Autoimmune extraintestinal manifestations of Helicobacter pylori infection: A bundle of conflicts

It has been well-known that several microorganisms that have an effect on particular areas of the body might additionally have systemic sequelae. In the last ten years, various studies have been performed on the relationship between Helicobacter pylori infection and a variety of extra digestive illnesses including immunological, hematological, neurological disorders and different pathologies. It has been recommended that complicated interactions between bacterial and host genetic factors, as well as environmental factors, play considerable roles in determining different clinical outcomes. Although, there are conflicting and controversy data in some diseases, in the light of literature, it is currently accepted; that the presence or absence of H. pylori infection might influence the chance of developing of many autoimmune diseases. Treatment of H. pylori infection has been reported to be effective in some diseases like Schoenlein-Henoch purpura, ITP, psoriasis and chronic autoimmune urticaria. This review focuses the possible role of H. pylori infections in various autoimmune diseases taking into account the recent literature.