Background: The infection with HIV has been related to neurological disorders
that are very frequent, since this virus crosses the blood-brain barrier
and enters the CNS, thus affecting its neurological development. About 50% -
90% of infected patients, with an average age of onset from 19 months to 3
years old may present some types of neurological alteration during the course
of the disease. Currently in Guatemala, there are no researches that show
changes in the neurodevelopment of patients infected with HIV. Objective:
To identify neurodevelopment of pediatric patients infected with the HIV,
taking into consideration clinical and epidemiological characteristics. Materials
and Methods: Fifty-six patients, who were under 8 years and 6 months
of age, that met the inclusion criteria (confirmed diagnosis of HIV), were
evaluated through neurodevelopment test (Bayley Test and McCarthy’s Scale)
during the months of May and June of 2016. Results: Within the neurodevelopment
evaluation, it was discovered that between 36% and 54% of evaluated
patients that were 3 years and 6 months to 8 years and 6 months old, presented
alterations in more than one area of neurodevelopment, correlating it
with studies performed in other countries with 30% - 70% of neurological affection. Conclusions-All infected patients have alterations in more than one
area of neurodevelopment. The most affected areas of neurodevelopment
were the verbal, numerical and cognitive areas.
References
[1]
Puthanakit, T., Ananworanich, J., Vonthanak, S., Kosalaraksa, P., Hansudewechakul, R., et al. (2013) Cognitive Function and Neurodevelopmental Outcomes in HIV Infected Children Older Than 1 Year of Age Randomized to Early versus Deferred Antiretroviral Therapy: The PREDICT Neurodevelopmental Study, Cambolia and Thailand.
[2]
Mancini, J. and Chabrol, B. (2010) Neurological Development. University Hospital Timone-Enfants, France.
[3]
Velasco, M. and Losa, J. (2010) Neurological Manifestations of the Patient with HIV Infection. Hospital Universitario Fundación Alcorcón, Madrid.
[4]
álvarez, M., Alfonso, J. and Pineiro, B. (2009) Neurologic Manifestations in AIDS Patients. Hospital Clinical-Surgical University. CMDTE. Faustino Peréz Hernández. Matanzas.
[5]
Bernal Cano, F. (2008) Human Immunodeficiency Virus HIV and Nervous System. General Principles, 18.
[6]
Arribas, M., García, J.E., Núnez, L. and Gómez, R. (2009) Neurological Manifestations of the Patient with HIV Infection.
[7]
Violari, A. (2007) Treating HIV-Infected Infants Early Helps Them Live Longer. South African Clinical Trial Modified Because of Initial Data, National Institutes of Health, Bethesda.
[8]
González, F., Pérez, E., Ruiz, N., Acosta, P., Hernández, M., et al. (2007) Neurological Manifestations in Mexican Pediatric and Adolescent Patients Infected with HIV/AIDS. Experience in the Hospital Infantil the México Federico Gómez. Medigraphic [Online Journal].
[9]
Astrulla, J., Cáceres, B. and Revilla, C. (2009) VIH: Vertical Transmission and Neurological Syndrome in Infants. Rev. Científica de Ciencia Médica v.12 n.2 Cochabamba.
[10]
Ministry of Public Health and Social Assistance (2012) Estimates and Projections of HIV and Advanced HIV. National Center of Epidemiology, Guatemala.
[11]
Munoz, J.A. (2008) Neuro-SIDA en el nino.
[12]
Palma, A. (2017) Neurodevelopment in Children under 8 Years and 6 Months with HIV, Roosevelt Hospital, Guatemala, June 2017. Undergraduate Thesis, University Rafael Landívar, Guatemala City.
[13]
González Colorado, M.J. and Pocón Pocón, E.F. (2011) Risk Factors Associated with HIV Infection in Pediatrics: Case-Control Study in Children under 60 Months, Performed at Roosevelt Hospital, Department of Pediatrics and the Hospital for Rehabilitation and Infectious Childhood Diseases of Guatemala City during 2008-2010. Undergraduate Thesis, Universidad de San Carlos de Guatemala, Facultad de Ciencias Médicas.
[14]
Pilar, K.M. (2004) Neurodevelopment in Young Children Exposed to HIV. UCES, Argentina.
[15]
Rodríguez, S., Scrigni, A. and García, A.P. (2009) Highly Active Antiretroviral Therapy in HIV Seropositive Children. Disease Progression by Baseline Clinical, Immunological and Virological Status. Archivos Argentinos de Pediatria, v.107 n.3 Buenos Aires.
[16]
Gonzalo, M.D. (2010) Neurological Complications Associated with HIV Infection.
[17]
World Health Organization (2014) Antiretroviral Treatment in the Spotlight: A Public Health Analysis in Latin America and the Caribbean.
[18]
Czornyj, L.A. (2006) Encephalopathy in Children Infected by Vertically Transmitted Human Inmunodeficiency Virus. Revista De Neurologia, 42, 743-753.
[19]
Van Rie, A., Mupuala, A. and Dow, A. (2008) Impact of the HIV/AIDS Epidemic on the Neuro-Development of Preschool-Aged Children in Kinshasa, Democratic Republic of the Congo. Pediatrics, 122, e123-e128.
https://doi.org/10.1542/peds.2007-2558
[20]
Selik, R., Mokotoff, E., et al. (2014) Revised Surveillance Case Definition for HIV Infection—United States. Recommendations and Reports, 63, 1-10.
[21]
Samayoa, B., Anderson, A., Grazioso, C., Rivera, B.E., Harrison, M., et al. (2009) Experience of a Pediatric HIV Clinic in Guatemala City. Revista Panamericana de Salud Pública, 25, 51-55. https://doi.org/10.1590/S1020-49892009000100008
[22]
Laughton, B., Cornell, M., Boivin, M. and Van Rie, A. (2013) Neurodevelopment in Perinatally HIV-Infected Children: A Concern for Adolescence. Journal of the International AIDS Society, 16, 18603.
[23]
OPS (2009) Definition of the WHO Case of HIV Infection for the Purpose of Surveillance and Review of Clinical Staging and Immunological Classification of the HIV-Related Disease in Adults and Children.
[24]
Castillo, J.A. (2014) Infection Due to HIV/AIDS in the Current World. MediSan, 18, 117-138.
[25]
Walker, S. and Pierre, R. (2013) Neurocognitive Function in HIV-Positive Children in a Developing Country. International Journal of Infectious Diseases, 17, e862-e867. https://doi.org/10.1016/j.ijid.2013.02.014
[26]
ONUSIDA/OMS (2009) Joint United Nations Program on HIV/AIDS and the World Health Organization. Situation of the AIDS Epidemic.
[27]
Ministry of Education, Guatemala (2013) National System of Educational Indicators.
[28]
Organización Mundial de la Salud (2013) The Use of Antiretroviral Drugs for Treating and Preventig HIV Infection.