全部 标题 作者
关键词 摘要

OALib Journal期刊
ISSN: 2333-9721
费用:99美元

查看量下载量

相关文章

更多...

Severity of Chronic Obstructive Pulmonary Disease and the Prognosis of Non-Small Cell Lung Cancer Patients

DOI: 10.4236/alc.2016.52002, PP. 13-20

Keywords: Non-Small Cell Lung Cancer, COPD, GOLD, Prognosis

Full-Text   Cite this paper   Add to My Lib

Abstract:

Objectives: We retrospectively analyzed whether the severity of Chronic Obstructive Pulmonary Disease (COPD) affected disease-specific survival in Non-Small-Cell Lung Cancer (NSCLC) patients after surgical resection. Methods: We enrolled 210 NSCLC patients who underwent curative surgery between 2009 and 2011. Classification of COPD severity was based on guidelines of the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Results: A total of 55 patients were diagnosed with COPD. The 5-year disease-specific survival of patients with COPD was not different compared with that of patients without COPD. Among the COPD patients, 40 were classified as GOLD 1, 13 as GOLD 2, and 2 as GOLD 3. Although the number of patients with GOLD 2 - 3 was small, the 5-year disease-specific survival of patients with GOLD 2 - 3 was significantly poorer. We found the prognostic significance of GOLD 2 - 3 in univariate analysis, but failed to find this in multivariate analysis. Conclusions: There is a possibility that the severity of COPD might be useful to predict the prognosis of NSCLC patients.

References

[1]  Izquierdo, J.L., Resano, P., El Hachem, A., Graziani, D., Almonacid, C. and Sanchez, I.M. (2014) Impact of COPD in Patients with Lung Cancer and Advanced Disease Treated with Chemotherapy and/or Tyrosine Kinase Inhibitors. International Journal of Chronic Obstructive Pulmonary Disease, 9, 1053-1058.
http://dx.doi.org/10.2147/COPD.S68766
[2]  de Torres, J.P., Marin, J.M., Casanova, C., Cote, C., Carrizo, S., Cordoba-Lanus, E., Baz-Davila, R., Zulueta, J.J., Aguirre-Jaime, A., Saetta, M., Cosio, M.G. and Celli, B.R. (2011) Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease—Incidence and Predicting Factors. American Journal of Respiratory and Critical Care Medicine, 184, 913-919.
http://dx.doi.org/10.1164/rccm.201103-0430OC
[3]  Wright, C.D., Gaissert, H.A., Grab, J.D., O’Brien, S.M., Peterson, E.D. and Allen, M.S. (2008) Predictors of Prolonged Length of Stay after Lobectomy for Lung Cancer: A Society of Thoracic Surgeons General Thoracic Surgery Database Risk-Adjustment Model. The Annals of Thoracic Surgery, 85, 1857-1865.
http://dx.doi.org/10.1016/j.athoracsur.2008.03.024
[4]  Kozower, B.D., Sheng, S., O’Brien, S.M., Liptay, M.J., Lau, C.L., Jones, D.R., Shahian, D.M. and Wright, C.D. (2010) STS Database Risk Models: Predictors of Mortality and Major Morbidity for Lung Cancer Resection. The Annals of Thoracic Surgery, 90, 875-881.
http://dx.doi.org/10.1016/j.athoracsur.2010.03.115
[5]  Bernard, A., Rivera, C., Pages, P.B., Falcoz, P.E., Vicaut, E. and Dahan, M. (2011) Risk Model of In-Hospital Mortality after Pulmonary Resection for Cancer: A National Database of the French Society of Thoracic and Cardiovascular Surgery (Epithor). The Journal of Thoracic and Cardiovascular Surgery, 141, 449-458.
http://dx.doi.org/10.1016/j.jtcvs.2010.06.044
[6]  Zhai, R., Yu, X., Shafer, A., Wain, J.C. and Christiani, D.C. (2014) The Impact of Coexisting COPD on Survival of Patients with Early-Stage Non-Small Cell Lung Cancer Undergoing Surgical Resection. Chest, 145, 346-353.
http://dx.doi.org/10.1378/chest.13-1176
[7]  Tammemagi, C.M., Neslund-Dudas, C., Simoff, M. and Kvale, P. (2003) Impact of Comorbidity on Lung Cancer Survival. International Journal of Cancer, 103, 792-802.
http://dx.doi.org/10.1002/ijc.10882
[8]  Lopez-Encuentra, A., Astudillo, J., Cerezal, J., Gonzalez-Aragoneses, F., Novoa, N. and Sanchez-Palencia, A. (2005) Prognostic Value of Chronic Obstructive Pulmonary Disease in 2994 Cases of Lung Cancer. European Journal of Cardiothoracic Surgery, 27, 8-13.
http://dx.doi.org/10.1016/j.ejcts.2004.09.010
[9]  Sekine, Y., Behnia, M. and Fujisawa, T. (2002) Impact of COPD on Pulmonary Complications and on Long-Term Survival of Patients Undergoing Surgery for NSCLC. Lung Cancer, 37, 95-101.
http://dx.doi.org/10.1016/S0169-5002(02)00014-4
[10]  Ueda, K., Jinbo, M., Li, T.S., Yagi, T., Suga, K. and Hamano, K. (2006) Computed Tomography-Diagnosed Emphysema, Not Airway Obstruction, Is Associated with the Prognostic Outcome of Early-Stage Lung Cancer. Clinical Cancer Research, 12, 6730-6736.
http://dx.doi.org/10.1158/1078-0432.CCR-06-1196
[11]  Lopez-Encuentra, A., Gomez de la Camara, A., Rami-Porta, R., Duque-Medina, J.L., de Nicolas, J.L. and Sayas, J. (2007) Previoustumour as a Prognostic Factor in Stage I Non-Small Cell Lung Cancer. Thorax, 62, 386-390.
http://dx.doi.org/10.1136/thx.2005.051615
[12]  Lee, S.J., Lee, J., Park, Y.S., Lee, C.H., Lee, S.M., Yim, J.J., Yoo, C.G., Han, S.K. and Kim, Y.W. (2014) Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Non-Small-Cell Lung Cancer. Journal of Thoracic Oncology, 9, 812-817.
http://dx.doi.org/10.1097/JTO.0000000000000158
[13]  Gullon, J.A., Suarez, I., Medina, A., Rubinos, G., Fernandez, R. and Gonzalez, I. (2011) Role of Emphysema and Airway Obstruction in Prognosis of Lung Cancer. Lung Cancer, 71, 182-185.
http://dx.doi.org/10.1016/j.lungcan.2010.05.018
[14]  Gao, Y.H., Guan, W.J., Liu, Q., Wang, H.Q., Zhu, Y.N., Chen, R.C. and Zhang, G.J. (2016) Impact of COPD and Emphysema on Survival of Patients with Lung Cancer: A Meta-Analysis of Observational Studies. Respirology, 21, 269-279.
http://dx.doi.org/10.1111/resp.12661
[15]  Celli, B.R. and MacNee, W. (2004) Standards for the Diagnosis and Treatment of Patients with COPD: A Summary of the ATS/ERS Position Paper. The European Respiratory Journal, 23, 932-946.
http://dx.doi.org/10.1183/09031936.04.00014304
[16]  Pauwels, R.A., Buist, A.S., Calverley, P.M., Jenkins, C.R. and Hurd, S.S. (2001) Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop Summary. American Journal of Respiratory and Critical Care Medicine, 163, 1256-1276.
http://dx.doi.org/10.1164/ajrccm.163.5.2101039
[17]  Couraud, S., Zalcman, G., Milleron, B., Morin, F. and Souquet, P.J. (2012) Lung Cancer in Never Smokers—A Review. European Journal of Cancer, 48, 1299-1311.
http://dx.doi.org/10.1016/j.ejca.2012.03.007
[18]  Govindan, R., Ding, L., Griffith, M., Subramanian, J., Dees, N.D., Kanchi, K.L., Maher, C.A., Fulton, R., Fulton, L., Wallis, J., Chen, K., Walker, J., McDonald, S., Bose, R., Ornitz, D., Xiong, D., You, M., Dooling, D.J., Watson, M., Mardis, E.R. and Wilson, R.K. (2012) Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers. Cell, 150, 1121-1134.
http://dx.doi.org/10.1016/j.cell.2012.08.024
[19]  Nakamura, H. and Saji, H. (2014) Worldwide Trend of Increasing Primary Adenocarcinoma of the Lung. Surgery Today, 44, 1004-1012.
http://dx.doi.org/10.1007/s00595-013-0636-z

Full-Text

Contact Us

service@oalib.com

QQ:3279437679

WhatsApp +8615387084133