Non-Steroidal Anti-Inflammatory
Drugs (NSAIDs) are usually suitable candidates for the development of drug
delivery devices. Sol-gel chemistry represents an easy method to obtain porous
silica nanoparticles. Mesoporous silica nanomaterials have been widely used for
drug delivery purposes. In this work we synthesized silica based materials
using two molar alkoxide:water ratios 1:4 and 1:8, incorporating paracetamol to
develop a nano-sized matrix for controlled release purposes. The samples
exhibited different values for surface area, porosity, particle size and distinct
punctual defects. Infrared and UV-visible spectroscopic studies were carried
out to demonstrate the effect of water concentration and the adequate
incorporation of paracetamol molecules. Nitrogen adsorption characterization
was realized and the estimated BET surface values were from 532 to 825 m2/g.
Kinetic analysis of drug release profiles was performed using the hyperbola
model. Transmission electron micrographs showed that all the materials formed
aggregates of small particles with size between 10 - 60 nm. Mesoporous SiO2 materials were proved to be a suitable system for controlled release of
paracetamol.
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