This study
aims to determine the retention time of iodinated contrast agents (ICA) in the coronary
artery. The mechanical aspect of ICA displacement was studied in order to better
understand the effect of these products on the inner wall of the artery of patients
with coronary artery stenosis, undergoing repeated imaging examinations with iodinated
contrast agents. ICA flow, ICA and blood flow in the artery were modelled. The fluid
was regarded to be viscous, incompressible and Newtonian. Blood flow was presumed
to be unidirectional, laminar and unstationary. Iodine flow velocity and retention
time were calculated using the Runge-Kutta 4th order method programmed in C++ and
MatLab R2013a language. The results showed that for coronary artery CT-scans, ICA
retention time is 1 minute 40 seconds and for coronary arteriography it is between
2.41 and 3.61 seconds. The values calculated were compared to theoretical values
and to clinical observations. The results enabled us to validate our model.
References
[1]
Lanzer, P. and Lipton, M. (1997) Diagnostics of Vascular Diseases Principles and Technology. Springer, New York.
[2]
Solacroup, Boyer, Le Marec, Schouman Claeys, (2001) Bases Physiques des rayons X: Produits de contraste en radiologie, CERF.
[3]
Joubert, A., Biston, M.C. and Boudou, C. (2005) Irradiation in Presence of Iodinated Contrast Agent Results in Radiosensitization of Endothelial Cells: Consequences for Computed Tomography Therapy. International Journal of Radiation Oncology * Biology * Physics, 62, 1486-1496.
[4]
Hocine, N., Meignan, M. and Masset, H. Monte Carlo Simulations Used to Calculate the Energy Deposited in the Coronary Artery Lumen as a Function of Iodine Concentration and Photon Energy. (In Press)
[5]
Quemada, D. (1976) Hydrodynamique sanguineHémorhéologie et écoulement du sang dans les petits vaisseaux. Journal de Physique, 37, 9-22.
[6]
Mestel, J. (2009) Bio Fluid Mechanics: Pulsatile flow in a long straight artery. Imperial College, London.
Ku, D.N. (1997) Blood Flow in Arteries. The Annual Review of Fluid Mechanics, 29, 399-434. https://doi.org/10.1146/annurev.fluid.29.1.399
[9]
Herrmann, J., Kaski, J.C. and Lerman, A. (2012) Coronary Microvascular Dysfunction in the Clinical Setting: From Mystery to Reality. European Heart Journal, 33, 2771-2781. https://doi.org/10.1093/eurheartj/ehs246
[10]
Wei, L. (2004) Numerical Study of Steady and Pulsatile Flow through Stenosed Tubes. PhD Thesis, Department of Mechanical Engineering, National University of Singapore, Singapore.
