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Procalcitonin—A Useful Biomarker for Pneumonia Associated with Rhodococcus equi?

DOI: 10.4236/mri.2016.52002, PP. 13-19

Keywords: Foal, Horse, Lung, Pneumonia, Procalcitonin, Rhodococcus equi

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Abstract:

Background: Procalcitonin, a precursor protein of the hormone calcitonin, is a sensitive marker for sepsis in human medicine, which is used for diagnosis of bacterial pneumonia in adults and neonates to initiate antibiotic therapy. Objectives: In this study, procalcitonin was evaluated as a potential biomarker for Rhodococcus equi associated pneumonia. Methods: In four foals procalcitonin was measured at four time-points (day 0 before antibiotic therapy, day 1, 3 and 5/6 during therapy) in plasma using an equine specific ELISA. Inclusion criteria for the study were a positive sepsis score, ultrasonographic evidence of pulmonary abscesses in addition >8 cm, a positive microbiology out of tracheobronchial secretion and positive response to antibiotic treatment (azithromycin 10 mg/kg BDW 24q PO and rifampicin 10 mg/kg BDW 12q PO) within a weak including improvement of clinical status and reduction of ultrasonographic score <8 cm. Results: Procalcitonin concentrations remained below the working range of the ELISA (25 - 1000 ng/ml) in all but one sample. Conclusions: Procalcitonin cannot be regarded a useful biomarker in pneumonia associated with Rhodococcus equi.

References

[1]  Russwurm, S., Oberhoffer, M., Zipfel, P.F., et al. (1999) Procalcitonin—A Novel Biochemical Marker for the Mediator-Directed Therapy of Sepsis. Molecular Medicine Today, 5, 286-287.
http://dx.doi.org/10.1016/S1357-4310(99)01505-1
[2]  Holowaychuk, M.K. and Martin, L.G. (2007) Review of Hypocalcemia in Septic Patients. Journal of Veterinary Emergency and Critical Care, 17, 348-358.
http://dx.doi.org/10.1111/j.1476-4431.2007.00246.x
[3]  Müller, B., White, J.C., Nylen, E.S., et al. (2001) Ubiquitous Expression of the Calcitonin-I Gene in Multiple Tissues in Response to Sepsis. The Journal of Clinical Endocrinology & Metabolism, 86, 396-404.
http://dx.doi.org/10.1210/jc.86.1.396
[4]  Preas, H.L., Nylen, E.S., Snider, R.H., et al. (2001) Effects of Anti-Inflammatory Agents on Serum Levels of Calcitonin Precursors during Human Experimental Endotoxemia. The Journal of Infectious Diseases, 184, 373-376.
http://dx.doi.org/10.1086/322031
[5]  Kumar, A., Roberts, D., Wood, K.E., et al. (2006) Duration of Hypotension before Initiation of Effective Antimicrobial Therapy Is the Critical Determinant of Survival in Human Septic Shock. Critical Care Medicine, 34, 1589-1596.
http://dx.doi.org/10.1097/01.CCM.0000217961.75225.E9
[6]  Cohen, N.D. (1994) Causes of and Farm Management Factors Associated with Disease and Death in Foals. Journal of the American Veterinary Medical Association, 204, 1644-1651.
[7]  Pusterla, N., Magdesian, K.G., Mapes, S., et al. (2006) Expression of Molecular Markers in Blood of Neonatal Foals with Sepsis. American Journal of Veterinary Research, 67, 1045-1049.
http://dx.doi.org/10.2460/ajvr.67.6.1045
[8]  Berg, P. and Lindhardt, B.?. (2012) The Role of Procalcitonin in Adult Patients with Community-Acquired Pneumonia—A Systematic Review. Danish Medical Journal, 59, A4357.
[9]  Julián-Jiménez, A., Timón Zapata, J., Laserna Mendieta, E.J., et al. (2014) Diagnostic and Prognostic Power of Biomarkers to Improve the Management of Community Acquired Pneumonia in the Emergency Department. Enfermedades Infecciosas y Microbiología Clínica, 32, 225-235.
http://dx.doi.org/10.1016/j.eimc.2013.04.015
[10]  Pereira, J.M., Teixeira-Pinto, A., Basílio, C., et al. (2013) Can We Predict Pneumococcal Bacteremia in Patients with Severe Community-Acquired Pneumonia? Journal of Critical Care, 28, 970-974.
http://dx.doi.org/10.1016/j.jcrc.2013.04.016
[11]  Niu, W.Y., Wan, Y.G., Li, M.Y., Wu, Z.X., Zhang, L.G. and Wang, J.X. (2013) The Diagnostic Value of Serum Procalcitonin, IL-10 and C-Reactive Protein in Community Acquired Pneumonia and Tuberculosis. European Review for Medical and Pharmacological Sciences, 17, 3329-3333.
[12]  Muscatello, G., Anderson, G.A., Gilkerson, J.R. and Browning, G.F. (2006) Associations between the Ecology of Virulent Rhodococcus equi and the Epidemiology of R. equi Pneumonia on Australian Thoroughbred Farms. Applied and Environmental Microbiology, 72, 6152-6160.
http://dx.doi.org/10.1128/AEM.00495-06
[13]  Venner, M., Reinhold, B., Beyerbach, M. and Feige, K. (2009) Efficacy of Azithromycin in Preventing Pulmonary Abscesses in Foals. The Veterinary Journal, 179, 301-303.
http://dx.doi.org/10.1016/j.tvjl.2007.10.002
[14]  Venner, M., Credner, N., L?mmer, M. and Giguère, S. (2013) Comparison of Tulathromycin, Azithromycin and Azithromycin-Rifampin for the Treatment of Mild Pneumonia Associated with Rhodococcus equi. Veterinary Record, 173, 397.
http://dx.doi.org/10.1136/vr.101867
[15]  Giguère, S., Hernandez, J., Gaskin, J., Miller, C. and Bowman, J.L. (2003) Evaluation of White Blood Cell Concentration, Plasma Fibrinogen Concentration, and an Agar Gel Immunodiffusion Test for Early Identification of Foals with Rhodococcus equi Pneumonia. Journal of the American Veterinary Medical Association, 222, 775-781.
http://dx.doi.org/10.2460/javma.2003.222.775
[16]  Venner, M., Astheimer, K., L?mmer, M. and Giguère, S. (2013) Efficacy of Mass Antimicrobial Treatment of Foals with Subclinical Pulmonary Abscesses Associated with Rhodococcus equi. Journal of Veterinary Internal Medicine, 27, 171-176.
http://dx.doi.org/10.1111/jvim.12030
[17]  Rieger, M., Kochleus, C., Teschner, D., et al. (2014) A New ELISA for the Quantification of Equine Procalcitonin in Plasma as Potential Inflammation Biomarker in Horses. Analytical and Bioanalytical Chemistry, 406, 5507-5512.
http://dx.doi.org/10.1007/s00216-014-7944-z
[18]  Breuer, J. and Schusser, G.F. (2012) Establishing a Sepsis-Score for Adult Equine Patients. Pferdeheilkunde, 28, 421-428.
[19]  Karzai, W., Oberhoffer, M., Meier-Hellmann, A. and Reinhart, K. (1997) Procalcitonin—A New Indicator of the Systemic Response to Severe Infections. Infection, 25, 329-334.
http://dx.doi.org/10.1007/BF01740811
[20]  Müller, B., Becker, K.L., Schachinger, H., Rickenbacher, P.R., Huber, P.R., Zimmerli, W. and Ritz, R. (2000) Calcitonin Precursors Are Reliable Markers of Sepsis in a Medical Intensive Care Unit. Critical Care Medicine, 28, 977-983.
http://dx.doi.org/10.1097/00003246-200004000-00011
[21]  Russwurm, S., Wiederhold, M., Oberhoffer, M., Stonans, I., Zipfel, P.F. and Reinhart, K. (1999) Molecular Aspects and Natural Source of Procalcitonin. Clinical Chemistry and Laboratory Medicine, 37, 789-797.
http://dx.doi.org/10.1515/CCLM.1999.119
[22]  Toribio, R.E., Kohn, C.W., Leone, G.W., Capen, C.C. and Rosol, T.J. (2003) Molecular Cloning and Expression of Equine Calcitonin, Calcitonin Gene-Related Peptide-I, and Calcitonin Gene-Related Peptide-II. Molecular and Cellular Endocrinology, 199, 119-128.
[23]  Toribio, R.E. (2011) Endocrine Dysregulation in Critically Ill Foals and Horses. Veterinary Clinics of North America: Equine Practice, 27, 35-47.
http://dx.doi.org/10.1016/j.cveq.2010.12.011
[24]  Garcia-Lopez, J.M., Provost, P.J., Rush, J.E., Zicker, S.C., Burmaster, H. and Freeman, L.M. (2001) Prevalence and Prognostic Importance of Hypomagnesemia and Hypocalcemia in Horses That Have Colic Surgery. American Journal of Veterinary Research, 62, 7-12.
http://dx.doi.org/10.2460/ajvr.2001.62.7
[25]  Toribio, R.E., Kohn, C.W., Hardy, J. and Rosol, T.J. (2005) Alterations in Serum Parathyroid Hormone and Electrolyte Concentrations and Urinary Excretion of Electrolytes in Horses with Induced Endotoxemia. Journal of Veterinary Internal Medicine, 19, 223-231.
http://dx.doi.org/10.1111/j.1939-1676.2005.tb02686.x
[26]  Hurcombe, S.D.A., Toribio, R.E., Slovis, N.M., Saville, W.J., Mudge, M.C., MacGillivray, K. and Frazer, M.L. (2009) Calcium Regulating Hormones and Serum Calcium and Magnesium Concentrations in Septic and Critically Ill Foals and Their Association with Survival. Journal of Veterinary Internal Medicine, 23, 335-343.
http://dx.doi.org/10.1111/j.1939-1676.2009.0275.x
[27]  Teschner, D., Rieger, M., Koopmann, C. and Gehlen, H. (2015) Procalcitonin bei Pferden mit akuter Kolik. Pferdeheilkunde, 31, 317-377.
[28]  Altunhan, H., Annagür, A., ?rs, R. and Mehmeto?lu, I. (2011) Procalcitonin Measurement at 24 Hours of Age May Be Helpful in the Prompt Diagnosis of Early-Onset Neonatal Sepsis. International Journal of Infectious Diseases, 15, 854-858.
http://dx.doi.org/10.1016/j.ijid.2011.09.007

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