an Elderly Man: Melanocytic Matricoma. Acta Dermatologica Venereologica, 97, 1261-1262.
https://doi.org/10.2340/00015555-2740
[4]
Monteagudo, C., Fernandez-Figueras, M., San Juan, J., Lopez, D. and Carda, C. (2003) Matrical Carcinoma with Prominent Melanocytic Hyperplasia (Malignant Melanocytic Matricoma?). A Report of Two Cases. American Journal of Dermatopathology, 25, 485-489. https://doi.org/10.1097/00000372-200312000-00005
[5]
Jani, P., Chetty, R. and Ghazarian D.M. (2008) An Unusual Composite Pilomatrix Carcinoma with Intralesional Melanocytes: Differential Diagnosis, Immunohistochemical Evaluation, and Review of the Literature. American Journal of Dermatopathology, 39, 174-177. https://doi.org/10.1097/DAD.0b013e318165b8fe
[6]
Limarporn, L., Lourie, R., Pool, L. and Wong, D. (2012) Malignant Melanocytic Matricoma: A Case Report and Review of the Literature. Pathology, 44, S87.
https://doi.org/10.1016/S0031-3025(16)32844-6
[7]
Ardakani, N.M., Palmer, D.L.G. and Wood, B.A. (2016) Malignant Melanocytic Matricoma: A Report of 2 Cases and Review of the Literature. American Journal of Dermatopathology, 38, 33-38. https://doi.org/10.1097/DAD.0000000000000329
[8]
Ji, C., Zhang, Y., Hler, P. and Guo, Y. (2017) Melanocytic Matrical Carcinoma Mimicking Melanoma. American Journal of Dermatopathology, 39, 903-906.
https://doi.org/10.1097/DAD.0000000000000771
[9]
Ackerman, A.B., De Viragh, P.A. and Chongchitnant, N. (1993) Pilomatricoma and Matricoma. In: Neoplasms with Follicular Differentiation, Lea&Febinger, Philadelphia, PA, 475-506.
[10]
Islam, M.N., Bhattacharyya, I., Proper, S.A., Glanz, S.M., Vega, J.M. and Hassanein, A.M. (2007) Melanocytic Matricoma: A Distinctive Clinicopathologic Entity. Dermatological Surgery, 33, 857-863.
https://doi.org/10.1097/00042728-200707000-00015
[11]
Cartaginese, F. and Sidoni, A. (2010) Melanocytic Matricoma. Report of a Further Case with Clinicopathological and Immunohistochemical Findings, Differential Diagnosis and Review of Literature. Histology and Histopathology, 25, 713-717.
[12]
Rizzardi, C., Brollo, A., Colonna, A., Brutto, R.L. and Melato, M. (2002) A Tumor with Composite Pilo-Folliculosebaceous Differentiation Harboring a Recently Described New Entity-Melanocytic Matricoma. American Journal of Dermatopathology, 24, 493-497. https://doi.org/10.1097/00000372-200212000-00007
[13]
Resnick, K.S. (2003) Is Melanocytic Matricoma a Bona Fide Entity or Is It Just One Type of Matricoma? American Journal of Dermatopathology, 25, 166-167.
https://doi.org/10.1097/00000372-200304000-00014
[14]
Rizzardi, C, and Melato, M. (2003) Splitting Hairs in Hair Matrix Tumors! Author’s Reply. American Journal of Dermatopathology, 25, 166-167.
https://doi.org/10.1097/00000372-200304000-00015
[15]
Tallon, B. and Cerroni, L. (2010) Where Pigmented Pilomatricoma and Melanocytic Matricoma Collide? American Journal of Dermatopathology, 32, 769-773.
https://doi.org/10.1097/DAD.0b013e3181d88d15
[16]
Nikaido, M., Yamada, M., Konno, T., Hara, K., Yamamoto, T. and Suzuki, T. (2013) Agminated Pigmented Matricoma: A Case of a Unique Tumor with a Multifocal Appearance Composed of Neoplastic Matrical Cells with a Significant Component of Melanocytes. Journal of Cutaneous Pathology, 40, 823-828.
https://doi.org/10.1111/cup.12185
[17]
Tanboon,J., Manonukul, J. and Pattanaprichakul, P. (2014) Melanocytic Matricoma: Two Cases of a Rare Entity in Woman. Journal of Cutaneous Pathology, 41, 775-782. https://doi.org/10.1111/cup.12345
[18]
Battistella, M., Carlson, J.A., Osio, A., Langbein, L. and Cribier, B. (2014) Skin Tumors with Matrical Differentiation: Lessons from Hair Keratins, Beta-Catenin and PHLDA-1 Expression. Journal of Cutaneous Pathology, 41, 427-436.
https://doi.org/10.1111/cup.12313
[19]
Zussman, J., Sheth, S., Ra, S.H. and Binder, S.W. (2011) Melanocytic Matricoma with Melanocytic Atypia: Report of a Unique Case and Review of the Literature. American Journal of Dermatopathology, 33, 508-512.
https://doi.org/10.1097/DAD.0b013e3181ec711c
[20]
Rodic, N., Taube, J.M., Manson, P., Patel, M., Patterson, J.W. and Erdag, G. (2013) Locally Invasive Dermal Squamomelanocytic Tumor with Matrical Differentiation: A Peculiar Case with Review of the Literature. American Journal of Dermatopathology, 35, 72-76. https://doi.org/10.1097/DAD.0b013e31827d989c
[21]
Winslow, C.Y., Camacho, I. and Nousari, C.H. (2017) Melanocytic Matricoma with Consumption of the Epidermis: An Atypical Histologic Attribute or a Malignant Variant? American Journal of Dermatopathology, 39, 907-909.
https://doi.org/10.1097/DAD.0000000000000803
