2,2',4,4'-四溴联苯醚毒性效应及其致毒机理
Toxic Effects and Mechanism of 2,2',4,4'-Tetrabromodiphenyl Ether

DOI: 10.12677/OJFR.2016.33006, PP. 34-41

Keywords: BDE-47，生殖发育毒性，甲状腺毒性，神经毒性，免疫毒性，致毒机理
BDE-47, Reproductive and Developmental Toxicity, Hyroid Toxicity, Neurotoxicity, Immune Toxicity, Toxic Mechanism

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Abstract:

2,2',4,4'-四溴联苯醚(tetrabromodiphenyl ether, BDE-47)是环境介质中含量最高的多溴联苯醚(PBDEs)同系物之一，具有亲脂性和生物易累积等特点，即使是较低浓度的胁迫，也会对生物体产生生理毒性。文章介绍了BDE-47在环境介质中的主要来源和分布，从生殖发育毒性、甲状腺毒性、神经毒性，免疫毒性等几个方面，阐述了BDE-47毒性效应及其致毒机理。
2,2',4,4'-tetrabromodiphenyl ether is one of the highest homologue of PBDEs in environmental media. It has lipophilic and bioaccumulation characteristics and can also produce physiological toxicity to organism even at low concentration. The paper introduces the main source and distri-bution in environment of BDE-47. The toxicity effects and mechanism of BDE-47 are illustrated from several aspects toxicity of reproductive, developmental, thyroid, neurotoxicity and immune.

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