Vertebral osteomyelitis (VOM) and spinal epidural
abscesses (SEA) are rare infections on the spinal column, more prominently seen
in intravenous drug users, diabetics and the immunosuppressed. We report an
extremely rare case of a patient with a chronic history of lumbar post-surgical cutaneo-spinal fistulous infection that was
unresponsive to conventional antibiotic therapy and ultimately required surgical debridement and spinal re-instrumentation.
The novelty of this case was the chronic nature of the patient’s condition that
was made possible only by a fortunate post-surgical cutaneo-spinal
fistula that withdrew infected particles away from the neurological structures
and thus prevented imminent compressive and neurological deficits, and possibleeventual
death. This rare case highlights the need for prompt surgical evaluation and
intervention in patients with progressive VOM or SEA with associatedcutaneo-spinal fistulas, especially in cases where
conventional antibiotic treatments have failed. We highly recommend a low threshold
for surgical debridement and hardware removal with re-instrumentation as
appropriate before a spinal compressive emergency arises and/or sepsis
develops.
References
[1]
Cheung, W.Y. and Luk, K.D. (2012) Pyogenic Spondylitis. International Orthopaedics, 36, 397-404. https://doi.org/10.1007/s00264-011-1384-6
[2]
Reihsaus, E., Waldbaur, H. and Seeling, W. (2000) Spinal Epidural Abscess: A Meta-Analysis of 915 Patients. Neurosurgical Review, 23, 175-204.
https://doi.org/10.1007/PL00011954
[3]
Darouiche, R.O. (2006) Spinal Epidural Abscess. The New England Journal of Medicine, 355, 2012-2020. https://doi.org/10.1056/NEJMra055111
[4]
Ziu, M., Dengler, B., Cordell, D. and Bartanusz, V. (2014) Diagnosis and Management of Primary Pyogenic Spinal Infections in Intravenous Recreational Drug Users. Neurosurgical Focus, 37, E3. https://doi.org/10.3171/2014.6.FOCUS14148
[5]
Butler, J.S., Shelly, M.J., Timlin, M., Powderly, W.G. and O’byrne, J.M. (2006) Nontuberculous Pyogenic Spinal Infection in Adults: A 12-Year Experience from a Tertiary Referral Center. Spine, 31, 2695-2700.
https://doi.org/10.1097/01.brs.0000244662.78725.37
[6]
Arko, L., Quach, E., Nguyen, V., Chang, D., Sukul, V. and Kim, B.S. (2014) Medical and Surgical Management of Spinal Epidural Abscess: A Systematic Review. Neurosurgical Focus, 37, E4. https://doi.org/10.3171/2014.6.FOCUS14127
[7]
Nolla, J.M., Ariza, J., Gómez-Vaquero, C., et al. (2002) Spontaneous Pyogenic Vertebral Osteomyelitis in Nondrug Users. Seminars in Arthritis & Rheumatism, 31, 271-278. https://doi.org/10.1053/sarh.2002.29492
[8]
Shweikeh, F., Saeed, K., Bukavina, L., Zyck, S., Drazin, D. and Steinmetz, M.P. (2014) An Institutional Series and Contemporary Review of Bacterial Spinal Epidural Abscess: Current Status and Future Directions. Neurosurgical Focus, 37, E9.
https://doi.org/10.3171/2014.6.FOCUS14146
[9]
Zimmerer, S.M., Conen, A., Müller, A.A., et al. (2011) Spinal Epidural Abscess: Aetiology, Predisponent Factors and Clinical Outcomes in a 4-Year Prospective Study. European Spine Journal, 20, 2228-2234. https://doi.org/10.1007/s00586-011-1838-y
[10]
Chan, C.T. and Gold, W.L. (1998) Intramedullary Abscess of the Spinal Cord in the Antibiotic Era: Clinical Features, Microbial Etiologies, Trends in Pathogenesis, and Outcomes. Clinical Infectious Diseases, 27, 619-626. https://doi.org/10.1086/514699
[11]
Tuchman, A., Pham, M. and Hsieh, P.C. (2014) The Indications and Timing for Operative Management of Spinal Epidural Abscess: Literature Review and Treatment Algorithm. Neurosurgical Focus, 37, E8.
https://doi.org/10.3171/2014.6.FOCUS14261
[12]
O’daly, B.J., Morris, S.F. and O’rourke, S.K. (2008) Long-Term Functional Outcome in Pyogenic Spinal Infection. Spine, 33, E246-E253.
https://doi.org/10.1097/BRS.0b013e31816b8872
[13]
Viola, R.W., King, H.A., Adler, S.M. and Wilson, C.B. (1997) Delayed Infection after Elective Spinal Instrumentation and Fusion. A Retrospective Analysis of Eight Cases. Spine, 22, 2444-2450. https://doi.org/10.1097/00007632-199710150-00023
[14]
Etemadrezaei, H., Zabihyan, S., Shakeri, A. and Ganjeifar, B. (2015) 17-Year-Delayed Fistula Formation after Elective Spinal Instrumentation: A Case Report. Iranian Red Crescent Medical Journal, 17, e28090.
https://doi.org/10.5812/ircmj.17(5)2015.28090
[15]
Tilkeridis, K., Touzopoulos, P., Ververidis, A., Christodoulou, S., Kazakos, K. and Drosos, G.I. (2014) Use of Demineralized Bone Matrix in Spinal Fusion. World Journal of Orthopedics, 5, 30-37. https://doi.org/10.5312/wjo.v5.i1.30
[16]
Robinson, Y., Tschoeke, S.K., Kayser, R., Boehm, H. and Heyde, C.E. (2009) Reconstruction of Large Defects in Vertebral Osteomyelitis with Expandable Titanium Cages. International Orthopaedics, 33, 745-749.
https://doi.org/10.1007/s00264-008-0567-2