Hypotheses:Values
of serum markers related to bone quality are abnormal in young female ballet
dancers. Methods: In 13
elite Japanese female ballet dancers (average age, 22 years), markers related
to bone quality were investigated. These included: serum homocystein (HC), a
marker of increased oxidative stress; pentosidine (Pent), a marker of
glycation- or oxidation-induced non-enzymatic cross-links; markers of bone
metabolism (bone alkaline phosphatase, BAP; tartrate-resistant acid phosphatase
5b, TRAP5b) and bone mineral density (BMD). It was determined whether there is
a relationship between bone quality markers’ levels are related to amenorrhea
and/or fatigue fractures. Results: Two dancers had fatigue fractures and
3 had a history of secondary amenorrhea. The average BMD was 1.305 ± 0.12 (g/cm2),
in all these cases the Z-score was higher than -1.0. Although the serum levels
of BAP, TRAP5b, and HC were normal in all examined dancers, in 2 out of 3
dancers with a history of secondary amenorrhea, pentosidine serum levels were
increased. No relationship between bone quality markers’ levels and fatigue
fractures was found. Conclusion:
Latent deterioration of bone quality may occur in female athletes with
secondary amenorrhea and otherwise normal BMD and calcium metabolism markers.
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