Two types of Korsakoff alcoholism in reference to habenula: A new opinion

Herein it is newly suggested that there are at least two types of Korsakoff alcoholism, one resulting from alcohol intake as regular appetitive habit, while another for relief of psychological stress. It is required the habenula intact to control the intake volume of alcohol, so that it is required the habenula intact for the regular appetitive habit without vomit. Whereas for relief of psychological stress, it is necessary to inhibit the activities of habenula in mediating stress and depression, which would gradually result in the degeneration of limbic input to the habenula. In this regard, it is classified the Korsakoff alcoholism into two types at early stage in reference to habenula.