品行障碍脑影像学研究现状与展望
The Present Status and Prospect of Brain Imaging in Conduct Disorder

DOI: 10.12677/AP.2016.69126, PP. 981-989

Keywords: 品行障碍，结构性核磁共振成像，弥散张量成像，事件相关电位
Conduct Disorder (CD), Structural Magnetic Resonance Imaging (sMRI), Diffusion Tensor Imaging (DTI), Event-Related Potentials (ERPs)

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Abstract:

品行障碍(conduct disorder, CD)是儿童青少年期最常见的一种精神障碍之一。本文主要对CD的结构性核磁共振成像和弥散张量成像研究进行综述和分析，并在此基础指出了未来CD脑成像研究可能的发展方向，以期为进一步研究CD的特征性脑影像学标记提供帮助和指导。
Conduct disorder (CD) is one of the most common psychogeny in children and adolescents. In this review, we mainly focused on the studies about structural magnetic resonance imaging (sMRI) and diffusion tensor imaging (DTI) in conduct disorder, and we also suggested the possible directions of development in these fields. We hoped that this review would give help and guidance to further studies on the brain imaging markers of CD.

References

[1]	American Psychiatric Association (2013). Diagnostic and Statistical Manual of Mental Disorders (15th ed.). Arlington, VA: American Psychiatric Publishing.
[2]	Aoki, Y., Inokuchi, R., Nakao, T., & Yamasue, H. (2014). Neural Bases of Anti-social Behavior: A Voxel-Based Meta-Analysis. Social Cognitive and Affective Neuroscience, 9, 1223-1231. http://dx.doi.org/10.1093/scan/nst104
[3]	Berkout, O. V., Young, J. N., & Gross, A. M. (2011). Mean Girls and Bad Boys: Recent Research on Gender Differences in Conduct Disorder. Aggression and Violent Behavior, 16, 503-511. http://dx.doi.org/10.1016/j.avb.2011.06.001
[4]	Bertoletti, E., Michelini, G., Moruzzi, S., Ferrer, G., Ferini-Strambi, L., Stazi, M. A., Ogliari, A., & Battaglia, M. (2014). A General Population Twin Study of Conduct Problems and the Au-ditory P300 Waveform. Journal of Abnormal Child Psychology, 42, 861-869. http://dx.doi.org/10.1007/s10802-013-9836-7
[5]	Blair, R. J., Leibenluft, E., & Pine, D. S. (2014). Conduct Disorder and Callous-Unemotional Traits in Youth. The New England Journal of Medicine, 371, 2207-2216. http://dx.doi.org/10.1056/NEJMra1315612
[6]	Boes, A. D., Tranel, D., Anderson, S. W., & Nopoulos, P. (2008). Right Anterior Cingulate: A Neuroanatomical Correlate of Aggression and Defiance in Boys. Behavioral Neuroscience, 122, 677-684. http://dx.doi.org/10.1037/0735-7044.122.3.677
[7]	Brazil, I. A., Verkes, R. J., Brouns, B. H., Buitelaar, J. K., Bulten, B. H., & de Bruijn, E. R. (2012). Differentiating Psychopathy from General Antisociality Using the P3 as a Psycho-physiological Correlate of Attentional Allocation. PLoS One, 7, e50339. http://dx.doi.org/10.1371/journal.pone.0050339
[8]	Cappadocia, M. C., Desrocher, M., Pepler, D., & Schroeder, J. H. (2009). Contextualizing the Neurobiology of Conduct Disorder in an Emotion Dysregulation Framework. Clinical Psychology Review, 29, 506-518. http://dx.doi.org/10.1016/j.cpr.2009.06.001
[9]	Craig, M. C., Catani, M., Deeley, Q., Latham, R., Daly, E., Kanaan, R., Picchioni, M., McGuire, P. K., Fahy, T., & Murphy, D. G. (2009). Altered Connections on the Road to Psychopathy. Molecular Psychiatry, 14, 946-953, 907.
[10]	Dalwani, M., Sakai, J. T., Mikulich-Gilbertson, S. K., Tanabe, J., Raymond, K., McWilliams, S. K., Thompson, L. L., Banich, M. T., & Crowley, T. J. (2011). Reduced Cortical Gray Matter Volume in Male Adolescents with Substance and Conduct Problems. Drug and Alcohol Dependence, 118, 295-305. http://dx.doi.org/10.1016/j.drugalcdep.2011.04.006
[11]	Davidson, R. J., Putnam, K. M., & Larson, C. L. (2000). Dysfunction in the Neural Circuitry of Emotion Regulation—A Possible Prelude to Violence. Science, 289, 591-594. http://dx.doi.org/10.1126/science.289.5479.591
[12]	Fahim, C., He, Y., Yoon, U., Chen, J., Evans, A., & Perusse, D. (2011). Neuroanatomy of Childhood Disruptive Behavior Disorders. Aggressive Behavior, 37, 326-337. http://dx.doi.org/10.1002/ab.20396
[13]	Fairchild, G., Hagan, C. C., Walsh, N. D., Passamonti, L., Calder, A. J., & Goodyer, I. M. (2013). Brain Structure Abnormalities in Adolescent Girls with Conduct Disorder. Journal of Child Psy-chology and Psychiatry, 54, 86-95. http://dx.doi.org/10.1111/j.1469-7610.2012.02617.x
[14]	Fairchild, G., Passamonti, L., Hurford, G., Hagan, C. C., von dem Hagen, E. A., van Goozen, S. H., Goodyer, I. M., & Calder, A. J. (2011). Brain Structure Abnormalities in Ear-ly-Onset and Adolescent-Onset Conduct Disorder. American Journal of Psychiatry, 168, 624-633. http://dx.doi.org/10.1176/appi.ajp.2010.10081184
[15]	Finger, E. C., Marsh, A., Blair, K. S., Majestic, C., Evangelou, I., Gupta, K., Schneider, M. R., Sims, C., Pope, K., Fowler, K., Sinclair, S., Tovar-Moll, F., Pine, D., & Blair, R. J. (2012). Impaired Functional But Preserved Structural Connectivity in Limbic White Matter Tracts in Youth with Conduct Disorder or Oppositional Defiant Disorder plus Psychopathic Traits. Psychiatry Research, 202, 239-244. http://dx.doi.org/10.1016/j.pscychresns.2011.11.002
[16]	Frick, P. J., Ray, J. V., Thornton, L. C., & Kahn, R. E. (2014). Annual Research Review: A Developmental Psychopathology Approach to Understanding Callous-Unemotional Traits in Children and Adolescents with Serious Conduct Problems. Journal of Child Psychology and Psychiatry, 55, 532-548. http://dx.doi.org/10.1111/jcpp.12152
[17]	Gao, Y., & Raine, A. (2009). P3 Event-Related Potential Im-pairments in Antisocial and Psychopathic Individuals: A Meta-Analysis. Biological Psychology, 82, 199-210. http://dx.doi.org/10.1016/j.biopsycho.2009.06.006
[18]	Gao, Y., Chen, H., Jia, H., Ming, Q., Yi, J., & Yao, S. (2016). Dysfunctional Feedback Processing in Adolescent Males with Conduct Disorder. International Journal of Psychophysiology, 99, 1-9. http://dx.doi.org/10.1016/j.ijpsycho.2015.11.015
[19]	Gilmore, C. S., Malone, S. M., & Iacono, W. G. (2012). Is the P3 Amplitude Reduction Seen in Externalizing Psychopathology Attributable to Stimulus Sequence Effects? Psychophysiology, 49, 248-251. http://dx.doi.org/10.1111/j.1469-8986.2011.01299.x
[20]	Haney-Caron, E., Caprihan, A., & Stevens, M. C. (2014). DTI-Measured White Matter Abnormalities in Adolescents with Conduct Disorder. Journal of Psychiatric Research, 48, 111-120. http://dx.doi.org/10.1016/j.jpsychires.2013.09.015
[21]	Hoppenbrouwers, S. S., Nazeri, A., de Jesus, D. R., Stirpe, T., Felsky, D., Schutter, D. J., Daskalakis, Z. J., & Voineskos, A. N. (2013). White Matter Deficits in Psychopathic Offenders and Correlation with Factor Structure. PLoS ONE, 8, e72375. http://dx.doi.org/10.1371/journal.pone.0072375
[22]	Huebner, T., Vloet, T. D., Marx, I., Konrad, K., Fink, G. R., Herpertz, S. C., & Herpertz-Dahlmann, B. (2008). Morphometric Brain Abnormalities in Boys with Conduct Disorder. Journal of the American Academy of Child & Adolescent, 47, 540-547. http://dx.doi.org/10.1097/CHI.0b013e3181676545
[23]	Hung, A. Y., Ahveninen, J., & Cheng, Y. (2013). Atypical Mismatch Negativity to Distressful Voices Associated with Conduct Disorder Symptoms. Journal of Child Psychology and Psychiatry, 54, 1016-1027. http://dx.doi.org/10.1111/jcpp.12076
[24]	Hyatt, C. J., Haney-Caron, E., & Stevens, M. C. (2012). Cortical Thickness and Folding Deficits in Conduct-Disordered Adolescents. Biological Psychiatry, 72, 207-214. http://dx.doi.org/10.1016/j.biopsych.2011.11.017
[25]	Hyde, L. W., Shaw, D. S., & Hariri, A. R. (2013). Under-standing Youth Antisocial Behavior Using Neuroscience through a Developmental Psychopathology Lens: Review, Inte-gration, and Directions for Research. Developmental Review, 33, 168- 223. http://dx.doi.org/10.1016/j.dr.2013.06.001
[26]	Jiang, Y., Guo, X., Zhang, J., Gao, J., Wang, X., Situ, W., Yi, J., Zhang, X., Zhu, X., Yao, S., & Huang, B. (2015). Abnormalities of Cortical Structures in Adolescent-Onset Conduct Dis-order. Psychological Medicine, 45, 3467-3479. http://dx.doi.org/10.1017/S0033291715001361
[27]	Kruesi, M. J., Casanova, M. F., Mannheim, G., & Johnson-Bilder, A. (2004). Reduced Temporal Lobe Volume in Early Onset Conduct Disorder. Psychiatry Research, 132, 1-11. http://dx.doi.org/10.1016/j.pscychresns.2004.07.002
[28]	Li, T. Q., Mathews, V. P., Wang, Y., Dunn, D., & Kro-nenberger, W. (2005). Adolescents with Disruptive Behavior Disorder Investigated Using an Optimized MR Diffusion Tensor Imaging Protocol. Annals of the New York Academy of Sciences, 1064, 184-192. http://dx.doi.org/10.1196/annals.1340.034
[29]	Lindner, P., Savic, I., Sitnikov, R., Budhiraja, M., Liu, Y., Jokinen, J., Tiihonen, J., & Hodgins, S. (2016). Conduct Disorder in Females Is Associated with Reduced Corpus Callosum Structural Integrity Independent of Comorbid Disorders and Exposure to Maltreatment. Translational Psychiatry, 6, e714. http://dx.doi.org/10.1038/tp.2015.216
[30]	Motzkin, J. C., Newman, J. P., Kiehl, K. A., & Koenigs, M. (2011). Re-duced Prefrontal Connectivity in Psychopathy. The Journal of Neuroscience, 31, 17348-17357. http://dx.doi.org/10.1523/JNEUROSCI.4215-11.2011
[31]	Olvera, R., Glahn, D., O’Donnell, L., Bearden, C., Soares, J., Winkler, A., & Pliszka, S. (2014). Cortical Volume Alterations in Conduct Disordered Adolescents with and without Bipolar Disorder. Journal of Clinical Medicine, 3, 416-431. http://dx.doi.org/10.3390/jcm3020416
[32]	Passamonti, L., Fairchild, G., Fornito, A., Goodyer, I. M., Nimmo-Smith, I., Hagan, C. C., & Calder, A. J. (2012). Abnormal Anatomical Connectivity between the Amygdala and Orbitofrontal Cortex in Conduct Disorder. PLoS ONE, 7, e48789. http://dx.doi.org/10.1371/journal.pone.0048789
[33]	Passamonti, L., Fairchild, G., Goodyer, I. M., Hurford, G., Ha-gan, C. C., Rowe, J. B., & Calder, A. J. (2010). Neural Abnormalities in Early-Onset and Adolescence-Onset Conduct Disorder. Archives of General Psychiatry, 67, 729-738. http://dx.doi.org/10.1001/archgenpsychiatry.2010.75
[34]	Raine, A., Lencz, T., Taylor, K., Hellige, J. B., Bihrle, S., Lacasse, L., Lee, M., Ishikawa, S., & Colletti, P. (2003). Corpus Callosum Abnormalities in Psychopathic Antisocial Indi-viduals. Archives of General Psychiatry, 60, 1134-1142. http://dx.doi.org/10.1001/archpsyc.60.11.1134
[35]	Rogers, J. C., & De Brito, S. A. (2016). Cortical and Subcortical Gray Matter Volume in Youths with Conduct Problems: A Meta-Analysis. Jama Psychiatry, 73, 64-72. http://dx.doi.org/10.1001/jamapsychiatry.2015.2423
[36]	Rubia, K. (2011). “Cool” Inferior Frontostriatal Dysfunction in Attention-Deficit/Hyperactivity Disorder versus “Hot” Ventromedial Orbitofrontal-Limbic Dysfunction in Conduct Disorder: A Review. Biological Psychiatry, 69, e69-e87. http://dx.doi.org/10.1016/j.biopsych.2010.09.023
[37]	Ruigrok, A. N., Salimi-Khorshidi, G., Lai, M. C., Baron-Cohen, S., Lombardo, M. V., Tait, R. J., & Suckling, J. (2014). A Meta-Analysis of Sex Differences in Human Brain Structure. Neuroscience and Biobehavioral Reviews, 39, 34-50. http://dx.doi.org/10.1016/j.neubiorev.2013.12.004
[38]	Sarkar, S., Craig, M. C., Catani, M., Dell’acqua, F., Fahy, T., Deeley, Q., & Murphy, D. G. (2013). Frontotemporal White-Matter Microstructural Abnormalities in Adolescents with Conduct Disorder: A Diffusion Tensor Imaging Study. Psychological Medicine, 43, 401-411. http://dx.doi.org/10.1017/S003329171200116X
[39]	Sarkar, S., Daly, E., Feng, Y., Ecker, C., Craig, M. C., Harding, D., Deeley, Q., & Murphy, D. G. (2014). Reduced Cortical Surface Area in Adolescents with Conduct Disorder. European Child & Adolescent Psychiatry, 24, 909-917. http://dx.doi.org/10.1007/s00787-014-0639-3
[40]	Sarkar, S., Dell’Acqua, F., Froudist Walsh, S., Blackwood, N., Scott, S., Craig, M. C., Deeley, Q., & Murphy, D. G. (2016). A Whole-Brain Investigation of White Matter Microstructure in Adolescents with Conduct Disorder. PLoS ONE, 11, e0155475. http://dx.doi.org/10.1371/journal.pone.0155475
[41]	Sterzer, P., Stadler, C., Poustka, F., & Kleinschmidt, A. (2007). A Structural Neural Deficit in Adolescents with Conduct Disorder and Its Association with Lack of Empathy. Neuroimage, 37, 335-342. http://dx.doi.org/10.1016/j.neuroimage.2007.04.043
[42]	Stevens, M. C., & Haney-Caron, E. (2012). Comparison of Brain Volume Abnormalities between ADHD and Conduct Disorder in Adolescence. Journal of Psychiatry & Neuroscience, 37, 389-398. http://dx.doi.org/10.1503/jpn.110148
[43]	Sundram, F., Deeley, Q., Sarkar, S., Daly, E., Latham, R., Craig, M., Raczek, M., Fahy, T., Picchioni, M., Barker, G. J., & Murphy, D. G. (2012). White Matter Microstructural Abnormalities in the Frontal Lobe of Adults with Antisocial Personality Disorder. Cortex, 48, 216-229. http://dx.doi.org/10.1016/j.cortex.2011.06.005
[44]	Wallace, G. L., White, S. F., Robustelli, B., Sinclair, S., Hwang, S., Martin, A., & Blair, R. J. (2014). Cortical and Subcortical Abnormalities in Youths with Conduct Disorder and Elevated Callous-Unemotional Traits. Journal of the American Academy of Child & Adolescent, 53, 456-465e1. http://dx.doi.org/10.1016/j.jaac.2013.12.008
[45]	Wang, Y., Horst, K. K., Kronenberger, W. G., Hummer, T. A., Mosier, K. M., Kalnin, A. J., Dunn, D. W., & Mathews, V. P. (2012). White Matter Abnormalities Associated with Dis-ruptive Behavior Disorder in Adolescents with and without Attention-Deficit/Hyperactivity Disorder. Psychiatry Research, 202, 245-251. http://dx.doi.org/10.1016/j.pscychresns.2012.01.005
[46]	Yang, Y., & Raine, A. (2009). Prefrontal Structural and Functional Brain Imaging Findings in Antisocial, Violent, and Psychopathic Individuals: A Meta-Analysis. Psychiatry Research, 174, 81-88. http://dx.doi.org/10.1016/j.pscychresns.2009.03.012
[47]	Zhang, J., Gao, J., Shi, H., Huang, B., Wang, X., Situ, W., Cai, W., Yi, J., Zhu, X., & Yao, S. (2014). Sex Differences of Uncinate Fasciculus Structural Connectivity in Individuals with Conduct Disorder. Biomed Research International, 2014, Article ID: 673165. http://dx.doi.org/10.1155/2014/673165
[48]	Zhang, J., Li, B., Gao, J., Shi, H., Wang, X., Jiang, Y., Ming, Q., Gao, Y., Ma, R., & Yao, S. (2015). Impaired Frontal-Basal Ganglia Connectivity in Male Adolescents with Conduct Disorder. PLoS ONE, 10, e0145011. http://dx.doi.org/10.1371/journal.pone.0145011
[49]	Zhang, J., Zhu, X., Wang, X., Gao, J., Shi, H., Huang, B., Situ, W., Yi, J., Zhu, X., & Yao, S. (2014). Increased Structural Connectivity in Corpus Callosum in Adolescent Males with Conduct Disorder. Journal of the American Academy of Child & Adolescent Psychiatry, 53, 466-475. http://dx.doi.org/10.1016/j.jaac.2013.12.015
[50]	Zuo, X. N., & Xing, X. X. (2014). Test-Retest Reliabilities of Resting-State FMRI Measurements in Human Brain Functional Connectomics: A Systems Neuroscience Perspective. Neuroscience and Biobehavioral Reviews, 45, 100-118. http://dx.doi.org/10.1016/j.neubiorev.2014.05.009

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