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Computation of the Genetic Code: Full Version

DOI: 10.4236/jcc.2017.510008, PP. 78-94

Keywords: Genetic Code, Overlapping Genes Uniform Overlap, Computation Code

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Abstract:

One of the problems in the development of mathematical theory of the genetic code (summary is presented in [1], the detailed—to [2]) is the problem of the calculation of the genetic code. Similar problem in the world is unknown and could be delivered only in the 21st century. One approach to solving this problem is devoted to this work. For the first time a detailed description of the method of calculation of the genetic code was provided, the idea of which was first published earlier [3]), and the choice of one of the most important sets for the calculation was based on an article [4]. Such a set of amino acid corresponds to a complete set of representation of the plurality of overlapping triple gene belonging to the same DNA strand. A separate issue was the initial point, triggering an iterative search process all codes submitted by the initial data. Mathematical analysis has shown that the said set contains some ambiguities, which have been founded because of our proposed compressed representation of the set. As a result, the developed method of calculation was reduced to two main stages of research, where at the first stage only single-valued domains were used in the calculations. The proposed approach made it possible to significantly reduce the amount of computation at each step in this complex discrete structure.

References

[1]  Kozlov, N.N. and Eneev, T.M. (2017) Fundamentals of a Mathematical Theory of Genetic Code. Doklady Mathematics, 95, 1-3.
[2]  Kozlov. N.N. (2014) Genetic Code: A Mathematician’s Point of View. Palamarium Academic, Hamburg, 336 p.
[3]  Kozlov, N.N. (2015) Method of Computing a Genetic Code. Doklady Mathematics, 91, 263-266.
[4]  Kozlov, N.N. (2015) On Overlaps of More than Two Genes: A Theorem for Homogeneous Overlaps. Doklady Mathematics, 91, 1-3.
[5]  Kozlov, N.N. (2002) A Theorem on the Genetic Code. Doklady Mathematics, 65, 83-87.
[6]  Kozlov, N.N. (2008) Sets Generated by Genetic Code. Doklady Mathematics, 78, 851-855.
[7]  Nakayama T., Asai, S., Takahashi Y., et al. (2007) Overlapping of Genes in the Human. International Journal of Biomedical Science, 3, 14-19.
[8]  Kozlov, N.N. (2010) Ambiguity in Sets Generated by the Genetic Code. Doklady Mathematics, 81, 364-367.
[9]  Kozlov, N.N. (2013) One Function of Ambiguities from the Sets Generated by the Genetic Code. Mathematical Models and Computer Simulations, 5, 17-24.
[10]  Kozlov N.N. (2015) Three Functions of Ambiguities Generated by the Genetic Code. Mathematical Models and Computer Simulations, 7, 401-408.
[11]  Kozlov, N.N. (2010) Computation of the Genetic Code. Doklady Mathematics, 82, 535-539.
[12]  Kozlov, N.N (2012) Computation of the Genetic Code. Mathematical Models and Computer Simulations, 4, 36-46.

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