Objectives:We retrospectively analyzed whether the severity of
Chronic Obstructive Pulmonary Disease (COPD) affected disease-specific survival in Non-Small-Cell Lung
Cancer (NSCLC) patients after surgical resection. Methods:We enrolled 210NSCLC patients who underwent curative surgery
between 2009 and 2011. Classification of COPD severity was based on guidelines
of the Global Initiative for Chronic Obstructive Lung Disease (GOLD). Results:A total of 55 patients were diagnosed with COPD.The 5-year disease-specificsurvival of patients with COPD was not different
compared with that of patients without COPD. Among the COPD patients, 40 were
classified as GOLD 1, 13 as GOLD 2, and 2 as GOLD 3. Although the number of patients
with GOLD 2-3 was small, the 5-year disease-specificsurvival of patients with GOLD 2-3 was
significantly poorer. We found the prognostic significance of GOLD 2-3 in
univariate analysis, but
failed to find this in multivariate analysis. Conclusions:There is a possibility that the severity of COPD
might be useful to predict the prognosis of NSCLC patients.
References
[1]
Izquierdo, J.L., Resano, P., El Hachem, A., Graziani, D., Almonacid, C. and Sanchez, I.M. (2014) Impact of COPD in Patients with Lung Cancer and Advanced Disease Treated with Chemotherapy and/or Tyrosine Kinase Inhibitors. International Journal of Chronic Obstructive Pulmonary Disease, 9, 1053-1058. http://dx.doi.org/10.2147/COPD.S68766
[2]
de Torres, J.P., Marin, J.M., Casanova, C., Cote, C., Carrizo, S., Cordoba-Lanus, E., Baz-Davila, R., Zulueta, J.J., Aguirre-Jaime, A., Saetta, M., Cosio, M.G. and Celli, B.R. (2011) Lung Cancer in Patients with Chronic Obstructive Pulmonary Disease—Incidence and Predicting Factors. American Journal of Respiratory and Critical Care Medicine, 184, 913-919. http://dx.doi.org/10.1164/rccm.201103-0430OC
[3]
Wright, C.D., Gaissert, H.A., Grab, J.D., O’Brien, S.M., Peterson, E.D. and Allen, M.S. (2008) Predictors of Prolonged Length of Stay after Lobectomy for Lung Cancer: A Society of Thoracic Surgeons General Thoracic Surgery Database Risk-Adjustment Model. The Annals of Thoracic Surgery, 85, 1857-1865.
http://dx.doi.org/10.1016/j.athoracsur.2008.03.024
[4]
Kozower, B.D., Sheng, S., O’Brien, S.M., Liptay, M.J., Lau, C.L., Jones, D.R., Shahian, D.M. and Wright, C.D. (2010) STS Database Risk Models: Predictors of Mortality and Major Morbidity for Lung Cancer Resection. The Annals of Thoracic Surgery, 90, 875-881.
http://dx.doi.org/10.1016/j.athoracsur.2010.03.115
[5]
Bernard, A., Rivera, C., Pages, P.B., Falcoz, P.E., Vicaut, E. and Dahan, M. (2011) Risk Model of In-Hospital Mortality after Pulmonary Resection for Cancer: A National Database of the French Society of Thoracic and Cardiovascular Surgery (Epithor). The Journal of Thoracic and Cardiovascular Surgery, 141, 449-458.
http://dx.doi.org/10.1016/j.jtcvs.2010.06.044
[6]
Zhai, R., Yu, X., Shafer, A., Wain, J.C. and Christiani, D.C. (2014) The Impact of Coexisting COPD on Survival of Patients with Early-Stage Non-Small Cell Lung Cancer Undergoing Surgical Resection. Chest, 145, 346-353. http://dx.doi.org/10.1378/chest.13-1176
[7]
Tammemagi, C.M., Neslund-Dudas, C., Simoff, M. and Kvale, P. (2003) Impact of Comorbidity on Lung Cancer Survival. International Journal of Cancer, 103, 792-802.
http://dx.doi.org/10.1002/ijc.10882
[8]
Lopez-Encuentra, A., Astudillo, J., Cerezal, J., Gonzalez-Aragoneses, F., Novoa, N. and Sanchez-Palencia, A. (2005) Prognostic Value of Chronic Obstructive Pulmonary Disease in 2994 Cases of Lung Cancer. European Journal of Cardiothoracic Surgery, 27, 8-13.
http://dx.doi.org/10.1016/j.ejcts.2004.09.010
[9]
Sekine, Y., Behnia, M. and Fujisawa, T. (2002) Impact of COPD on Pulmonary Complications and on Long-Term Survival of Patients Undergoing Surgery for NSCLC. Lung Cancer, 37, 95-101. http://dx.doi.org/10.1016/S0169-5002(02)00014-4
[10]
Ueda, K., Jinbo, M., Li, T.S., Yagi, T., Suga, K. and Hamano, K. (2006) Computed Tomography-Diagnosed Emphysema, Not Airway Obstruction, Is Associated with the Prognostic Outcome of Early-Stage Lung Cancer. Clinical Cancer Research, 12, 6730-6736.
http://dx.doi.org/10.1158/1078-0432.CCR-06-1196
[11]
Lopez-Encuentra, A., Gomez de la Camara, A., Rami-Porta, R., Duque-Medina, J.L., de Nicolas, J.L. and Sayas, J. (2007) Previoustumour as a Prognostic Factor in Stage I Non-Small Cell Lung Cancer. Thorax, 62, 386-390. http://dx.doi.org/10.1136/thx.2005.051615
[12]
Lee, S.J., Lee, J., Park, Y.S., Lee, C.H., Lee, S.M., Yim, J.J., Yoo, C.G., Han, S.K. and Kim, Y.W. (2014) Impact of Chronic Obstructive Pulmonary Disease on the Mortality of Patients with Non-Small-Cell Lung Cancer. Journal of Thoracic Oncology, 9, 812-817.
http://dx.doi.org/10.1097/JTO.0000000000000158
[13]
Gullon, J.A., Suarez, I., Medina, A., Rubinos, G., Fernandez, R. and Gonzalez, I. (2011) Role of Emphysema and Airway Obstruction in Prognosis of Lung Cancer. Lung Cancer, 71, 182-185. http://dx.doi.org/10.1016/j.lungcan.2010.05.018
[14]
Gao, Y.H., Guan, W.J., Liu, Q., Wang, H.Q., Zhu, Y.N., Chen, R.C. and Zhang, G.J. (2016) Impact of COPD and Emphysema on Survival of Patients with Lung Cancer: A Meta-Analysis of Observational Studies. Respirology, 21, 269-279.
http://dx.doi.org/10.1111/resp.12661
[15]
Celli, B.R. and MacNee, W. (2004) Standards for the Diagnosis and Treatment of Patients with COPD: A Summary of the ATS/ERS Position Paper. The European Respiratory Journal, 23, 932-946. http://dx.doi.org/10.1183/09031936.04.00014304
[16]
Pauwels, R.A., Buist, A.S., Calverley, P.M., Jenkins, C.R. and Hurd, S.S. (2001) Global Strategy for the Diagnosis, Management, and Prevention of Chronic Obstructive Pulmonary Disease. NHLBI/WHO Global Initiative for Chronic Obstructive Lung Disease (GOLD) Workshop Summary. American Journal of Respiratory and Critical Care Medicine, 163, 1256-1276. http://dx.doi.org/10.1164/ajrccm.163.5.2101039
[17]
Couraud, S., Zalcman, G., Milleron, B., Morin, F. and Souquet, P.J. (2012) Lung Cancer in Never Smokers—A Review. European Journal of Cancer, 48, 1299-1311.
http://dx.doi.org/10.1016/j.ejca.2012.03.007
[18]
Govindan, R., Ding, L., Griffith, M., Subramanian, J., Dees, N.D., Kanchi, K.L., Maher, C.A., Fulton, R., Fulton, L., Wallis, J., Chen, K., Walker, J., McDonald, S., Bose, R., Ornitz, D., Xiong, D., You, M., Dooling, D.J., Watson, M., Mardis, E.R. and Wilson, R.K. (2012) Genomic Landscape of Non-Small Cell Lung Cancer in Smokers and Never-Smokers. Cell, 150, 1121-1134. http://dx.doi.org/10.1016/j.cell.2012.08.024
[19]
Nakamura, H. and Saji, H. (2014) Worldwide Trend of Increasing Primary Adenocarcinoma of the Lung. Surgery Today, 44, 1004-1012.
http://dx.doi.org/10.1007/s00595-013-0636-z