Evaluation of some
biomarkers of inflammation in male Albino Wistar rats following ingestion of
Nigerian Bonny Light Crude Oil (NBLCO) and the effect of antioxidant
supplementation was the focus of this study. Forty-eight adult male Albino
Wistar rats weighing 150 - 180 g were randomly divided 8 per group into: group
I (control) oral gavaged 3 ml/kg of normal saline; group II received 3 ml/kg of
NBLCO; groups III, IV and V received in addition to 3 ml/kg of NBLCO 1 ml/kg
vitamin C, vitamin E and 3 ml/kg of honey bee respectively; group VI received 3
ml/kg of honey. After 28 days of treatment, all animals were anaesthetized with
chloroform and blood collected by cardiac puncture for analysis. Results showed
that NBLCO administration significantly increased erythrocyte sedimentation
rate and C-reactive protein while supplementation with antioxidant
significantly reversed such effects (p < 0.05). NBLCO significantly reduced
platelets and fibrinogen levels compared with the control group (p < 0.05).
Interestingly, the vitamin supplementation significantly reduced platelets and
fibrinogen levels compared to group II (NBLCO) (p < 0.05). Honey
supplementation on the other hand significantly reduced platelets and
fibrinogen compared to group II (NBLCO) (p < 0.05). From the results
obtained it is concluded that ingestion of NBLCO has the potential to induce
development and progression of inflammation but could substantially be
mitigated by supplementation with antioxidant vitamins C, E and honey.
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