Background: Spinal subdural empyema (SSE) is rare, with less than 70 case reports in
adults. The pathomechanism of infection and vulnerable patient populations have
yet to be delineated. Reported outcomes are varied. Case Description: Case report of an isolated spinal subdural empyema with no obvious source in a
65-year-old female presenting with an acute neurologic deficit requiring
emergent surgical intervention. A Pub Med search of keywords “Spinal Subdural
Empyema” and/or “Spinal Subdural Abscess” with review of all associated English
language literature was conducted. Pertinent data were compiled, analyzed, and
placed into chart and graph format. Conclusions: SSE is rare and often
progresses in 3 separate chronologic stages; pain/fever, neurologic deficit,
and paralysis. Tenderness to palpation is often absent. 3 methods of spread
have been postulated: hematogenous, contiguous, and iatrogenic. Staphylococcus aureus is the most common
infecting organism. The lumbar spine, followed closely by the thoracic spine,
is most commonly affected. Contrasted MRI is the preferred diagnostic modality.
Emergent surgical SSE evacuation followed by parenteral antibiotics is recommended,
as surgical outcomes are far superior to non-surgical management. The patient
featured in this case made a full neurologic recovery by 6-month follow-up.
References
[1]
Harris, L.F., et al. (1987) Subdural Empyema and Epidural Abscess: Recent Experience in a Community Hospital. Southern Medical Journal, 80, 1254-1258.
https://doi.org/10.1097/00007611-198710000-00014
[2]
Lownie, S.P. and Ferguson, G.G. (1989) Spinal Subdural Empyema Complicating Cervical Discography. Spine (Phila Pa 1976), 14, 1415-1417.
https://doi.org/10.1097/00007632-198912000-00023
[3]
Velissaris, D., et al. (2009) Spinal Subdural Staphylococcus Aureus Abscess: Case Report and Review of the Literature. World Journal of Emergency Surgery, 4, 31.
https://doi.org/10.1186/1749-7922-4-31
[4]
Usoltseva, N., et al. (2014) Spinal Subdural Abscess: A Rare Complication of Decubitus Ulcer. Clinical Medicine & Research, 12, 68-72.
[5]
Pompucci, A., et al. (2007) Cranio-Spinal Subdural Empyema Due to S. intermedius: A Case Report. Journal of Neuroimaging: Official Journal of the American Society of Neuroimaging, 17, 358-360.
[6]
Coumans, J.V. and Walcott, B.P. (2011) Rapidly Progressive Lumbar Subdural Empyema Following Acromial Bursal Injection. Journal of Clinical Neuroscience, 18, 1562-1563. https://doi.org/10.1016/j.jocn.2011.03.009
[7]
Heusner, A.P. (1948) Nontuberculous Spinal Epidural Infections. The New England Journal of Medicine, 239, 845-854. https://doi.org/10.1056/NEJM194812022392301
[8]
Lim, H.Y., et al. (2013) Chronic Spinal Subdural Abscess Mimicking an Intradural-Extramedullary Tumor. European Spine Journal, 22, 497-500.
https://doi.org/10.1007/s00586-013-2700-1
[9]
Fraser, R.A., et al. (1973) Spinal Subdural Empyema. Archives of Neurology, 28, 235-238. https://doi.org/10.1001/archneur.1973.00490220043005
[10]
Vural, M., et al. (2005) Spinal subdural Staphylococcus aureus Abscess: Case Report and Review of the Literature. Acta Neurologica Scandinavica, 112, 343-346.
https://doi.org/10.1111/j.1600-0404.2005.00496.x
[11]
Bartels, R.H., Jong, D. and Grotenhuis, J.A. (1992) Spinal Subdural Abscess. Case Report. Journal of Neurosurgery, 76, 307-311.
[12]
Chern, S.H., et al. (2009) Methicillin-Resistant Staphylococcus aureus Retropharyngeal Abscess Complicated by a Cervical Spinal Subdural Empyema. Journal of Clinical Neuroscience, 16, 144-146.
[13]
Heindel, C.C., Ferguson, J.P. and Kumarasamy, T. (1974) Spinal Subdural Empyema Complicating Pregnancy. Case Report. Journal of Neurosurgery, 40, 654-656.
https://doi.org/10.3171/jns.1974.40.5.0654
[14]
De Bonis, P., et al. (2009) Cranial and Spinal Subdural Empyema. British Journal of Neurosurgery, 23, 335-340. https://doi.org/10.1080/02688690902939902
[15]
Dacey, R.G., et al. (1978) Spinal Subdural Empyema: Report of Two Cases. Neurosurgery, 3, 400-403.
[16]
Harries-Jones, R., et al. (1990) Meningitis and Spinal Subdural Empyema as a Complication of Sinusitis. Journal of Neurology, Neurosurgery, and Psychiatry, 53, 441.
[17]
Babu, R., et al. (1992) Intramedullary Abscess Associated with a Spinal Cord Ependymoma. Neurosurgery, 30, 121-123.
[18]
Baker, R.P., Brown, E.M. and Coakham, H.B. (2003) Overwhelming Cranial and Spinal Subdural Empyema Secondary Infected Sacral Decubitus Ulcers. British Journal of Neurosurgery, 17, 572-573.
https://doi.org/10.1080/02688690310001626886
[19]
Chen, C.Y., et al. (1999) Dermoid Cyst with Dermal Sinus Tract Complicated with Spinal Subdural Abscess. Pediatric Neurology, 20, 157-160.
[20]
Wu, A.S., et al. (2004) Spinal Subdural Empyema after a Dural Tear. Case Report. Neurosurgical Focus, 17, E10. https://doi.org/10.3171/foc.2004.17.6.10
[21]
Hos, N.J., et al. (2014) Autoinfection as a Cause of Postpartum Subdural Empyema Due to Mycoplasma hominis. Infection, 43, 241-244.
[22]
Kraeutler, M.J., et al. (2014) Spinal Subdural Abscess Following Epidural Steroid Injection. Journal of Neurosurgery Spine, 22, 90-93.
[23]
Hershkowitz, S., et al. (1990) Spinal Empyema in Crohn’s Disease. Journal of Clinical Gastroenterology, 12, 67-69. https://doi.org/10.1097/00004836-199002000-00017
[24]
Alvarez Sastre, C., et al. (2002) Subdural Empyema with Extension to Vertebral Canal Secondary to Salmonellosis in a Patient with Systemic Lupus Erythematosus. Child’s Nervous System, 18, 528-531. https://doi.org/10.1007/s00381-002-0618-8
[25]
Alessi, G., Lemmerling, M. and Nathoo, N. (2003) Combined Spinal Subdural Tuberculous Empyema and Intramedullary Tuberculoma in an HIV-Positive Patient. European Radiology, 13, 1899-1901. https://doi.org/10.1007/s00330-002-1678-6
[26]
Levy, M.L., et al. (1993) Subdural Empyema of the Cervical Spine: Clinicopathological Correlates and Magnetic Resonance Imaging. Report of Three Cases. Journal of Neurosurgery, 79, 929-935. https://doi.org/10.3171/jns.1993.79.6.0929
[27]
Greenlee, J.E. (2003) Subdural Empyema. Current Treatment Options in Neurology, 5, 13-22. https://doi.org/10.1007/s11940-003-0019-7
[28]
Khalil, J.G., et al. (2013) Thoracolumbosacral Spinal Subdural Abscess: Magnetic Resonance Imaging Appearance and Limited Surgical Management. Spine, 38, E844-E847. https://doi.org/10.1097/brs.0b013e31828d5f30
[29]
Sathi, S., et al. (1994) Spinal Subdural Abscess: Successful Treatment with Limited Drainage and Antibiotics in a Patient with AIDS. Surgical Neurology, 42, 424-427.
[30]
Price, D.B., et al. (1993) Spinal Subdural Empyema: Appearance on Intraoperative Sonography. Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine, 12, 493-495.