Silicone rubber films were modified by the consecutive grafting of 2-(diethylamino)ethyl methacrylate
(DEAEMA) and N-vinylcaprolactam (NVCL) using direct method on two steps with gamma-rays. The effect of absorbed dose and monomer concentration on grafting degree was determined.
The grafted samples were verified by FTIR-ATR spectroscopy and swelling; thermal properties
were analyzed by DSC and TGA. The stimuli-responsive behavior was studied by swelling
and/or DSC. Thermo- and pH-sensitive films of (PP-g-DEAEMA)-g-NVCL presented a pH critical at
3.2 and LCST around 63.5℃.
References
[1]
Deghiedy, N.M.A. (2004) Synthesis and Characterization of Superabsorbent Hydrogels Based on Natural Polymers Using Ionizing Radiations Thesis National Center for Radiation. National Center for Radiation Research and Technology, Al-Azhar University. https://inis.iaea.org/search/search.aspx?orig_q=RN:43081203
[2]
Aramwit, P. (2016) 1-Introduction to Biomaterials for Wound Healing. Wound Healing Biomaterials, Woodhead Publishing, Cambridge, 3-38. http://dx.doi.org/10.1016/B978-1-78242-456-7.00001-5
[3]
Williams, D.F. (1986) Definitions in Biomaterials. Consensus Conference of the European Society for Biomaterials. European Society for Biomaterials, Chester, 3-5 March, 1986, 216.
[4]
Helsen, J.A. and Missirlis, Y. (2010) Biomaterials—A Tantalus Experience. Springer Heidelberg Dordrecht London New York, Berlin.
[5]
Wong, J.Y., Bronzino, J.D. and Peterson, D.R. (2013) Biomaterials—Principles and Practices. 2nd Edition, Vol. 1. Taylor & Francis Group, Boca Raton.
[6]
Bruck, S.D. (1980) Properties of Biomaterials in the Physiological Environment. CRC Press, Boca Raton. http://trove.nla.gov.au/version/10631896
[7]
Kato, K., Uchida, E., Kang, T., Uyama, Y. and Ikada, Y. (2003) Polymer Surface with Graft Chains. Progress in Polymer Science, 28, 209-259. http://dx.doi.org/10.1016/S0079-6700(02)00032-1
[8]
Ahad, I.U., Bartnik, A., Fiedorowicz, H., Kostecki, J., Korczyc, B., Ciach, T. and Brabazon, D. (2014) Surface Modification of Polymers for Biocompatibility via Exposure to Extreme Ultraviolet Radiation. Journal of Biomedical Materials Research Part A, 102, 3298-3310. http://dx.doi.org/10.1002/jbm.a.34958
[9]
Alvarez-Lorenzo, C., Bucio, E., Burillo, G. and Concheiro, A. (2010) Medical Devices Modified at the Surface by Gamma-Ray Grafting for Drug Loading and Delivery. Expert Opinion on Drug Delivery, 7, 173-185. http://dx.doi.org/10.1517/17425240903483174
[10]
Vahdat, A., Bahrami, H., Ansari, N. and Ziaie, F. (2007) Radiation Grafting of Styrene onto Polypropylene Fibers by a 10 MeV Electron Beam. Radiation Physics and Chemistry, 76, 787-793. http://dx.doi.org/10.1016/j.radphyschem.2006.05.009
[11]
Mandal, D.K., Bhunia, H., Bajpai, P.K., Chaudhari, C.V., Dubey, K.A. and Varshney, L. (2016) Radiation-Induced Grafting of Acrylic Acid onto Polypropylene Film and Its Biodegradability. Radiation Physics and Chemistry, 123, 37-45. http://dx.doi.org/10.1016/j.radphyschem.2016.02.011
[12]
Ortega, A., Alarcón, D., Munoz-Munoz, F., Garzón-Fontecha, A. and Burillo, G. (2015) Radiation Grafting of pH-Sensitive Acrylic Acid and 4-Vinyl Pyridine onto Nylon-6 Using One- and Two-Step Methods. Radiation Physics and Chemistry, 109, 6-12. http://dx.doi.org/10.1016/j.radphyschem.2014.12.006
[13]
Chapiro, A. (1964) Radiation Chemistry of Polymers, Basic Mechanisms in the Radiation Chemistry of Aqueous Media. Radiation Research Supplement, 4, 179-191. http://dx.doi.org/10.2307/3583578
[14]
Meléndez-Ortiz, I., Varca, G.H.C., Lugao, A.B. and Bucio, E. (2015) Smart Polymers and Coatings Obtained by Ionizing Radiation: Synthesis and Biomedical Applications. Open Journal of Polymer Chemistry, 5, 17-33. http://dx.doi.org/10.4236/ojpchem.2015.53003
[15]
IAEA (2003) Advances in Radiation Chemistry of Polymers. International Atomic Energy Agency, Vienna. http://www-pub.iaea.org/mtcd/publications/pdf/te_1420_web.pdf
[16]
Ferraz, C.C., Varca, G.H.C., Ruiz, J.C., Lopes, P.S., Mathor, M.B., Lugao, A.B. and Bucio, E. (2014) Radiation-Grafting of Thermo- and pH-Responsive Poly (N-Vinylcaprolactam-Co-Acrylic Acid) onto Silicone Rubber and Polypropylene Films for Biomedical Purposes. Radiation Physics and Chemistry, 97, 298-303. http://dx.doi.org/10.1016/j.radphyschem.2013.12.027
[17]
Contreras-García, A., Burillo, G., Aliev, R. and Bucio, E. (2008) Radiation Grafting of N,N’-Dimethylacrylamide and N-Isopropylacrylamide onto Polypropylene Films by Two-Step Method. Radiation Physics and Chemistry, 77, 936-940. http://dx.doi.org/10.1016/j.radphyschem.2008.02.007
[18]
Klouda, L. (2015) Thermoresponsive Hydrogels in Biomedical Applications a Seven-Year Update. European Journal of Pharmaceutics and Biopharmaceutics, 97, 338-349. http://dx.doi.org/10.1016/j.ejpb.2015.05.017
[19]
Gutowska, A., Bark, J.S., Kwon, I.C., Bae, Y.H., Cha, Y. and Kim, S.W. (1997) Squeezing Hydrogels for Controlled Oral Drug Delivery. Journal of the Controlled Release, 48, 141-148. http://dx.doi.org/10.1016/S0168-3659(97)00041-2
[20]
Lau, A.C.W. and Wu, C. (1999) Thermally Sensitive and Biocompatible Poly (N-Vinylcaprolactam): Synthesis and Characterization of High Molar Mass Linear Chains. Macromolecules, 32, 581-584. http://dx.doi.org/10.1021/ma980850n
[21]
Nakabayashi, K. and Mori, H. (2013) Recent Progress in Controlled Radical Polymerization of N-Vinyl monomers. European Polymer Journal, 49, 2808-2838. http://dx.doi.org/10.1016/j.eurpolymj.2013.07.006
[22]
Valencia-Mora, R.A., Zavala-Lagunes, E. and Bucio, E. (2016) Grafting of Thermo-Sensitive N-Vinylcaprolactam onto Silicone Rubber through the Direct Radiation Method. Radiation Physics and Chemistry, 124, 155-158. http://dx.doi.org/10.1016/j.radphyschem.2015.11.003
[23]
Cheng, S.C., Feng, W., Pashikin, I.I., Yuan, L.H., Deng, H.C. and Zhou, Y. (2002) Radiation Polymerization of Thermo-Sensitive Poly (N-Vinylcaprolactam). Radiation Physics and Chemistry, 63, 517-519. http://dx.doi.org/10.1016/S0969-806X(01)00638-7
[24]
Bütün, V., Billingham, N.C. and Armes, S.P. (1997) Synthesis and Aqueous Solution Properties of Novel Hydrophilic/Hydrophilic Block Copolymers Based on Tertiary Amine Methacrylates and Poly (Ethylene Oxide). Chemical Communications, 7, 671-672. http://dx.doi.org/10.1039/a700772h
[25]
Rogero, S.O., Sousa, J.S., Alário, D., Lopérgolo, L. and Lugao, A.B. (2005) Silicone Crosslinked by Ionizing Radiation as Potential Polymeric Matrix for Drug Delivery. Nuclear Instruments & Methods in Physics Research, 236, 521-525. http://dx.doi.org/10.1016/j.nimb.2005.04.031
