The use of umbilical cord blood as an alternative to
bone marrow as a source of haematopoietic stem cells for the treatment of
certain diseases has been on an increase since the first transplantation of
umbilical cord-derived stem cells in 1988. In this paper, 6 of the latest case
studies about the use of such stem cells have been discussed and are used as
evidence to confirm the potential use of the umbilical cord as a source of
haematopoietic stem cells for transplantation as treatment to various diseases.
The debate over whether umbilical cord blood should be stored and why public
banking facilities are preferred over those that are private have also been
discussed in this paper.
References
[1]
Forraz, N. and McGuckin, C.P. (2011) The Umbilical Cord: A Rich and Ethical Stem Cell Source to Advance Regenerative Medicine. Cell Proliferation, 44, 60-69. https://doi.org/10.1111/j.1365-2184.2010.00729.x
[2]
Agius, C. and Blundell, R. (2012) The Cutting Edge in Stem Cell Medical Applications. Research Journal of Medical Sciences, 2, 47-50.
[3]
Mckenna, D.H., Kadidlo, D.M., Mccullough, J. and Regan, D.M. (2011) Umbilical Cord Blood. In: Roback, J.D., Grossman, B.J., Harris, T. and Hillyer, C.D., Eds., Technical Manual. American Association of Blood Banks, Bethesda, 823-847.
[4]
Pace, P. and Blundell, R. (2016) Stem Cells: Daddy or Chips?—An Up-to-Date Review on Ground-Breaking Discoveries in Stem Cell Research with Special Attention to iPSC Applications in Osteoarthritis. Stem Cell Discovery, 6, 39-44. https://doi.org/10.4236/scd.2016.61004
[5]
Conconi, M.T., Di Liddo, R., Tommasini, M., Calore, C. and Parnigotti, P.P. (2011) Phenotype and Differentiation Potential of Stromal Populations Obtained from Various Zones of Human Umbilical Cord: An Overview. The Open Tissue Engineering and Regenerative Medicine Journal, 4, 6-20.
[6]
Ziaei, M., Zhang, J., Patel, D. and McGhee, C.N.J. (2017) Umbilical Cord Stem Cells in the Treatment of Corneal Disease. Survey of Ophthalmology, 62, 803-815. https://doi.org/10.1016/j.survophthal.2017.02.002
[7]
Knudtzon, S. (1974) In Vitro Growth of Granulocytic Colonies from Circulating Cells in Human Cord Blood. Blood, 43, 357-361.
[8]
Bieback, K., Kern, S., Kluter, H. and Eichler, H. (2004) Critical Parameters for the Isolation of Mesenchymal Stem Cells from Umbilical Cord Blood. Stem Cells, 22, 625-634. https://doi.org/10.1634/stemcells.22-4-625
[9]
Erices, A., Conget, P. and Minguell, J.J. (2000) Mesenchymal Progenitor Cells in Human Umbilical Cord Blood. British Journal of Haematology, 109, 235-242. https://doi.org/10.1046/j.1365-2141.2000.01986.x
[10]
Goodwin, H.S., Bicknese, A.R., Chien, S., Bogucki, B.D., Oliver, D.A., Quinn, C.O. and Wall, D.A. (2001) Multi-Lineage Differentiation Activity by Cells Isolated from Umbilical Cord Blood: Expression of Bone, Fat, and Neural Markers. Biology Blood and Marrow Transplantation, 7, 581-588. https://doi.org/10.1053/bbmt.2001.v7.pm11760145
[11]
Kögler, G., Sensken, S., Airey, J.A., Trapp, T., Müschen, M., Feldhahn, N., Liedtke, S., Sorg, R.V., Fischer, J., Rosenbaum, C., Greschat, S., Knipper, A., Bender, J., Degistirici, O., Gao, J., Caplan, A.I., Colletti, E.J., Almedia-Porada, G., Müller, H.W., Zanjani, E. and Wernet, P. (2004) A New Human Somatic Stem Cell from Placental Cord Blood with Intrinsic Pluripotent Differentiation Potential. The Journal of Experimental Medicine, 200, 123-135. https://doi.org/10.1084/jem.20040440
[12]
Lee, O.K., Kuo, T.K., Chen, W.M., Lee, K.D., Hsieh, S.L. and Chen, T.H. (2004) Isolation of Multipotent Mesenchymal Stem Cells from Umbilical Cord Blood. Blood, 103, 1669-1675. https://doi.org/10.1182/blood-2003-05-1670
Wexler, S.A., Donaldson, C., Denning-Kendall, P., Rice, C., Bradley, B. and Hows, J.M. (2003) Adult Bone Marrow Is a Rich Source of Human Mesenchymal “Stem” Cells But Umbilical Cord and Mobilized Adult Blood Are Not. British Journal of Haematology, 121, 368-374. https://doi.org/10.1046/j.1365-2141.2003.04284.x
[15]
Romanov, Y.A., Svintsitskaya, V.A. and Smirnov, V.N. (2003) Searching for Alternative Sources of Postnatal Human Mesenchymal Stem Cells: Candidate MSC-Like Cells from Umbilical Cord. Stem Cells, 21, 105-110. https://doi.org/10.1634/stemcells.21-1-105
[16]
Mareschi, K., Biasin, E., Piacibello, W., Aglietta, M., Madon, E. and Fagioli, F. (2001) Isolation of Human Mesenchymal Stem Cells: Bone Marrow versus Umbilical Cord Blood. Haematologica, 86, 1099-1100.
[17]
Cassar, P. and Blundell, R. (2016) The Use of Umbilical Stem Cells. Open Journal of Pathology, 6, 41-56. https://doi.org/10.4236/ojpathology.2016.61007
[18]
Rocha, V., Wagner, J.E.Jr., Sobocinski, K.A., Klein, J.P., Zhang, M., Horowitz, M.M. and Gluckman, E. (2000) Graft-versus-Host Disease in Children Who Have Received a Cord-Blood or Bone Marrow Transplant from an HLA-Identical Sibling. The New England Journal of Medicine, 342, 1846-1854. https://doi.org/10.1056/NEJM200006223422501
[19]
Rubinstein, P., Carrier, C., Scaradavou, A., Kurtzberg, J., Adamson, J., Migliaccio, A.R., Berkowitz, R.L., Cabbad, M., Dobrila, N.L., Taylor, P.E., Rosenfield, R.E. and Stevens, C.E. (1998) Outcomes among 562 Recipients of Placental-Blood Transplants from Unrelated Donors. The New England Journal of Medicine, 339, 1566-1577. https://doi.org/10.1056/NEJM199811263392201
[20]
Gonzalez-Ryan, L., Van Syckle, K., Coyne, K.D. and Glover, N. (2000) Umbilical Cord Blood Banking: Procedural and Ethical Concerns for This New Birth Option. Pediatric Nursing, 26, 105-110.
[21]
Percer, B. (2009) Umbilical Cord Blood Banking: Helping Parents Make Informed Choices. Nursing for Women’s Health, 13, 216-223. https://doi.org/10.1111/j.1751-486X.2009.01422.x
[22]
Rogers, I. and Casper, R.F. (2004) Umbilical Cord Blood Stem Cells. Best Practice & Research: Clinical Obstetrics & Gynaecology, 18, 893-908. https://doi.org/10.1016/j.bpobgyn.2004.06.004
[23]
Weiss, M.L. and Troyer, D.L. (2006) Stem Cells in the Umbilical Cord. Stem Cell Reviews and Reports, 2, 155-162. https://doi.org/10.1007/s12015-006-0022-y
[24]
Jeong, J.H. (2008) Adipose Stem Cells as a Clinically Available and Effective Source of Adult Stem Cell Therapy. International Journal of Stem Cells, 1, 43-48. https://doi.org/10.15283/ijsc.2008.1.1.43
[25]
Lindroos, B., Suuronen, R. and Miettinen, S. (2011) The Potential of Adipose Stem Cells in Regenerative Medicine. Stem Cell Reviews and Reviews and Reports, 7, 269-291. https://doi.org/10.1007/s12015-010-9193-7
[26]
Gonzalez-Rey, E., Anderson, P., Gonzalez, M.A., Rico, L., Buscher, D. and Delgado, M. (2009) Human Adult Stem Cells Derived from Adipose Tissue Protect against Experimental Colitis and Sepsis. Gut, 58, 929-939. https://doi.org/10.1136/gut.2008.168534
[27]
Gonzalez-Rey, E., Gonzalez, M.A., Varela, N., O’Valle, F., Hernandez-Cortes, P., Rico, L., Büscher, D. and Delgado, M. (2010) Human Adipose-Derived Mesenchymal Stem Cells Reduce Inflammatory and T Cell Responses and Induce Regulatory T Cells in Vitro in Rheumatoid Arthritis. Annals of the Rheumatic Diseases, 69, 241-248. https://doi.org/10.1136/ard.2008.101881
[28]
Watt, S.M. and Contreras, M. (2005) Stem Cell Medicine: Umbilical Cord Blood and Its Stem Cell Potential. Seminars in Fetal and Neonatal Medicine, 10, 209-220. https://doi.org/10.1016/j.siny.2005.02.001
[29]
Gluckman, E., Broxmeyer, H.E., Auerbach, A.D., Friendman, H.S., Douglas, G.W., Devergie, A., Esperou, H., Thierry, D., Socie, G., Lehn, P., Cooper, S., English, D., Kurtzberg, J., Bard, J. and Boyse, E.A. (1989) Hematopoietic Reconstitution in a Patient with Fanconi’s Anemia by Means of Umbilical-Cord Blood from an HLA-Identical Sibling. The New England Journal of Medicine, 321, 1174-1178. https://doi.org/10.1056/NEJM198910263211707
[30]
Smith, F.O. and Thomson, B.G. (2000) Umbilical Cord Blood Collection, Banking, and Transplantation: Current Status and Issues Relevant to Perinatal Caregivers. Birth, 27, 127-135. https://doi.org/10.1046/j.1523-536x.2000.00127.x
[31]
Kurtzberg, J., Graham, M., Casey, J., Olson, J., Stevens, C.E. and Rubinstein, P. (1994) The Use of Umbilical Cord Blood in Mismatched Related and Unrelated Hemopoietic Stem Cell Transplantation. Blood Cells, 20, 275-283.
[32]
Wang, X., Yin, X., Sun, W., Bai, J., Shen, Y., Ao, Q., Gu, Y. and Liu, Y. (2017) Intravenous Infusion Umbilical Cord-Derived Mesenchymal Stem Cell in Primary Immune Thrombocytopenia: A Two-Year Follow-Up. Experimental and Therapeutic Medicine, 13, 2255-2258. https://doi.org/10.3892/etm.2017.4229
[33]
Psaila, B. and Bussel, J.B. (2008) Refractory Immune Thrombocytopenic Purpura: Current Strategies for Investigation and Management. British Journal of Haematology, 143, 16-26. https://doi.org/10.1111/j.1365-2141.2008.07275.x
[34]
Mallhi, K., Dix, D.B., Niederhoffer, K.Y., Armstrong, L. and Rozmus, J. (2016) Successful Umbilical Cord Blood Hematopoietic Stem Cell Transplantation in Pediatric Patients with MDS/AML Associated with Underlying GATA2 Mutations: Two Case Reports and Review of Literature. Pediatric Transplantation, 20, 1004-1007. https://doi.org/10.1111/petr.12764
[35]
Zhang, C., Yin, X., Zhang, J., Ao, Q., Gu, Y. and Liu, Y. (2017) Clinical Observation of Umbilical Cord Mesenchymal Stem Cell Treatment of Severe Idiopathic Pulmonary Fibrosis: A Case Report. Experimental and Therapeutic Medicine, 13, 1922-1926. https://doi.org/10.3892/etm.2017.4222
[36]
Kim, H.S., Lee, J.H., Roh, K.H., Jun, H., Kang, K.S. and Kim, T.Y. (2017) Clinical Trial of Human Umbilical Cord Blood-Derived Stem Cells for the Treatment of Moderate-to-Severe Atopic Dermatitis: Phase I/IIa Studies. Stem Cells, 35, 248-255. https://doi.org/10.1002/stem.2401
[37]
Larsen, F.S. and Hanifin, J.M. (2012) Epidemiology of Atopic Dermatitis. Immunology and Allergy Clinics of North America, 22, 1-24. https://doi.org/10.1016/S0889-8561(03)00066-3
[38]
Hoare, C., Li Wan Po, A. and Williams, H. (2000) Systematic Review of Treatments for Atopic Eczema. Health Technology Assessment, 4, 1-191.
[39]
Kassab, M.M. and Cohen, R.E. (2003) The Etiology and Prevalence of Gingival Recession. The Journal of the American Dental Association, 134, 220-225. https://doi.org/10.14219/jada.archive.2003.0137
[40]
Zanwar, K., Kumar Ganji, K. and Bhongade, M.L. (2017) Efficacy of Human Umbilical Stem Cells Cultured on Polylactic/Polyglycolic Acid Membrane in the Treatment of Multiple Gingival Recession Defects: A Randomized Controlled Clinical Study. Journal of Dentistry (Shiraz), 18, 95-103.
[41]
Phillips, C.D., Wongsaisri, P., Htut, T. and Grossman, T. (2017) Purified Umbilical Cord Derived Mesenchymal Stem Cell Treatment in a Case of Systemic Lupus Erythematosus. Clinical and Translational Medicine, 6, 31. https://doi.org/10.1186/s40169-017-0161-6
[42]
Rao, M., Ahrlund-Richter, L. and Kaufman, D.S. (2012) Concise Review: Cord Blood Banking, Transplantation and Induced Pluripotent Stem Cell: Success and Opportunities. Stem Cells, 30, 55-60. https://doi.org/10.1002/stem.770
[43]
Rubinstein, P., Rosenfield, R.E., Adamson, J.W. and Stevens, C.E. (1993) Stored Placental Blood for Unrelated Bone Marrow Reconstitution. Blood, 81, 1679-1690.
[44]
Martin, A. and Badell, M. (2014) Umbilical Cord Blood Banking. Topics in Obstetrics & Gynecology, 34, 1-5. https://doi.org/10.1097/01.PGO.0000452207.26653.05
Fisk, N.M., Roberts, I.A., Markwald, R., Mironov, V. (2005) Can Routine Commercial Cord Blood Banking Be Scientifically and Ethically Justified? PLOS Medicine, 2, e44. https://doi.org/10.1371/journal.pmed.0020044
[47]
Annas, G.J. (1999) Waste and Longing—The Legal Status of Placental-Blood Banking. The New England Journal of Medicine, 340, 1521-1524. https://doi.org/10.1056/NEJM199905133401923
[48]
Herlihy, M.M. and Delpapa, E.H. (2013) Obstetricians and Their Role in Cord Blood Banking: Promoting a Public Model. Obstetrics & Gynecology, 121, 851-855. https://doi.org/10.1097/AOG.0b013e31828882aa
[49]
Ballen, K., Barker, J., Stewart, S., Greene, M. and Lane, T. (2008) ASBMT Committee REPORT: Collection and Preservation of Cord Blood for Personal Use. Biology of Blood and Marrow Transplantation, 14, 356-363. https://doi.org/10.1016/j.bbmt.2007.11.005
[50]
Pandey, D., Kaur, S. and Kamath, A. (2016) Banking Umbilical Cord Blood (UCB) Stem Cells: Awareness, Attitude and Expectations of Potential Donors from One of the Largest Potential Repository (India). PLoS ONE, 11, e0155782. https://doi.org/10.1371/journal.pone.0155782
