Background: Diabetes is a risk factor for depression, but little is known about anxiety and other psychiatric disorders and quality of life. The aim of this study was to assess the prevalence of depression, anxiety in diabetic patients in our locality and to assess the quality of life in type 2 DM. Subjects & Methods: This study was a cross-sectional study and was carried out in outpatient clinics of specialized medical hospital, Mansoura university for a period of one year. From 217 diabetes mellitus subjects, only 202 patients were matched with 247 healthy people as a control group. All subjects were examined by using socioeconomic data, clinical data, and anthropometric examinations to assess body mass index and waist circumference. All patients were interviewed by using the Mini-International Neuropsychiatric Interview (MINI) version 5, MINI, Hospital Anxiety and Depression scale (HAD) and health-related quality of life (HRQOL) scales. Laboratory investigation in the form of fasting and two-hour postprandial blood sugar (FBS & 2hpp) and HbA1C levels were done. Results: 18.3% were found to be major depressive disorder; and 2.5% panic disorder, 1% other phobia. Generalized anxiety disorder and obsessive-compulsive disorder were found in one patient, no patients were found to be diagnosed as Bipolar disorder, schizophrenia, or substance abuse. Although there was no statistically significant difference between subjects and control groups regarding height, there was statistically significant difference between weights, BMI, with more scores among DM group. Moreover our study showed that HbA1c, fasting blood sugar, two hours post prandial blood sugar were more among DM patients and control groups. Anxiety, depression, and poorer quality of life were found to be more prevalent among DM patients than control groups. Conclusion: DM is associated with depression anxiety disorder with poorer quality of life.
References
[1]
Young, E.E. and Unachukwu, C.N. (2012) Psychosocial Aspects of Diabetes Mellitus. African Journal of Diabetes Medicine, 20, 5-7.
[2]
Anderson, F., Schade, R., Suissa, S. and Garbe, E. (2009) Long-Term Use of Antidepressants for Depressive Disorders and the Risk of Diabetes Mellitus. The American Journal of Psychiatry, 166, 591-598. https://doi.org/10.1176/appi.ajp.2008.08071065
[3]
Rubin, R.R. and Peyrot, M. (1992) Psychosocial Problems and Interventions in Diabetes: A Review of the Literature. Diabetes Care, 15, 1640-1657. https://doi.org/10.2337/diacare.15.11.1640
[4]
Huang, C.J., Chiu, H.C., Lee, M.H. and Wang, S.Y. (2011) Prevalence and Incidence of Anxiety Disorders in Diabetic Patients: A National Population-Based Cohort Study. General Hospital Psychiatry, 33, 8-15. https://doi.org/10.1016/j.genhosppsych.2010.10.008
[5]
Engum, A. (2007) The Role of Depression and Anxiety in Onset of Diabetes in a Large Population-Based Study. Journal of Psychosomatic Research, 62, 31-38. https://doi.org/10.1016/j.jpsychores.2006.07.009
[6]
Hermanns, N., Kulzer, B., Krichbaum, M., Kubiak, T. and Haak, T. (2005) Affective and Anxiety Disorders in a German Sample of Diabetic Patients: Prevalence, Co Morbidity and Risk Factors. Diabetic Medicine, 22, 293-300. https://doi.org/10.1111/j.1464-5491.2005.01414.x
[7]
Bani-Issa, W. (2011) Evaluation of the Health-Related Quality of Life of Emirati People with Diabetes: Integration of Sociodemographic and Disease-Related Variables. Eastern Mediterranean Health Journal, 17, 825-830.
[8]
Ribu, L., Hanestad, B.R., Moum, T., Birkeland, K. and Rustoen, T. (2007) Health-Related Quality of Life among Patients with Diabetes and Foot Ulcers: Association with Demographic and Clinical Characteristics. Journal of Diabetes and Its Complications, 21, 227-236. https://doi.org/10.1016/j.jdiacomp.2007.02.001
[9]
Peyrot, M., Rubin, R.R., Lauritzen, T., Snoek, F.J., Matthews, D.R. and Skovlund, S.E. (2005) Psychosocial Problems and Barriers to Improved Diabetes Management: Results of the Cross-National Diabetes Attitudes, Wishes and Needs (DAWN) Study. Diabetic Medicine, 22, 1379-1385. https://doi.org/10.1111/j.1464-5491.2005.01644.x
[10]
Abdel Gadir, M., Shebeika, W., Eltom, M., Berne, C. and Wikblad, K. (2009) Health Related Quality of Life and Sense of Coherence in Sudanese Diabetes Subjects with Lower Limb Amputations. Tohoku Journal of Experimental Medicine, 217, 45-50.
[11]
Sadek, A. (2000) Mini International Neuropsychiatric Interview (MINI): The Arabic Translation. In: Psychiatry Update, Vol. 2, Institute of Psychiatry, 23-31.
[12]
American Psychiatric Association (2013) Diagnostic and Statistic Manual of Mental Disorders. 5th Edition, American Psychiatric Association Press, Washington DC.
[13]
Zigmond, A.S. and Snaith, R.P. (1983) The Hospital Anxiety and Depression Scale. Acta Psychiatrica Scandinavica, 67, 361-370. https://doi.org/10.1111/j.1600-0447.1983.tb09716.x
[14]
el-Rufaie, O.E. and Absood, G.H. (1995) Retesting the Validity of the Arabic Version of the Hospital Anxiety and Depression (HAD) Scale in Primary Health Care. Social Psychiatry and Psychiatric Epidemiology, 30, 26-31.
[15]
The WHOQOL Group (1998) Development of the World Health Organization WHOQOL-BREF Quality of Life Assessment. Psychological Medicine, 28, 551-558. https://doi.org/10.1017/S0033291798006667
[16]
Balhara, Y.P.S. (2011) Diabetes and Psychiatric Disorders. Indian Journal of Endocrinology and Metabolism, 15, 274-283. https://doi.org/10.4103/2230-8210.85579
[17]
Mezuk, B., Eaton, W.W., Albrecht, S. and Golden, S.H. (2008) Depression and Type 2 Diabetes over the Lifespan: A Meta-Analysis. Diabetes Care, 31, 2383-2390. https://doi.org/10.2337/dc08-0985
[18]
Campayo, A., de Jonge, P., Roy, J.F., Saz, P., de la Cámara, C., Quintanilla, M.A., et al. (2010) Depressive Disorder and Incident Diabetes Mellitus: The Effect of Characteristics of Depression. The American Journal of Psychiatry, 167, 580-588. https://doi.org/10.1176/appi.ajp.2009.09010038
[19]
Pan, A., Lucas, M., Sun, Q., van Dam, R.M., Franco, O.H., Manson, J.E., et al. (2010) Bidirectional Association between Depression and Type 2 Diabetes Mellitus in Women. Archives of Internal Medicine, 170, 1884-1891. https://doi.org/10.1001/archinternmed.2010.356
[20]
Talbot, F. and Nouwen, A. (2000) A Review of the Relationship between Depression and Diabetes in Adults: Is There a Link? Diabetes Care, 23, 1556-1562. https://doi.org/10.2337/diacare.23.10.1556
[21]
Koopmanschap, N., on behalf of the CODE-2 Advisory Board (2002) Coping with Type 2 Diabetes: The Patient’s Perspective. Diabetologia, 45, S18-S22. https://doi.org/10.1007/s00125-002-0861-2
[22]
Vileikyte, L. (2008) Diabetic Foot Ulcers: A Quality of Life Issue. Diabetes/Metabolism Research and Reviews, 17, 246-249. https://doi.org/10.1002/dmrr.216
[23]
(2002) The Oxford International Diabetes Summit: Implications of the DAWN Study. Practical Diabetes International, 19, 187-192.
[24]
Benbow, S.J., Wallymahmed, M.E. and MacFarlane, I.A. (1998) Diabetic Peripheral Neuropathy and Quality of Life. The Quarterly Journal of Medicine, 91, 733-737. https://doi.org/10.1093/qjmed/91.11.733
