Magnesium (Mg) and its alloys are one of a novel kind of biodegradable metallic implants which attracted much fundamental research to develop its clinical application. Nevertheless, it has more restrictions in biomedical applications because it degrades too fast at the early stage after implantation, thus commonly leading to some problems such as early fast mechanical loss, hydric bubble aggregation, gap formation between the implants and the tissue. This work aims to study the effect of 0.5 wt% Sb addition on the microstructure, mechanical properties and degradation behavior of as cast Mg-4wt% Zn alloy. The evaluation process was conducted using optical and scanning electron microscopy, X-ray diffraction, tensile and compression tests, in addition to a corrosion study by immersing in simulated body fluid (SBF). Results showed that Sb refines the grain size of the base alloy and also enhances its mechanical properties and degradation rate as well. These were due to the formation of the secondary phase of Mg3Sb2. To get better degradation rate, the Mg-4wt% Zn and Mg-4wt% Zn-0.5wt% Sb alloys are coated with Ca-P using autocatalytic technique. The results demonstrated that the formed coat layer improves the degradation rate of samples under the condition of this study. The current study shows that Mg-4wt% Zn-0.5wt% Sb alloy has good mechanical properties and when it coated by Ca-P, it gave a better corrosion resistance that makes it ideal for biodegradable medical application.
References
[1]
Gu, X., Zheng, Y., Cheng, Y., Zhong, S. and Xi, T. (2009) In vitro Corrosion and Biocompatibility of Binary Magnesium Alloys. Biomaterials, 30, 484-498. https://doi.org/10.1016/j.biomaterials.2008.10.021
[2]
Witte, F., Kaese, V., Haferkamp, H., Switzer, E., Meyer-Lindenberg, A., Wirth, C. and Windhagen, H. (2005) In vivo Corrosion of Four Magnesium Alloys and the Associated Bone Response. Biomaterials, 26, 3557-3563. https://doi.org/10.1016/j.biomaterials.2004.09.049
[3]
Song, G. (2007) Control of Biodegradation of Biocompatable Magnesium Alloys. Corrosion Science, 49, 1696-1701. https://doi.org/10.1016/j.corsci.2007.01.001
[4]
Salleh, E.M., Ramakrishnan, S. and Hussain, Z. (2016) Synthesis of Biodegradable Mg-Zn Alloy by Mechanical Alloying: Effect of Milling Time. Procedia Chemistry, 19, 525-530. https://doi.org/10.1016/j.proche.2016.03.048
[5]
Zhou, P. and Gong, H. (2012) Phase Stability, Mechanical Property, and Electronic Structure of an Mg-Ca System. Journal of the Mechanical Behavior of Biomedical Materials, 8, 154-164. https://doi.org/10.1016/j.jmbbm.2011.12.001
[6]
Huan, Z., Leeflang, M., Zhou, J., Fratila-Apachitei, L. and Duszczyk, J. (2010) In vitro Degradation Behavior and Cytocompatibility of Mg-Zn-Zr Alloys. Journal of Materials Science: Materials in Medicine, 21, 2623-2635. https://doi.org/10.1007/s10856-010-4111-8
[7]
Boehlert, C. and Knittel, K. (2006) The Microstructure, Tensile Properties, and Creep Behavior of Mg-Zn Alloys Containing 0-4.4 wt% Zn. Materials Science and Engineering A, 417, 315-321. https://doi.org/10.1016/j.msea.2005.11.006
[8]
Alizadeh, R. and Mahmudi, R. (2010) Effect of Sb Additions on the Microstructural Stability and Mechanical Properties of Cast Mg-4Zn Alloy. Materials Science and Engineering A, 527, 5312-5317. https://doi.org/10.1016/j.msea.2010.05.029
[9]
Song, Y., Zhang, S., Li, J., Zhao, C. and Zhang, X. (2010) Electrodeposition of Ca-P Coatings on Biodegradable Mg Alloy: in vitro Biomineralization Behavior. ActaBiomaterialia, 6, 1736-1742. https://doi.org/10.1016/j.actbio.2009.12.020
[10]
Niu, J., Yuan, G., Liao, Y., Mao, L., Zhang, J., Wang, Y., et al. (2013) Enhanced Biocorrosion Resistance and Biocompatibility of Degradable Mg-Nd-Zn-Zr Alloy by Brushite Coating. Materials Science and Engineering C, 33, 4833-4841. https://doi.org/10.1016/j.msec.2013.08.008
[11]
Shadanbaz, S. and Dias, G.J. (2012) Calcium Phosphate Coatings on Magnesium Alloys for Biomedical Applications: A Review. Acta Biomaterialia, 8, 20-30.
[12]
Chen, Y., Mak, A.F., Li, J., Wang, M. and Shum, A.W. (2005) Formation of Apatite on Poly (α-Hydroxy Acid) in an Accelerated Biomimetic Process. Journal of Biomedical Materials Research Part B: Applied Biomaterials, 73, 68-76. https://doi.org/10.1002/jbm.b.30178
[13]
Gray-Munro, J.E., Seguin, C. and Strong, M. (2009) Influence of Surface Modification on the in Vitro Corrosion Rate of Magnesium Alloy AZ31. Journal of Biomedical Materials Research Part A, 91, 221-230. https://doi.org/10.1002/jbm.a.32205
[14]
Phani, A., Gammel, F. and Hack, T. (2006) Structural, Mechanical and Corrosion Resistance Properties of Al2O3-CeO2 Nanocomposites in Silica Matrix on Mg Alloys by a Sol-Gel Dip Coating Technique. Surface and Coatings Technology, 201, 3299-3306.
[15]
Mohammed, H.I., Carradò, A. and Abdel-Fattah, W.I. (2015) Noble Metals Role in Autocatalytic Phosphate Coatings on TAV Alloys. I. Ag Functionalization of Autocatalytic Phosphate Deposition on TAV Alloys. Surface and Coatings Technology, 282, 171-179.
[16]
Le, V.Q., Pourroy, G., Cochis, A., Rimondini, L., Abdel-Fattah, W.I., Mohammed, H.I., et al. (2014) Alternative Technique for Calcium Phosphate Coating on Titanium Alloy Implants. Biomatter, 4, e28534. https://doi.org/10.4161/biom.28534
[17]
Mohammed, H.I., Abdel-Fattah, W.I., Sallam, M.A., El-Sayed, M.E., Talaat, M.S., Faerber, J., et al. (2012) Calcium Phosphate Coating on Ti6Al4V by Autocatalytic Route. Bioinspired, Biomimetic and Nanobiomaterials, 1, 221-228. https://doi.org/10.1680/bbn.12.00012
[18]
Moussa, M.E., Waly, M.A. and El-Sheikh, A.M. (2013) Effect of High-Intensity Ultrasonic Treatment on Modification of Primary Mg2Si in the Hypereutectic Mg-Si Alloys. Journal of Alloys and Compounds, 577, 693-700.
[19]
Annual Book of ASTM Standards (2006) Metals-Mechanical Testing; Elevated and Low-Temperature Tests; Metallography. ASTM International, Vol. 3, Baltimore.
[20]
Kokubo, T. and Takadama, H. (2006) How Useful Is SBF in Predicting in Vivo Bone Bioactivity? Biomaterials, 27, 2907-2915.
[21]
Fan, J., Qiu, X., Niu, X., Tian, Z., Sun, W., Liu, X., et al. (2013) Microstructure, Mechanical Properties, in Vitro Degradation and Cytotoxicity Evaluations of Mg-1.5 Y-1.2 Zn-0.44 Zr Alloys for Biodegradable Metallic Implants. Materials Science and Engineering: C, 33, 2345-2352.
[22]
Jia, H., Feng, X. and Yang, Y. (2015) Influence of Solution Treatment on Microstructure, Mechanical and Corrosion Properties of Mg-4Zn Alloy. Journal of Magnesium and Alloys, 3, 247-252.
[23]
Razavi, M., Fathi, M. and Meratian, M. (2010) Fabrication and Characterization of Magnesium-Fluorapatite Nanocomposite for Biomedical Applications. Materials Characterization, 61, 1363-1370.
[24]
Bakhsheshi-Rad, H., Idris, M., Abdul-Kadir, M., Ourdjini, A., Medraj, M., Daroonparvar, M., et al. (2014) Mechanical and Bio-Corrosion Properties of Quaternary Mg-Ca-Mn-Zn Alloys Compared with Binary Mg-Ca Alloys. Materials & Design, 53, 283-292.
[25]
Liu, Z., Chen, Z., Liu, X. and Tao, J. (2006) Influence of Antimony Addition on Heat Resistance of AE41 Magnesium Alloy. Chinese Journal of Materials Research, 20, 186.
[26]
Guangyin, Y., Yangshan, S. and Wenjiang, D. (2000) Effects of Sb Addition on the Microstructure and Mechanical Properties of AZ91 Magnesium Alloy. Scripta Materialia, 43, 1009-1013.
[27]
Balasubramani, N., Srinivasan, A., Pillai, U.S., Raghukandan, K. and Pai, B. (2008) Effect of Antimony Addition on the Microstructure and Mechanical Properties of ZA84 Magnesium Alloy. Journal of Alloys and Compounds, 455, 168-173.
[28]
Nayyeri, G. and Mahmudi, R. (2010) Effects of Sb Additions on the Microstructure and Impression Creep Behavior of a Cast Mg-5Sn Alloy. Materials Science and Engineering: A, 527, 669-678.
[29]
Cong, M., Li, Z., Liu, J. and Li, S. (2014) Effect of Sr on Microstructure, Tensile Properties and Wear Behavior of As-Cast Mg-6Zn-4Si Alloy. Materials & Design, 53, 430-434.
[30]
Hall, E. (1970) Yield Point Phenomena in Metals and Alloys. Macmillan, London. https://doi.org/10.1007/978-1-4684-1860-6
[31]
Zhen, Z., Xi, T.-F. and Zheng, Y.-F. (2013) A Review on in Vitro Corrosion Performance Test of Biodegradable Metallic Materials. Transactions of Nonferrous Metals Society of China, 23, 2283-2293.
[32]
Song, G., Atrens, A., St John, D., Wu, X. and Nairn, J. (1997) The Anodic Dissolution of Magnesium in Chloride and Sulphate Solutions. Corrosion Science, 39, 1981-2004.
[33]
Feng, Q., Cui, F., Wang, H., Kim, T. and Kim, J. (2000) Influence of Solution Conditions on Deposition of Calcium Phosphate on Titanium by NaOH-Treatment. Journal of Crystal Growth, 210, 735-740.
[34]
Wen, C., Guan, S., Peng, L., Ren, C., Wang, X. and Hu, Z. (2009) Characterization and Degradation Behavior of AZ31 Alloy Surface Modified by Bone-Like Hydroxyapatite for Implant Applications. Applied Surface Science, 255, 6433-6438.
